简介:In2010,theBESCollaboration[1]foundaclearenhancementintheK0K0massdistributionintheJ=ψ!ηK0K0decay.SuchanenhancementisusuallyasignatureofanL=0resonancearoundthreshold,whichinthiscasewouldcorrespondstoanh1statewithquantumnumbersIG(JPC)=0??(1+??).Thish1statewaspredictedbytheChiralUnitarytheoryintheKKinteraction.Becauseoftheconversationlaw,thisstatecanonlydecaytoK0K0channel,andcanbestudiedefficientlyintheJ=ψ!ηK0K0decay.
简介:环境污染的加剧,导致过敏反应相应地增加,由此引伸对第2代组胺Ht受体阻断药开发的日趋重视,新药不断上市,其作用强而持久,对中枢和植物神经系统的不良反应甚微,但部分药物对心脏的毒性却日益突出,过量或同时并用肝酶P450抑制剂偶可出现严重的心律失常(尖端扭转型室性心动过速).为此,对其产生心脏毒性原因及合理应用问题进行探讨,以寻求应用时的防范措施.
简介:ObjectivesToinvestigatetheexpressionofhistamineH1receptors(H1R)inthevestibularnucleusofbrainsteminratsandtheroleofH1Rinmotionsickness(MS).MethodsAtotalof24healthySprague-Dawleyratsweredividedrandomlyintofourgroups(n=6each)whichdeterminediftheanimalswouldreceiveinductionofMSordrug(promethazine)treatment:MS(-)/Drug(-);MS(+)/Drug(-);MS(-)/Drug(+at0.25mg);andMS(+)/Drug(+).MSwasinducedbycomplexmotionstimulationandtheconditionedtasteaversionwasusedasabehavioralindicatorofMS.Thevolumeof0.15%sodiumsaccharinsolution(SS)intakewithin45minutesaftermotionstimulationwasmeasured.H1Rinthevestibularnucleuswasexaminedbyimmunofluorescencestaining.TheexpressionofH1Rproteininbrainstemtissueatvestibularnucleuslevelwasdetectedbywesternblot.ResultsThemeanSSintakevolumeintheMS(+)/Drug(-)group(8.8ml)wassignificantlylessthanthatoftheMS(-)/Drug(-)group(15.1ml)(P<0.01).ThemeanSSintakevolumeoftheMS(-)/Drug(+)group(14.8ml)wassimilartothatoftheMS(-)/Drug(-)group.ThemeanSSintakevolume(9.6ml)oftheMS(+)/Drug(+)groupwasmorethanthatoftheMS(+)/Drug(-)group(P<0.01),butlessthanthatoftheMS(-)/Drug(-)grouporMS(-)/Drug(+)group(P<0.01).ImmunofluorescencestainingshowedpositiveexpressionofH1Rinthevestibularnucleusofbrainstemandtheexpressionwasenhancedbymotionstimulation.WesternblotanalysisshowedthatH1Rproteinexpressedinthebrainstemtissueatvestibularnucleuslevelandtheexpressionalsoincreasedsignificantlyaftermotionstimulation.TheMS-inducedincreaseofH1Rwasnotaffectedsignificantlybypromethazine.ConclusionsH1RsexistinthevestibularnucleusinratsandH1Rexpressionisup-regulatedbymotionstimulation,butnotaffectedbypromethazine.ThefindingsindicatethatthehistaminergicsystemisinvolvedinMS.Promethazine,asanH1Rblocker,mayplayitsanti-MSrolebycompetingthebindingsiteon
简介:LinuxbasednetworkedPCsclustersarereplacingboththeVMEnonuniformdirectmemoryaccesssystemsandSMPsharedmemorysystemsusedpreviouslyfortheonlineeventfilteringandreconstrucion.ToallowanoptimaluseofthedistributedresourcesofPCclustersanopensoftwareframeworkispresentlybeingdevelopedbasedonadataflowparadigmforeventprocessing.Thisframeworkallowsforthedistributionofthedataofphysicseventsandassociatedcalibrationdatatomultiplecomputersfrommultipleinputsourcesforprocessingandthesubsequentcollectionoftheprocessedeventsatmultipleoutputs.Thebasisofthesystemistheeventrepository,basicallyafirst-infirst-outeventstorewhichmaybereadandwritteninamannersimilartosequentialfileaccess.Eventsarestoredinandtransferredbetweenrepositoriesassuitablylargesequencestoenablehighthroughput.Multiplereaderscanreadsimultaneouslyfromasinglerepositorytoreceiveeventsequencesandmultiplewriterscaninserteventsequencestoarepository,Hencerepositoriesareusedforeventdistributionandcollection.Tosupportsynchronisationoftheeventfolowtherepositoryimplementsbaaiers.Abarriermustbewrittenbyallthewritersofarepositorybeforeanyreadercanreadthebarrier,Areadermustreadabarrierbeforeitmayreceivedatafrombehindit.Onlyafterallreadershavereadthebarrieristhebarrieremovedfromtherepository.Abarriermayalsohaveattacheddata,Inthiswaycalibrationdatacanbedistributedtoallproessuingunits.Therepositoriesareimplementedasmulti-threadedCORBAobjectsinC++andCORMAisusedforalldatatransfers,JobsetupscriptsarewritteninpythonandinteractivestatusandhistogramdisplayisprovidedbyaJavaprogram.JobsrununderthePBSbatchsystemprovidingshareduseofresourcesforonlinetriggering,offlinemassreporcessinganduseranalysisjobs.
