简介：AutoreactiveB房间是在全身的豺狼座erythematosus(SLE)的致病被含有的关键有免疫力的房间之一。除了有害自身抗体(auto-Abs)的生产，B房间作为介绍抗原的房间告知autoreactiveT房间并且分泌大量支持inflammatorycytokines有autocrine和paracrine效果。调制B房间的代理人可能因此具有潜在的治疗学的价值。当前的策略包括指向B房间表面抗原，cytokines支持B房间生长和功能，和B房间和T房间相互作用。在这篇文章，我们在动物和人的研究在SLE考察B细胞的角色，并且我们检验为这个条件的处理作为有希望的策略支持B房间调整的以前的报告。另外，我们在场评估了在人的SLE反对CD20，CD22和B淋巴细胞激发器(BLyS)的代理人的治疗学的功效和安全的临床的试用上的更改。当这些研究的许多的结果仍然保持不确定时，belimumab，对BLyS的人的monoclonal抗体，显示出诺言并且最近被US食物药品管理局为病人作为显示的治疗同意了与对中等SLE温和。无疑，在B房间免疫学的进展将继续带我们到SLE致病的更好的理解和指向B房间的新奇特定的治疗的发展。

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简介：TherearenotabledifferencesintheincidenceandmortalityratesforprostatecancerbetweenAsiaandWesterncountries.Itisalsorecognizedthattherearedifferencesinthinkingwithregardtotreatmentoptions.RecentlyitisalsothecasethatopinionshavebeenreportedconcerningthedifferencesbetweenAsianandWesternpatientswithregardtotheirreactiontoandrogendepletiontherapy(ADT).GiventhatADTisamethodoftreatmentthatfocusesontheeliminationoftestosterone,aninevitablesymptomofitsadministrationistestosteronelosingsyndrome.ItisforthisreasonthatinWesterncountriesADThasonlybeenrecommendedincasesofadvancedormetastaticcancer.Ontheotherhand,inAsia,ADTisusedinrelativelymanycases,includingnon-metastaticlocalizedcancerandinvasivelocalizedcancer.Todate,however,therehasbeenlittlesubstantivediscussionconcerningthisdifferenceinutilizationofADT.ADT-relateddrugsforprostatecancerandthedevelopmentofnewdrugsforcastrationresistantprostatecancer(CRPC)havebeenactivelytestedinrecentyears.ItcouldbethecasethatanalyzingthedifferencesinconceptsaboutADTbetweenAsiaandtheWestcouldcontributetotheeffectiveuseofADT-relateddrugsandalsohelptobuildnewtreatmentstrategiesforprostatecancer.

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简介：Objective:Laser-inducedCoulombexplosionofgoldnanoparticlesforbreastcancerhasbeenstudiedbynanophotolysistechnique.Thisstudyaimedtoinvestigatewhetherlaser-inducedbubbleformationduetoCoulombexplosioncanprovideaneffectiveapproachforselectivedamageofbreastcancerwithgoldnanoparticles.Method:Numericalmethodinvolveslaser-inducedCoulombexplosionofgoldnanoparticles.Differentparametersrelatedtonanophotolysissuchaslaserfluence,tumordepth,clusterradius,laserpulseduration,andbubbleformationisstudiednumerically.NumericalsimulationwasperformedusingMatlab.Results:Thegoldnanoparticlesof10,20,30,40,and50nminradiuscouldpenetrateintotumor1.14,1.155,1.189,1.20and1.22cmindepthrespectively.Themaximumpenetrationdepthintumorcouldbeobtainedwithnanoparticlesof50nmradius.Shortlaserpulseof40nswithnanoparticlesof10nmradiuscouldpenetrateintotumor1.14cmindepth.Bubbleswitharadiusof9μmcouldeffectivelykillbreastcancercellswithoutdamaginghealthyones.Thebubbleradiusincreasedfrom4to9μmwithanincreaseinpulsedurationintherangeof10to30ns.Conclusions:Goldnanoparticleswithincreasingradiusandbubbleformationforselectivedamageofbreastcancercellsaresuccessfullyprobed.Thepresentcalculatedresultsarecomparedwithotherexperimentalfindings,andgoodcorrelationisfoundbetweenthepresentworkandpreviousexperimentalvalues.Itwasdemonstratedthatbubbleformationintumormayfurtherincreasetheefficacyofbreastcancertreatment.

