简介：Esophagealcancerhasbeenreportedastheninthmostcommonmalignancyandranksasthesixthmostfrequentcauseofdeathworldwide.Esophagealcancertreatmentinvolvessurgery,chemotherapy,radiationtherapy,orcombinationtherapy.Novelstrategiesareneededtoboosttheoncologicoutcome.Recentadvancesinthemolecularbiologyofesophagealcancerhavedocumentedtheroleofgeneticalterationsintumorigenesis.Oncogenesserveapivotalfunctionintumorigenesis.Targetedtherapiesaredirectedattheuniquemolecularsignatureofcancercellsforenhancedefficacywithlowtoxicity.RNAinterference(RNAi)technologyisapowerfultoolforsilencingendogenousorexogenousgenesinmammaliancells.RelatedresultshaveshownthattargetingoncogeneswithsiRNAs,specificallythemRNA,effectivelyreducestumorcellproliferationandinducesapoptoticcelldeath.Thisarticlewillbrieflyreviewstudiesonsilencingtumorenhancergenesrelatedtotheinductionofesophagealcancer.
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