简介:摘要目的探讨H1受体拮抗剂联合抗幽门螺杆菌治疗慢性荨麻疹的临床疗效。方法抽取130例慢性荨麻疹患者,将Hp阳性的100例随机分为观察组与对照组,每组50例,观察组给予西替利嗪片口服1个月+抗Hp三联疗法持续2周;对照组给予西替利嗪片口服1个月;Hp阴性的30例作为参照,给予西替利嗪片口服1个月。比较三组患者的风团数量、大小、持续时间、瘙痒情况、治疗前后IL-4、IgE、TNF-α的血清水平。结果①观察组痊愈率72.0%(36/50),总有效率对照组94.0%(47/50),对照组痊愈率18.0%(9/50),总有效率对照组58.0%(29/50),阴性组痊愈率66.0%(33/50),总有效率对照组90.0%(45/50),观察组与对照组间的差异具有统计学意义(P<0.05);②治疗前后,观察组患者中Hp转阴者的疗效明显好于未转阴者(P<0.05);Hp阳性者的IL-4、IgE、TNF-α的血清水平明显高于阴性者(P<0.05)。结论Hp与慢性荨麻疹有着密切的关系,联合三联疗法能有效降低慢性荨麻疹患者的IL-4、IgE、TNF-α血清水平,加快恢复,值得临床推广。
简介:目的探讨幽门螺杆菌(Hp)与慢性荨麻疹的关系及三联疗法抗Hp治疗在慢性荨麻疹治疗中的作用及相关机制.方法109例经14C-UBT检测Hp阳性的慢性荨麻疹患者随机分为A、B两组.A组55例,予口服西替利嗪片1个月并加抗Hp三联疗法2周;B组54例,仅予西替利嗪片口服1个月;C组为Hp阴性对照组50例,予西替利嗪片口服1个月.观察各组瘙痒、风团数量、风团大小、风团持续时间及联合抗Hp治疗前后IL-4、TNF-α、IgE的血清水平,比较各组的疗效,分析Hp与慢性荨麻疹的关系及抗Hp治疗在慢性荨麻疹治疗中的作用机制.结果单用西替利嗪,Hp阳性组有效率低于Hp阴性,联合三联疗法后能明显提高有效率,且能降低IL-4、TNF-α、IgE的血清水平.结论Hp与慢性荨麻疹的关系密切,联合三联疗法可通过降低IL-4、TNF-α、IgE的血清水平而有助于慢性荨麻疹的治疗.
简介:染色体17q21.31倒置是普通结构的多型性首先在欧洲人口发现了的900-kb。尽管在倒置区域以内的基因流动被假定可观压制,它关于在H1(非转换的顺序)和H2(转换顺序)之间的基因交换的细节仍然是不清楚的这倒置的haplotypes。这里,我们在17q21.31区域以内描述在一些基因安排之间的基因交换的一张精制地图。用1,546单个核苷酸多型性的HapMap阶段II数据,我们成功地由加入邻居的树重建在欧洲样品推出了96H1和24H2haplotypes。而且,我们分别地与相互、非相互的基因交换识别了15和26条候选人道。在怀有相互的交换的所有15个区域,haplotypes由克隆定序重建了没支持这些交换事件,建议这在某些异质接合的个人在二个姐妹染色体之间的交换发信号被分阶段执行错误区域引起。在另一方面,与非相互的基因流动越过26条道中的4个定序的完成的克隆证实这种基因交换被基因变换引起。在摘要,更加作为在一些基因安排之间的转线路被压制了,基因变换可能是为在17q21.31的基因交换的最重要的机制。
简介:ToexplorethemolecularmechanismofchromatinremodelinginvolvedintheregulationoftranscriptionalactivationofspecificgenesbyamyogenicregulatoryfactorMyogenin,weusedNIH3T3fibroblastswithastablyintegratedH1.1-GFPfusionproteintomonitorhistoneH1movementdirectlybyfluorescencerecov-eryafterphotobleaching(FRAP)inlivingcells.TheobservationfromFRAPexperimentswithmyogenintransfectedfibroblastsshowedthattheexchangerateofhistoneH1inchromatinwasobviouslyincreased,indicatingthatforcedexpressionofexogenousMyogenincaninducechromatinremodeling.Thehyper-acetylationofhistonesH3andH4frommyogenintransfectedfibroblastswasdetectedbytriton-acid-urea(TAU)/SDS(2-D)electrophoresisandWesternblotwithspecificantibodiesagainstacetylatedN-terminiofhistonesH3andH4.RT-PCRanalysisindicatedthatthenAChRa-subunitgenewasexpressedinthetrans-fectedfibroblasts.TheseresultssuggestthattheexpressionofexogenousMyogenincaninducechromatinremodelingandactivatethetranscriotionofMvogenin-targetedgeneinnon-musclecells.