简介：观察针灸的临床的效果的目的在治疗长期的湿疹与acupoint注射治疗结合了。七十个病人随机被划分成二个组的方法。在治疗组的36个盒子在针灸方面被对待，acupoint注射治疗并且与洋梅花针拍，当在控制组的34个盒子与Halometasone的Loratadine正热门申请的口头的管理被对待时，啪啪撞击。在三星期的治疗，药品和显著的有效的率和全部的有效的率以后的结果是分别地，80.6%和97.2%在治疗组织，对47.1%和79.4%在控制组织。在在二个组之间的药品和显著的有效的率和全部的有效的率的差别是统计上重要的(所有P<0.05)。没有明显的不利反应在治疗期间出现在二个组。结论针灸正acupoint注射治疗为有安全地的高度的长期的湿疹是有效的。

简介：Objective:ToassesstheeffectofantiviraltherapyforhepatitisBvirus(HBV)-relatedhepatocellularcarcinoma(HCC)afterradicalhepatectomy.Methods:Atotalof478HBV-relatedHCCpatientstreatedbyradicalhepatectomywereretrospectivelycollected.Patientsinthetreatmentgroup(n=141)receivedpostoperativelamivudinetreatment(100mg/d),whereaspatientsinthecontrolgroup(n=337)didnot.Recurrence-freesurvival(RFS)rates,overallsurvival(OS)rates,treatmentsforrecurrentHCCandcauseofdeathwerecomparedbetweenthetwogroups.Propensityscorematching(PSM)analysiswasalsoconductedtoreduceconfoundingbiasbetweenthetwogroups.Results:The1-,3-,and5-yearRFSratesdidn’tsignificantlydifferbetweenthetwogroups(P=0.778);however,the1-,3-,and5-yearOSratesinthetreatmentgroupweresignificantlyhigherthanthoseinthecontrolgroup(P=0.002).Similarresultswereobservedinthematcheddata.SubgroupanalysisshowedthatantiviraltreatmentconferredasignificantsurvivalbenefitforBarcelonaClinicalLiverCancerstageA/Bpatients.FollowingHCCrecurrence,morepeopleinthetreatmentgroupwereabletochoosecurativetreatmentsthanthoseinthecontrolgroup(P=0.031).Forcauseofdeath,fewerpeopleinthetreatmentgroupdiedofliverfailurethanthoseinthecontrolgroup(P=0.041).Conclusion:PostoperativeantiviraltherapyincreaseschancesofreceivingcurativetreatmentsforrecurrentHCCandpreventsdeathbecauseofliverfailure,therebysignificantlyprolongingOS,especiallyinearly-orintermedian-stagetumors.

