简介：全身的豺狼座erythematosus(SLE)的一个特点是由汽车反应的B房间的各种各样的自身抗体的一致生产。Interferon-α；(IFN-α；)发信号高度在SLEB房间被激活并且由B房间在抗体反应起一个重要作用。以前的研究证明了CD180否定的B房间，戏剧性地在SLE病人被增加，为自身抗体的生产负责。然而，在CD180和IFN-α之间的协会；未知的发信号的遗体。在现在的学习，我们在调整IFN-α的激活上探索了CD180的效果；在B房间发信号。我们发现CD180否定的B房间的数字在MRL/Mp-Fas(lpr/lpr)被增加豺狼座容易的老鼠与野类型的老鼠相比。Phenotypic分析证明CD180否定的B房间包括了CD138+plasmablast/plasma房间和GL-7+幼芽的中心(GC)B房间。尤其是，CD180的结扎显著地禁止了IFN-α；信号变换器的导致的phosphorylation和抄写2的使活跃之物(STAT-2)和以在vitro的一种Lyn-PI3K-BTK-dependent方式的刺激IFN的基因(ISG)的表示。而且，CD180的结扎能也禁止IFN-α；在在vivo的B房间的导致的ISG表示。而且，像使用费的受体7并且像使用费的受体9发信号小径能显著地downregulateCD180表示并且调制在IFN-α的激活上发信号的CD180的禁止的效果；发信号。一起，我们的结果加亮在CD180否定的B房间的增加的比例和IFN-α的激活之间的靠近的协会；在SLE发信号。我们的数据提供分子的卓见进IFN-α的机制；在为SLE处理的SLEB房间和一条潜在的治疗学的途径的发信号的激活。

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简介：为了在压缩机的流动地上探索机翼探查试管和它的款项位置的效果，串联，并且发现机制怎么机翼探查影响压缩机串联的空气动力学的特征，这份报纸在一样的压缩机串联上执行了数字、试验性的工作。实验主要集中了于低马赫数字的案例(妈=0.1)，并且有不同马赫数字的案例(0.1，0.3，0.7)并且不同发生角度(-5,0，5)被数字方法调查。没有机翼探查试管的案例作为基线，和另外的三个案例被引用，机翼探查试管在不同chordwise位置安装了(30%，50%，70%弦长度)被学习。机翼探查试管的直径是3mm，它根据几何类似原则作为某特别机翼探查的300%扩大被设置。结果证明机翼探查试管根本在串联的流动能力上有否定影响调查点。分离和在压力方面上由机翼探查试管导致了的大规模streamwise旋涡在高马赫数字引起大多数损失。在压力方面表面的附近的流动领域上的机翼探查试管的影响是在低马赫数字的本地分离。机翼探查试管也有一清楚地在漏流动上完成。它减少漏流动的集体流动并且削弱漏旋涡的紧张，但是扩大影响区域。试管在chordwise位置通常是的一半被安装的盒子的全部的压力损失特别在高马赫数字比另外的盒子降低，它能甚至减少损失与基本盒子相比。

简介：Inthispaper,wedemonstrateaschemeforcompensatingdistortedopticalvortexbeamscarryingorbitalangularmomentum.ByinputtingtheintensityprofileintotheGerchberg–Saxtonalgorithm[Optik35,237(1972)],thepre-compensationphasemaskcanbeacquired.Noadditionalprobebeamsareintroduced,andallthecomputingisaimingatthetransmittedvortexbeams.Thedistortedvortexbeamsareinvestigatedexperimentallybeforeandafterpre-compensation,showingfavorablecompensationperformance.Thisschemewillfindapplicationsintheareasofrotationdetection,opticalcommunications,andsoon.

简介：AgreatamountoffoodbornepathogenswereGram-positive(G?)bacteria,athreattopublichealth.Inthisstudy,consideringthebindingabilityofnisintowardsG-bacteriaandthestablefluorescentabilityofEGFPprotein,afluorescentnisin–EGFPproteinprobewasconstructedbyageneengineeringmethod.NisinandEGFPwereusedasthereceptorandfluorophore,respectively,todetectG?bacteria.ThenisinandegfpgenewereamplifiedseparatelyaccordingtothesequencepublishedinGenBankusinguniqueprimers.ThetwogeneswereclonedintoapET-28b(?)vectorresultinginapET-28b(?)–nisin–egfpvector.ThevectorwastransferredintoEscherichiacoli(E.coli)BL21(DE3)forexpression.Theexpressedproteinwasextracted,purifiedbyaNi–NTAcolumn,andthentestedbytheSDS-PAGEmethodtoconfirmitsmolecularweight.Listeriamonocytogenes(L.monocytogenes),Staphylococcusaureus(S.aureus),andMicrococcusluteus(M.luteus)wereusedastherepresentationsofG?bacteria.E.coliO157,representingthegram-negative(G-)bacteria,wasusedasanegativecontrol.Thebindingspecificityoftherecombinantproteinwasperformedontwotypesofbacteriaandthendetectedthroughfluorescentmicroscopy.Theresultsindicatedthatthenisin–EGFPprobecoulddetectG?bacteriaat108CFU/mL.

