简介：【摘要】：随着城市建设的高速发展、城市人口大量增多、气候条件不断恶化，城市热岛效应带来的影响日益突出。采用热红外影像反演地表温度成为一种高效获取地表温度数据的有效方法。本文利用TM影像以辐射传输方程法和单窗算法分别对青岛西海岸经济新区的陆面温度进行反演，对两种方法得到的温度数据进行横向对比以检验两种反演方法的优劣性，同时对热岛效应区域变化情况进行纵向对比以总结城市热岛效应变化规律。

简介：摘要：社会发展至今，人们的生活质量在不断提高，生活方式也多种多样，但是人一生中有三分之一的时间被草草对待，那就是属于睡眠的时间。睡眠对于人的健康、工作及生活状态都至关重要。

简介：摘要：采用共沉淀法制备了具有Yb3+/Tm3+稀土离子掺杂的YOF纳米前驱体材料，并对其吸光度、红外光谱及荧光性质进行分析。结果表明，共沉淀法可合成多壳层纳米前驱体；其在紫外光区具有较高的吸光度；红外光谱表明其在1081 cm-1处有明显的二氧化硅特征吸收峰；纳米前驱体颗粒的荧光发射能力随着壳层增加逐渐降低，双层包覆时红绿比可低至100左右。

简介：摘要:MT2000型2kW短波广播发射机是目前我台主力军,也是支撑我国广播事业的重要设备之一。这种短波发射机具有抽屉式部件组成、占地面积小、维护检修方便，信号较为稳定、故障指示准确，工作效率突出等优点。但是此款短波发射机功放350w电路板上的F4480晶体管故障率相对高。

简介：摘要 目的 观察在造血干细胞移植术（HSCT）患者术前应用3M爱护佳TM皮肤及手清洗消毒液实施全身皮肤消毒的效果。方法 以我科2019年1月1日至2020年07月30日入住层流病房的患者50例为对照组，入住层流病房当天用1:2000醋酸氯己定溶液浸浴30min；2020年8月1日至2021年8月30日入住层流病房的患者50例为研究组，入住层流病房当天用3M爱护佳TM消毒液擦拭全身，淋浴即可。比较两组细菌培养阳性率和患者药浴相关不良反应发生情况。结果 研究组各部位细菌培养阳性结果、不良反应发生率均低于对照组（P＜0.05）。结论 3M爱护佳TM免洗手消毒液淋浴法用于HSCT病人术前全身皮肤消毒效果确切，安全性高，耐受性好，不良反应较低，提高了患者的舒适度。

简介：摘 要：随着我国经济水平的不断提升，城市化进程也随之加快，为了能够协调好人与自然之间的关系，在满足人们居住、工作用房的同时降低土地资源浪费，各类高层建筑崛地而起。而这些高层建筑最令人担心的问题就是质量，因此也就需要相关施工人员能够注重各类相关技术的使用，以此不断提升高层建筑的稳定性、安全性。在众多技术中，铝模板施工工艺的应用最为广泛，不仅使得形状、尺寸的调整更加便利，同时也大大提升了整体施工质量。基于此，本文针对铝膜板在高层建筑施工中的应用展开研究，希望可以为相关施工人员更好地开展高层建筑施工工作提供一定参考。