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简介：BackgroundSeveralstudieshavereportedanassociationofhyperglycemiawithincreasedmortalityandcomplicationsinhospitalpatientswithacutecoronarysyndrome(ACS).However,theinfluenceofstresshyperglycemia(SH)onthemedium-andlong-termprognosesinACSpatientshasnotyetbeendetermined.MethodsRandomvenousbloodglucoselevelsweredeterminedin433ACSpatientsandthepatientsweredividedintotwogroupsbasedonbloodglucoseresultsanddiseasehistories.The171patientsincludedintheexperimentalgrouphadnohistoryofdiabetes,hadnodiabetesand/orglucosemetabolismdisordersduringhospitalizationandfollow-upandhadfastingbloodglucoselevelsof≥7.0mmol/Landrandombloodglucoselevels≥11.1mmol/L.The262patientsincludedinthecontrolgrouphadnohistoryofdiabetes,hadnodiabetesand/orglucosemetabolismdisordersduringhospitalizationandfollow-up,andhadfastingbloodglucoselevels<6.1mmol/Landrandombloodglucoselevels<7.8mmol/L.Basicclinicalinformation,coronaryangiographiclesioncharacteristics,PCIsuccessrate,complicationrate,incidenceandmorbidityrateofcardiovasculareventsduringthehospitalizationperiodand6yearsoffollow-upwerecomparedbetweenthetwogroups.ResultsTherewasnosignificantdifferenceinage,genderordiseasehistorybetweenthetwogroups.Thetriglyceridelevelsandtheleftventricularejectionfractionsweresignificantlyhigher(P=0.00)andsignificantlylower(P=0.03)intheexperimentalgroupthaninthecontrolgroup,respectively.BothgroupsweresubjectedtocoronaryangiographyandPCI.ThePCIsuccessratesofthetwogroupsdidnotdiffersignificantly(P=0.63).TheexperimentalgrouphadmoretypeB2lesions,butfewertypeAlesionscomparedwiththecontrolgroup.Theexperimentalgrouphadsignificantlymorestentsimplantedcomparedwiththecontrolgroup(P<0.05).Thecardiovasculareventsweresignificantlyincreased(P=0.01)intheexperimentalgroupcomparedwiththecontrolgroup1yearafterdischarge.Thein

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简介：BackgroundLeftbundlebranchblock(LBBB)resultsinanalteredpatternofleftventricular(LV)activationandsubsequentcontraction.CardiacsynchronyandcardiacfunctionaredeterioratedbyLBBB.However,theeffectofLBBBhistoryonprogressiveheartdysfunctionandclinicalefficacyofcardiacresynchronizationtherapy(CRT)insuchpatientsarenotclear.InthisstudyweexploretheclinicalefficacyandpredictorofcardiacresynchronizationtherapyinLBBBheartdysfunction.MethodsTwenty-sevenLBBBpatientswithsevereheartfailureweretreatedwithCRT.Twenty-sixLBBBpatientswithoutCRTservedascontrol.During6monthsfollow-up,ECG,plasmaNT-proBNPandechocardiogramindexesweremeasured.ResultsComparedwithbaseline,NYHAfunctionalclassof23patients(85.2%)wasimprovedinCRTgroup.Comparedwithbaselineandcontrol,QRSduration(QRSd)wassignificantlymorenarrow(P=0.023,P=0.019),NT-proBNPwassignificantlylower(P=0.011,P=0.009),ventricularseptaltoleftventricularposteriorwalldelaytimeandleftventriculardyssynchronyindex(Ts-SD)weresignificantlyworse(P<0.05);leftventricularejectionfraction,leftventricularend-systolicvolume,mitralregurgitationareaweresignificantlyimprovedinCRTgroup(P<0.05).whentheLBBBhistorywas≥2yearsandQRSd≥155ms,thesensitivityandspecificityofCRTsuper-responsewere53.4%and85.6%respectively.ConclusionsCRTcanimprovethesynchronizationandhemodynamicofLBBBpatientswithheartdysfunction,theLBBBhistory≥2yearsandQRSd≥155msareoneoftheCRTsuper-responsepredictors.

简介：PURPOSE:Todeterminethesafetyandefficacyofgefitinib,anepidermalgrowthfactorreceptor(EGFR)tyrosinekinaseinhibitor,incombinationwithradiationfornewlydiagnosedglioblastoma(GBM)patients.METHODSANDMATERIALS:BetweenMarch21,2002,andMay3,2004,RadiationTherapyOncologyGroup(RTOG)0211enrolled31and147GBMpatientsinthephase1and2arms,respectively.Treatmentconsistedofdailyoralgefinitnibstartedatthetimeofconventionalcranialradiationtherapy(RT)andcontinuedpostRTfor18monthsoruntilprogression.Tissuemicroarraysfrom68caseswereanalyzedforEGFRexpression.RESULTS:Themaximumtolerateddose(MTD)ofgefitinibwasdeterminedtobe500mginpatientsonnon-enzyme-inducinganticonvulsantdrugs(non-EIAEDs).Allpatientsinthephase2componentweretreatedatagefitinibdoseof500mg;patientsreceivingEIADSscouldbeescalatedto750mg.Themostcommonsideeffectsofgefitinibincombinationwithradiationweredermatologicandgastrointestinal.Mediansurvivalwas11.5monthsforpatientstreatedperprotocol.Therewasnooverallsurvivalbenefitforpatientstreatedwithgefitinib+RTwhencomparedwithahistoricalcohortofpatientstreatedwithRTalone,matchedbyRTOGrecursivepartitioninganalysis(RPA)classdistribution.Youngeragewassignificantlyassociatedwithbetteroutcome.Perprotocolstratification,EGFRexpressionwasnotfoundtobeofprognosticvalueforgefitinib+RT-treatedpatients.CONCLUSIONS:TheadditionofgefitinibtoRTiswelltolerated.MediansurvivalofRTOG0211patientstreatedwithRTwithconcurrentandadjuvantgefitinibwassimilartothatinahistoricalcontrolcohorttreatedwithradiationalone.