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简介：Piezoelectricsuperlatticeisapotentialcomponentfornanoelectromechanicalsystems.Duetothestrongnonlocaleffectsuchasflexoelectriceffectatinterfaces,classicalpiezoelectrictheoryisunabletoaccuratelydescribetheelectromechanicalresponseofpiezoelectricsuperlatticeatnanoscalescale.BasedonthepreviousnonlocalthermodynamicstheorywithflexoelectriceffectLiuetal.(2016),thesizedependentelectromechanicalpropertiesofpiezoelectricsuperlatticesmadeofBaTiO_3(BTO)andPbTiO_3(PTO)layersareinvestigatedsystematicallyinthepresentwork.GiantstraingradientisfoundneartheinterfacebetweenBTOandPTOlayers,whichleadstothesignificantenhancementofpolarizationinthesuperlatticeduetotheflexoelectriceffect.ForthepiezoelectricBTO–PTOsuperlatticeswithdifferentunitcellsizes,thethicknessofinterfacewithnontrivialstraingradientisalmostconstant.Theinfluenceofstraingradientattheinterfacebecomessignificantwhenthesizeofsuperlatticedecreases.Asaresult,astrongsizedependenceofelectromechanicalpropertiesispredictedforthepiezoelectricBTO–PTOsuperlattices.Inparticular,forthesuperlatticeswithaspecificthicknessratioofBTOandPTOlayers,thepiezoelectricresponsecanbeseveraltimeslargerthanthatofbulkstructure.Thepresentworkdemonstratesapracticalwaytodesignthepiezoelectricsuperlatticeswithhighpiezoelectriccoefficientbyusingthenonlocaleffectatnanoscale.

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简介：Nanostructuredironoxyhydroxide（FeOOH）thinfilmshavebeensynthesizedusinganelectrodepositionmethodonanickelfoam（NF）substrateandeffectofairannealingtemperatureonthecatalyticperformanceisstudied.Theas-depositedandannealedthinfilmswerecharacterizedbyX-raydiffraction（XRD）,X-rayphotoelectronspectroscopy（XPS）,fieldemissionscanningelectronmicroscopy（FE-SEM）andlinearsweepvoltammetry（LSV）todeterminetheirstructural,morphological,compositionalandelectrochemicalproperties,respectively.Theas-depositednanostructuredamorphousFeOOHthinfilmisconvertedintoapolycrystallineFe2O3withhematitecrystalstructureatahightemperature.TheFeOOHthinfilmactsasanefficientelectrocatalystfortheoxygenevolutionreaction（OER）inanalkaline1MKOHelectrolyte.Thefilmannealedat200°Cshowshighcatalyticactivitywithanonsetoverpotentialof240mVwithasmallerTafelslopeof48mV/dec.Additionally,itneedsanoverpotentialof290mVtothedrivethecurrentdensityof10mA/cm2andshowsgoodstabilityinthe1MKOHelectrolytesolution.

简介：在任何地震危险学习的第一步是seismogenic来源和为每来源的大小频率关系的评价的定义。有迄今为止，为来源建模和许多研究人员的标准方法论都没研究这个话题。这研究是定义的一个努力线性并且区域为北伊朗的地震来源。线性或当区域来源基于空间分发被开发时，差错来源基于构造特征和典型地震被开发对中等地震小。当时间无关的频率大小关系基于泊松过程为区域来源被建议时，时间依赖者复发关系用更新途径为差错来源被形成。GIS功能在这研究被使用介绍并且合并空间时间并且在描出的geostatistical索引区域地震来源。建议方法论被用来在德黑兰附近由400方形的公里为大约500的一个区域为地震来源建模。以前的研究和报告被学习编尽可能完全的一个地震/差错目录。所有事件被转变到一致大小规模；副本事件和依赖震动被移开。编的目录的完全性和时间分发被考虑。与定义复发关系一起的建议区域和线性地震来源能被用来开发时间依赖者北伊朗的概率的地震危险分析。

简介：Wereporttheinvestigationontheperformanceofanamplificationassisteddifferencefrequencygeneration(AA-DFG)systemdrivenbypulsedpumpandcontinuous-waveprimarysignallasers.AmonolithictandemlithiumniobatesuperlatticewasemployedasthenonlinearcrystalwithauniformgratingsectionfortheDFGprocess,followedbyachirpsectionfortheopticalparametricamplificationprocess.Theimpactsofpumppulseshape,primarysignalpower,inputbeamdiameter,andcrystalstructureonthepump-to-idlerconversionefficiencyoftheAA-DFGsystemwerecomprehensivelystudiedbynumericallysolvingthecoupledwaveequations.Itisconcludedthatsquarepumppulseandhighprimarysignalpowerarebeneficialtohighpump-to-idlerconversionefficiency.Inaddition,tighterinputbeamfocusandsmallerDFGlengthproportioncouldredeemthereductioninconversionefficiencyresultingfromwideracceptancebandwidthsfortheinputlasers.Webelievethatsuchsystemscombiningthemeritsofhighstabilityinheritedfromcavity-freeconfigurationandhighefficiencyattributedfromthecascadednonlinearconversionshouldbeofgreatinteresttoawidecommunity,especiallywhenthepulseshapingtechniqueisincorporated.