简介：摘要目的探讨中国东北地区汉族人群patatin样磷脂酶域3（PNPLA3）rs738409及跨膜蛋白6超家族2（TM6SF2）rs58542926基因多态性与原发性肝癌发病的相关性。方法采用病例-对照研究，纳入521例原发性肝癌患者作为病例组，164名健康人作为对照组。病例组根据病因学分为有及无肝硬化组。采用聚合酶链反应（PCR）方法分别检测PNPLA3 rs738409及TM6SF2 rs58542926两个位点的基因多态性。对计量资料用t检验、方差分析或U检验，对计数资料用χ2检验或Fisher确切概率法。结果病例组与对照组相比，PNPLA3 rs738409 G等位基因频率分布存在明显差异（OR = 1.583，P = 0.001）；进一步分组后显示，除在丙型病毒性肝炎相关性肝癌组中与对照组差异无统计学意义外（P = 0.161），在其他分组中均存在明显差异（P值均< 0.05）。与对照组相比，病例组TM6SF2 rs58542926 T等位基因频率明显高于对照组（OR = 1.759，P = 0.048）。分组后仅合并肝硬化肝癌组CT/TT基因型频率及酒精性相关性肝癌组T等位基因频率与对照组的差异有统计学意义（P值分别为0.045，0.032）。将病例组按照是否携带PNPLA3 rs738409 G等位基因分成CG/GG与CC组；按照是否携带TM6SF2 rs58542926 T等位基因分成CT/TT与CC组，结果显示，CG/GG与CC组及CT/TT与CC组肝脏酶学指标、白蛋白（Alb）、总胆红素（TBil）、甲胎蛋白（AFP）及空腹血糖水平的差异均无统计学意义。将病例组伴有肝硬化的患者根据Child-Pugh评分分为≥7分组与< 7分组，结果显示，PNPLA3 rs738409 CG/GG型与CC型患者的Child-Pugh评分差异及TM6SF2 rs58542926 CT/TT型与CC型患者的Child-Pugh评分差异均无统计学意义（P值均> 0.05)。结论PNPLA3 rs738409及TM6SF2 rs58542926基因多态性在中国东北地区汉族人群中与原发性肝癌的发生存在相关性。PNPLA3 rs738409及TM6SF2 rs58542926基因多态性在原发性肝癌中对肝脏酶学、Alb、TBil、AFP及空腹血糖等指标没有影响。

简介：AbstractAfrican swine fever virus (ASFV) is the causative agent of African swine fever, a highly fatal hemorrhagic disease of pigs, which has resulted in great economic losses to the global pork industry, especially in Asia. ASFV particles are comprised of multiple layers encompassing the genomic DNA. Though the capsid structure has been determined, very little is known about the structure of the core shell. The precursor polyprotein pp62 is the structural component of the core shell that gives rise to the p35 and p15 proteins. Herein, we describe the crystal structure of p15 at a resolution of 2.2 Å. The structure of p15 exhibits as a trimeric conformation that is mainly mediated by intermolecular disulfide bonds and supported by multiple hydrogen bond interactions. The button conformation on the surface of adjacent molecules may also play a role in trimeric formation of the ASFV p15. The center of the p15 trimer exhibits opposite electrostatic characteristics on each side. These findings benefit our understanding of ASFV core shell assembly and will aid in the design of antiviral drugs and vaccines.

简介：AbstractBackground:Hepatitis B core-related antigen (HBcrAg) is a promising disease-monitoring marker for chronic hepatitis B (CHB). We investigated correlations between HBcrAg with antiviral efficacy and virological and histological variables.Methods:One hundred and forty-five CHB patients from the mainland of China between August 2013 and September 2016 who underwent liver biopsy received entecavir therapy and had paired liver biopsy at 78 weeks. We analyzed correlations between HBcrAg and virological and histological variables in hepatitis B e antigen (HBeAg)-positive and HBeAg-negative patients. We also explored the predictors of HBeAg loss after 78 weeks of antiviral therapy. Pearson correlation analysis and logistic forward stepwise regression were the main statistic methods.Results:HBeAg-positive patients (n = 93) had higher baseline HBcrAg (median 7.4 vs. 5.3 log10 U/mL P < 0.001) and greater HBcrAg declines (median 1.6 vs. 0.9 log10 U/mL P= 0.007) than HBeAg-negative patients after 78 weeks of therapy. At baseline, HBcrAg correlated with hepatitis B virus (HBV) DNA in both HBeAg-positive (r = 0.641, P < 0.001) and -negative patients (r = 0.616, P < 0.001), with hepatitis B surface antigen (HBsAg) in HBeAg-positive patients (r = 0.495, P < 0.001), but not with anti-hepatitis B virus core antibody (anti-HBc). Weak correlations existed between HBcrAg, histology activity index (HAI; r = 0.232, P= 0.025), and Ishak fibrosis score (r= -0.292, P= 0.005) in HBeAg-positive patients. At 78 weeks, significant correlations existed only between HBcrAg and anti-HBc in HBeAg-positive (r = -0.263, P = 0.014) and HBeAg-negative patients (r= -0.291, P= 0.045). Decreased HBcrAg significantly correlated with reduced HBV DNA (r= 0.366, P= 0.001; r= 0.626, P < 0.001) and HBsAg (r = 0.526, P = 0.001; r = 0.289, P = 0.044) in HBeAg-positive and -negative patients, respectively, and with reduced HAI in HBeAg-positive patients (r = 0.329, P = 0.001). Patients with HBeAg loss (n = 29) showed a larger reduction in HBcrAg than those without (median 2.3 vs. 1.3 log10 U/mL, P = 0.001). In multivariate analysis, decreased HBcrAg was an independent predictor of HBeAg loss (P = 0.005).Conclusions:HBcrAg reflects viral replication and protein production. Decreased HBcrAg could predict HBeAg loss after antiviral therapy.Trial registration:Clinical Trials.gov: NCT01962155; https://www.clinicaltrials.gov/ct2/show/NCT01962155?term=NCT01962155&draw=2&rank=1