简介：BackgroundInclopidogrel-treatedpatientsundergoingpercutaneouscoronaryintervention(PCI),theeffectofconcomitantuseofPPIsonprognosisremainsunclear.MethodsFromJuly2010toJune2012,600patientsafterimplantationofdrug-elutingstent(DES)wereassignedto3groupsaccordingtothemedicaltherapy:group1(n=200)receivedduralantiplatelettherapy(DAPT)alone(aspirine100mgdailyplusclopidogrel75mgdaily),group2(n=199)receivedDAPTpluspantoprazole20mgdailywhilegroup3(n=201)receivedDAPTplusomeprazole20mgdailyfor1year.Theprimaryoutcomewasmajoradversecardiovascularevents(MACEs)whichcomposeofdeath,nonfatalmyocardialinfarction(MI),nonfatalstroke,targetvesselrevascularization(TVR)orstentthrombosis(ST)at1year.PlateletreactivitywasevaluatedforallpatientsbeforePCIand1yearafterPCI.ResultsTherewasnosignificantdifferenceintheplateletreactivityamongthe3groupsat1-yearfollow-up(27.3%versus29.9%versus29.3%,respectively,P=0.339).Neitherwastheresignificantdifferenceintheincidenceof1-yearMACEs(13%versus14.6%versus12.4%,respectively,P=0.809).ConclusionsConcomitantuseofpantoprazoleoromeprazoledidnotinfluenceplateletreactivityorclinicaleventsinpatientsreceivingDAPTafterimplantationofDES.

简介：Theacquisitionofsecondarychromosomalaberrationsinchronicmyeloidleukemia(CML)patientswithPhiladelphiachromosome-positive(Ph+)karyotypesignifiesclonalevolutionassociatedwiththeprogressionofthediseasetoitsacceleratedorblasticphase.Therefore,theseaberrationshaveclinicalandbiologicalsignificance.T(3;12)(q26;p13),whichisarecurrentchromosomalaberrationobservedinmyeloidmalignancies,istypicallyassociatedwithdysplasiaofmegakaryocytes,multilineageinvolvement,shortdurationofanyblasticphase,andextremelypoorprognosis.Wehaveidentifiedarecurrentreciprocaltranslocationbetweenchromosomes3and12withdifferentbreakpointatbands3q21inthemalignantcellsfroma28-year-oldman.ThepatientwasinitiallydiagnosedashavingPh+CMLinthechronicphase.Thet(3;12)(q21;p13)translocationoccurred4yearsafterthepatientwasfirstdiagnosedwithCMLwhileundergoingtyrosinekinaseinhibitortherapy.Weconfirmedthet(3;12)(q21;p13)translocationviafluorescenceinsituhybridizationassaybyusingwhole-chromosomepaintprobesforchromosomes3and12.Ourfindingsdemonstratethat,similartootherrecurrenttranslocationsinvolving3q26suchast(3;3)andt(3;21),thet(3;12)(q21;p13)translocationisimplicatednotonlyinmyelodysplasticsyndromeandacutemyeloidleukemiabutalsointheprogressionofCML.Thesefindingsextendthediseasespectrumofthiscytogeneticaberration.