简介：在我们的当前的工作，在有起核心作用的代理人的isotactic聚丙烯(iPP)的水晶的生长上的shear温度的效果被调查借助于在situ二维的宽角度的X光检查衍射(2D-WAXD)。在低砍温度，面向的先锋是的形成的砍导致难由于分子的链的弱活动性放松回到随机的卷的状态。因此，很多的面向的晶体被砍导致导致面向的先锋，当水晶极大地被压抑时。作为shear温度增加，面向的水晶逐渐地与水晶的减少一起增加。这被推出水晶的内容在增加到的shear温度(最大值)在静止结晶化发现的价值在结晶化动力学上的流动的加速的效果哪个完全被擦掉几乎与那一样。我们的工作在结构和iPP的性质操作在调整水晶并且这样表明它的意义。

简介：在这份报纸，我们考虑充分分离的本地不连续的Galerkin方法，在第三命令前进的明确的Runge-Kutta时间被联合的地方。为一个维的时间依赖者有边界层的不可思议地使不安的问题，我们将证明结果的计划具有在本地稳定性的好行为不仅，而且有双optimal本地人错误估计。它是说，集中率在空间和时间是最佳的，并且截止子域的宽度也是将近最佳的，如果在各中间的舞台的边界条件以一个合适的方法被给。数字实验也被给。

简介：BasedontheTaylorseriesmethodandLi’sspatialdifferentialmethod,ahigh-orderhybridTaylor–Lischemeisproposed.Theresultsofalinearadvectionequationindicatethat,usingtheinitialvaluesofthesquare-wavetype,aresultwiththirdorderaccuracyoccurs.However,usinginitialvaluesassociatedwiththeGaussianfunctiontype,aresultwithveryhighprecisionappears.Thestudydemonstratesthat,whentheorderofthetimeintegralismorethanthree,thecorrespondingoptimalspatialdifferenceordercouldbehigherthansix.Theresultsindicatethatthereasonforwhythereisnoimprovementrelatedtoanorderofspatialdifferenceabovesixistheuseofatimeintegralschemethatisnothighenough.TheauthoralsoproposesarecursivedifferentialmethodtoimprovetheTaylor–Lischeme’scomputationspeed.Amorerapidandhighprecisionprogramthandirectcomputationofthehigh-orderspacedifferentialitemisemployed,andthecomputationspeedisdramaticallyboosted.Basedonamultiple-precisionlibrary,theultrahigh-orderTaylor–LischemecanbeusedtosolvetheadvectionequationandBurgers’equation.

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简介：Non-smallcelllungcancer(NSCLC)ranksastheleadingcauseofcancer-relateddeathintheworld.Brainmetastasis(BM)isacommoncomplicationofNSCLC,with25%–40%ofpatientsdevelopingBMduringthecourseofthedisease.Asignificantstrategyoflocaldiseasecontrolinthecentralnervoussystemisradiationtherapy.Withthedevelopmentofprecisionmedicine,theconceptoftreatinglungcancerBMhasgraduallychanged.Inthiscase,weperformedasurgicalproceduretoobtainenoughtumortissueforthedetectionofthetargetgeneandotherrelatedexperimentsafterthepatientwasinformed.Finally,wefoundthatthepatienthadbothhepatocytegrowthfactorreceptor(MET)geneamplificationandkinesinlightchain1-anaplasticlymphomakinasefusion(KLC1-ALK)throughnext-generationsequencingandshowedsensitivitytothetargetedtherapyofcrizotinib.Thepatientexhibitedgoodresponse.Ourcasewassuccessfulandunderwenttargetedtherapywiththeguidanceofprecisediagnosis.

简介：Temperature-dependentphotoluminescencecharacteristicsoforganic-inorganichalideperovskiteCH3NH3PbI3-xClxfilmspreparedusingatwo-stepmethodonZnO/FTOsubstrateswereinvestigated.Surfacemorphologyandabsorptioncharacteristicsofthefilmswerealsostudied.Scanningelectronmicroscopyrevealedlargecrystalsandsubstratecoverage.Theorthorhombic-to-tetragonalphasetransitiontemperaturewas140K.Thefilms’excitonbindingenergywas77.6±10.9meVandtheenergyofopticalphononswas38.8±2.5meV.TheseresultssuggestthatperovskiteCH3NH3PbI3-xClxfilmshaveexcellentoptoelectroniccharacteristicswhichfurthersuggeststheirpotentialusageinperovskitebasedoptoelectronicdevices.