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简介：摘要：目前，城市建设快速发展，对环境要求也不断提升，这在一定程度上限制了我们平时的用电量。现代科学家研究得到，10千伏电缆是用电上线。但是，如今很多单位包括部分企业的用电量已经超过了这个范围，从而带来一定的故障。本篇文章就10千伏电缆故障进行了分析和处理。

简介：摘要：10kV线路在运行过程中经常会受到多种原因影响，包括但不限于树障、雷击等，无论何种原因都有可能引起线路设备跳闸，对其正常运行产生影响，使得用户的正常用电无法得到保障，降低供电企业的供电稳定性和供电质量，同时也有损于供电企业形象，带来比较大的危害。因此对10kV线路故障的整治策略进行分析，有着重要的研究价值。

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简介：AbstractBackground:Models to predict mortality in trauma play an important role in outcome prediction and severity adjustment, which informs trauma quality assessment and research. Hospitals in China typically use the International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) to describe injury. However, there is no suitable prediction model for China. This study attempts to develop a new mortality prediction model based on the ICD-10-CM lexicon and a Chinese database.Methods:This retrospective study extracted the data of all trauma patients admitted to the Beijing Red Cross Emergency Center, from January 2012 to July 2018 (n = 40,205). We used relevant predictive variables to establish a prediction model following logistic regression analysis. The performance of the model was assessed based on discrimination and calibration. The bootstrapping method was used for internal validation and adjustment of model performance.Results:Sex, age, new region-severity codes, comorbidities, traumatic shock, and coma were finally included in the new model as key predictors of mortality. Among them, coma and traumatic shock had the highest scores in the model. The discrimination and calibration of this model were significant, and the internal validation performance was good. The values of the area under the curve and Brier score for the new model were 0.9640 and 0.0177, respectively; after adjustment of the bootstrapping method, they were 0.9630 and 0.0178, respectively.Conclusions:The new model (China Mortality Prediction Model in Trauma based on the ICD-10-CM lexicon) showed great discrimination and calibration, and performed well in internal validation; it should be further verified externally.

简介：摘要目的探讨黏蛋白痣的临床病理特征。方法回顾性分析2014年1月至2019年12月在中国医学科学院皮肤病医院经临床及组织病理确诊的10例黏蛋白痣患者的临床和病理资料。结果10例黏蛋白痣均为儿童期发病，平均发病年龄6.5岁。7例皮损位于躯干，其中4例位于背部；2例位于四肢，1例躯干、四肢泛发。皮损在局部排列成线状、带状或簇集状，质地柔软至坚硬不等，颜色呈肤色、淡红色和黄色。组织病理检查：10例均表现为真皮内胶原纤维束排列紊乱，其间可见程度不等的黏蛋白沉积，沉积的位置和程度不一，6例在沉积区见胶原纤维增粗、红染，其余4例表现为胶原稀疏、减少；2例出现基底层灶状液化变性，3例出现真皮内不等量成熟脂肪组织等。结论黏蛋白痣的病理主要表现为真皮内程度不等的黏蛋白沉积于杂乱的胶原束间，可与一些其他疾病类似，容易误诊，临床和病理紧密联系可确诊。

简介：摘要：本文归纳总结核电厂安全生产“红线10条”，切实树立安全发展理念，拓展安全宣传渠道和受众面，增强全社会安全意识和自觉行动，进一步动员社会各界共同做好安全生产工作，为庆祝建党一百周年创造良好的安全环境。

简介：摘要：随着时代的发展和经济的进步，人们的工作越来越复杂，生活越来越丰富，所以对于用电的要求也就越来越高，为了促进国家经济发展，提供高电网企业利润，并满足人民群众日常生活生产的用电需求，电能已经是人们日常生活中不可缺少的能源，电能的输配电线路的合理规划也变得至关重要，本文就对10 kV配电网线路的规划设计进行分析，以促进配电