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简介：StudiesonthePharmacyofin-vitroCultivatedCalculusbovis(ICCB)；StudiesonSesquiterpenesConstituentsofLigulariapleurocaulis；IsolationandIdentificationofLabdaneDiterpenoidsfromtheRootsofColeusforskohlii；StudyontheApplicationofIndexofCompositeInformationofChromatographicFingerprintsinQualityControlofTraditional；ChineseMedicine

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简介：Tosolvethedatapersistenceprobleminthemanagementsystem,thispaperusedthepopularobject-relationalmappingframeworkHibernatetoachievethepersistencelayerwhichinamedicinesinventorymanagementsystem.ThispaperdescribedtheadvantagesandprinciplesoftheHibernate,andthenshowedthewrittenworkoftheconfigurationfiles,mappingfiles,persistentclasses,etc.Finally,thepapershowedhowtodisplaythespecificdatainformationintheTableViewerbasedontheEclipseRCPframework.Itisobservedthat,operatingtheobjectsintheHibernateframeworkismoreflexibleandefficientthanusingJDBCdirectly.Adinaddition,theapplicationbasedonEclipseRCPframeworkcantakeovermanyexcellentfeaturesofEclipse,andthedeveloperscanimprovetheirefficiencybythesefeatures.

简介：Objective:Todetecttheinhibitionofurogenitalchlamydiatrachomatis(CT)by12traditionalChinesemedicinesinvitro.Methods:TheinhibitionofCTisolatesbythesemedicineswasdetectedbymicro-culturetechniquewithMcCoycellsinvitro.Results:AllthediuretictraditionalChinesemedicinesinhibitedurogenitalCT.Theminimuminhibitoryconcentrations(MICs)rangedfrom0.122mgml^-1to62.5mgml^-1.DiathussuperbusL.,Poriacocos(Shcw.)Woft,Polyporusumbellatus(Pers.)Fries,andArtemisiacapillariesThunbshowedstrongerinhibitionthantheothereighttraditionalChinesemedicines.Thenumbersandsizesofinclusionsbodiesreducedgraduallyanddisappearedfinallywiththeincreaseoftheconcentrations.Conclusion:Allthe12diuretictraditionalChinesemedicinesinhibitedurogenitalCT.

简介：Theauthorsfocusedtheirattentionontheestablishmentofamesenchymalstemcell(MSC)modelforscreeningtraditionalChinesemedicines(TCMs)soastoinvestigatetheeffectsofShuanglongFormula(SLF)components(Ginsenosidesandsalvianolicacids)andingredients(ginsenosideRb1andsalvianolicacidB)oncardiomyocytedifferentiationfromMSCs.TheSLFcomponentswereanalyzedandquantifiedbyHPLC-TOF-MS.CardiomyocytedifferentiationwasinducedbyculturingMSCsintheinductionmediumsupplementedwithSLFingredients,SLFcomponents,5-azacytidine(5-aza),5-aza+SLFingredientsand5-aza+SLFcomponents,respectively,forupto30d,andevulatedbytheexpressionofCardiac-specificmyosinheavychain(MHC)andtroponinI(TnI)viaimmunofluoresentstaining.Slowgrowthrateandchangedmorphologywereobservedduringcardiomyocytedifferentiation.After20dofinduction,differentiatingMSCswerepositiveforMHCandTnIstaining.TheeffectsofSLFcomponentswerebetterthanthoseofSLFingredients.Takentogether,SLFcaninducethedifferentiationofMSCsintocardiomyogeniccellsinvitro,andMSCscanbeusedasapowerfultoolforscreeningTCMs.

简介：EnhancingSchwanncellproliferationmaybebeneficialforperipheralnerverepairandnerveregeneration.AtraditionalherbalformulacomposedofFuling(poriacocos),Baizhu(Atractylodesmacrocephala),andDanggui(Angelicasinensis)(FBD)improvesneuronalsurvivalandgrowth,andFBDmaypromotethesecretionofbrain-derivedneurotrophicfactor.However,themechanismunderlyingSchwanncellproliferationremainsunclear.WetestedwhetherFBDenhancedtheproliferationofhumanSchwanncells.FBD(20μg/mL)increasedSchwanncellviabilityandsurvival,andincreasedthenumberofcellsatG2/MandSphases.FBDalsoincreasednervegrowthfactorandbrain-derivedneurotrophicfactorexpressioninSchwanncells,withmaximumefficacyat20μg/mL.

简介：Subjective:Toobservethetherapeuticeffectofacupunctureintreatmentofacuteperipheralfacialparalysis.Methods:Atotalof80casesoffacialpalsywererandomlydividedintoacupuncturegroup(n=50)andWesternmedicine(control)group(n=30).Inacupuncturegroup,Cuanzhu(BL2),Sibai(ST2),Yangbai(GB14),etc.werepunctured,combinedwithTDPradiation,cuppingoradministrationofChinesemedicinalherbsaccordingtotheconcretesituations.Acupuncturetreatmentwasgivenoncedaily,with6daysbeingatherapeuticcourse,continuouslyfor4courses.Incontrolgroup,patientsweretreatedwithintravenousinjectionof"energymixture",dexamethasone,compoundDansheninjectio,etc..Results:Aftertreatment,inacupuncturegroup,ofthe50cases,48werecuredand2hadimprovement,withtheeffectiveratebeing100%;amongthem,12caseswerecuredin7days,23curedin8～14days,10curedin15～21daysand3curedin22～28days.Incontrolgroup,ofthe30cases,19werecured,8hadimprovementand3hadnoapparentchanges,withtheeffectiveratebeing90%.Ofthe19curedcases,5werecuredwithin8～14days,10curedin15-21daysand4curedin22～28days.Conclusion:Intreatmentofacuteperipheryfacialpalsy,acupunctureisobviouslysuperiortoWesternmedicinesinthetherapeuticeffectandcureduration.

简介：2015年10月21日,中国科学技术信息研究所发布,ChineseHerbalMedicines再次入选中国科技核心期刊(中国科技论文统计源期刊)。CHM自2013年起连续3年入选中国科技核心期刊,2014年核心影响因子0.541,核心总被引频次121,基金论文比0.46。

简介：ItrecentlybecomesanimportantandurgentmissionformodernscientificresearchtoidentifyandexplainthetheoryoftraditionalChinesemedicine(TCM),whichhasbeenutilizedinChinaformorethanfourmillennia.SincefewworkshavebeencontributedtounderstandingtheTCMtheory,themechanismofactionsofdrugswithcold/hotpropertiesremainsunclear.Inthepresentstudy,sixkindsoftypicalherbswithcoldorhotpropertieswereorallyadministeredintomice,andserumandliversampleswereanalyzedusinganuntargetednuclearmagneticresonance(NMR)basedmetabolomicsapproachcoupledwithsimilarityanalysis.Thisapproachwasperformedtoidentifyandquantifychangesinmetabolicpathwaystoelucidatedrugactionsonthetreatedmice.Ourresultsshowedthatthosedrugswithsamepropertyexertedsimilareffectsonthemetabolicalterationsinmouseserumandliversamples,whiledrugswithdifferentpropertyshoweddifferenteffects.Theeffectsofherbalmedicineswithcold/hotpropertieswereexertedbyregulatingthepathwayslinkedtoglycometabolism,lipidmetabolism,aminoacidsmetabolismandothermetabolicpathways.Theresultselucidatedthedifferencesandsimilaritiesofdrugswithcold/hotproperties,providingusefulinformationontheexplanationofmedicinalpropertiesoftheseTCMs.

简介：Thepresentworkshowsdrug-carrierinteractions,releasebehaviorsandcellresponsesofhydroxyapatite(HA)containingsalvianolicacidB(SalB),astragaluspolysaccharide(APS),andnaringin.X-raydiffraction(XRD)showedthatthecrystallinityandcrystalsizeofHAdecreasedsignificantlywhenSalBwasadded(p<0.05).Transmissionelectronmicroscope(TEM)confirmedthatthenano-acicularcrystalsofHAcontainingSalBwerethemostfineamongallspecimens.ItwasconjecturedthatSalBpreferentiallyadsorbedonthepositivelychargedsurfaceofHAcrystalstoinhibittheirgrowth.InvitroreleaseofHAcontainingChinesemedicinesfollowedthefirst-orderequation.Thedrug-carrieraffinitybetweenHAandSalBmighthaveprolongedthereleaseofSalB.TheproliferationanddifferentiationofosteoblastswerepromotedbyChinesemedicinescontainingHAinthetimeanddosagedependentmanner.Theosteoblastsdisplayedapolygonalmorphologywithcell-celljunctionsinallcases.ItissuggestedthatthecontainedChinesemedicineswouldpromotetheactivitiesoftheosteoblasts.

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简介：Acompetitiveenzyme-linkedimmunosorbentassay(ELISA)wasdevelopedtodetermineruscogenin(RUS)byusingthemonoclonalantibody(McAb).ThemonoclonalantibodyagainstRUS,secretedfromtheestablishedhybridomacelllines,wasidentifiedasbeingoftheIgG1isotype.TheMcAbexhibitedhighspecificitytoRUS,showingaveryslightcrossreactivitywithdiosgenin(15.7%),andnocross-reactivitytosarsasapogenin,diammoniumglycyrrhizinate,oleanolicacidandnotoginsenosideR1.TheestablishedELISA,atanIC50valueof157.55ng.mL-1andadetectionlimit(IC20)of20.57ng.mL-1,wascomparedwithHPLCanalyses,andagoodcorrelationbetweenELISAandHPLC-ELSDanalysesofRUSintheextractofRadixOphiopogoniswasobtained.TheexperimentaldataindicatedthattheELISAmethodexhibitsmoreadvantagesoverHPLC-ELSD,suchaslowdetectionlimit,highspecificity,lowbackground,andnorequirementforsamplepre-treatment,andismoresuitableforthedeterminationofnaturalcomponentsinChinesetraditionalmedicinesandinbiologicalsamplesforpharmacokineticstudies.

简介：AccordingtothetheoryoftraditionalChinesemedicine(TCM),Qi(vitalenergy)isregardedasadrivingforceofbiologicalactivitiesinhumanbody,includingbothnutrientsubstancesandorganfunctions.Qi-invigoratingTCMsarewidelyusedtotreatvarioussymptomsanddisorders,suchasfatigue,obesity,immunosuppression,intestinalfloraimbalance,andgastrointestinaldiseases,inwhichQiisconsideredtobereducedordepleted.Interestingly,abundantclinicalevidencessuggestthatthesedisordersareassociatedwiththealternationofintestinalflora,whichdirectlyaffectsdiseasestatus.HereinwereviewtheinteractionbetweengutmicrobiotaandQi-invigoratingTCMsunderhealthyanddiseaseconditionsanddiscussthemechanismsofactionandapplicationsofQi-invigoratingTCMsinenhancinghealthstatusthroughmicrobialalternation.AbetterunderstandingoftheroleofQi-invigoratingTCMsinmodulatingmicrobialcompositionandtheassociationbetweenintestinalmicrobiotaanddiseaseswouldhelprevealtheclinicalconsequencesofmicrobiotaalterationandexploreopportunitiestoharnessthissymbioticrelationshiptoimprovepublichealth.

简介：AbstractBackground:Soil-transmitted helminthiases (STH) are part of the group of neglected tropical diseases traditionally treated with preventive chemotherapy interventions. In recent years, drug donations have been essential to expanding preventive chemotherapy and achieving progressive control of morbidity from STH. This study aims to evaluate the need for anthelminthic medicines during 2020–2030.Methods:To estimate the need for anthelminthic medicines, we considered three different scenarios: (1) the control programmes continues to expand coverage and maintains the frequency of drug administration established at baseline; (2) the programmes continues to expand coverage but adapts the frequency of drug administration when the STH prevalence is reduced and (3) the STH programme becomes self-sustainable in some endemic countries.Results:We estimate that the number of anthelmintic medicines needed to treat school-aged children will increase by 40% by 2025 and by 52% by 2030 if countries do not change the frequency of preventive chemotherapy (scenario 1); that the number of tablets needed will reduce by 32.4% by 2025 and by 49.1% in 2030 if endemic countries reduce the frequency of preventive chemotherapy (scenario 2); and drug donations could be reduced by 54.4% by 2025 and 74.4% by 2030 if some endemic countries could become independent in drug procurement (scenario 3).Conclusions:The number of anthelmintic medicines needed to achieve elimination of morbidity due to STH in school-aged children will decline during 2020–2030. The decline will be substantial if a number of "upper-middle income" countries in which STH are endemic procure, as expected, anthelminthic medicines independently.