简介：ＡＣＡＳＥＲＥＰＯＲＴＯＦＰＲＩＭＡＲＹＳＱＵＡＭＯＵＳＣＡＲＣＩＮＯＭＡＯＦＴＨＥＥＮＤＯＭＥＴＲＩＵＭＨｅＷｅｎｃｕｉ何文翠；ＷｕＪｉｎｇ吴静；ＣｈａｎｇＪｉｅ唱捷；（ＴｈｅＳｅｃｏｎｄＡｆｆｉｌｉａｔｅｄＨｏｓｐｉｔａｌ，Ｘｉ’ａｎＭｅｄｉｃａ...

简介：Enterovesicalfistulasarenotuncommoninpatientswithinflammatoryormalignantcolonicdisease,however,fistulassecondarytoprimarybladdercarcinomasareextremelyrare.Wehereinreportedapatientpresentingwithintractableurinarytractinfectionduetoenterovesicalfistulaformationcausedbyasquamouscellcarcinomaoftheurinarybladder.Thispatientunderwentenblocresectionofthebladderdomeandinvolvedileum,andrecovereduneventfullywithouturinarycomplaint.Tothebestofourknowledge,thisisthefirstcasereportedintheliterature.

简介：Esophagealcancerisoneofthemostfataldiseasesworldwidemainlybecauseofitsrapidprogressionandpoorprognosis.AlthoughtheincidenceofesophagealadenocarcinomahasmarkedlyriseninNorthAmericaandEuropeinthepastseveraldecades,esophagealsquamouscellcarcinomaisstillthepredominantsubtypeofesophagealcancer,especiallyinChina.Itaccountsformorethan90%ofallesophagealsquamouscellcarcinomacasesinChina.Geographicaldifferentiationisoneofthemostdistinctivecharacteristicsofesophagealcancer.Theprogression,riskfactors,andprognosisofthesetwosubtypesofesophagealcancerdiffer.Thisstudyreviewstheepidemiology,etiology,andpreventionofesophagealsquamouscellcarcinomainChina,therebyprovidingsystematicreferencesforpolicy-makerswhowilldecideonissuesofesophagealcancerpreventionandcontrol.

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简介：Objective:Tostudytheexpressionofvascularendothelialgrowthfactor(VEGF)andmicrovesseldensity(MVD)inesophagealsquamouscellcarcinoma(ESCC)andclarifytheassociationofVEGFexpressionwiththeangiogenesisandprognosticvalueofthisdisease.Methods:Eighty-twocaseswithprimaryESCCtreatedwithradicaloperationinDepartmentofSurgeryfromJan1981throughMay1994wereenrolled.VEGFexpressionandMVDvaluewereexaminedbyimmunohistochemicalstaining,thestreptavidin-biotinperoxidasecomplexmethod(SPmethod),usinganti-VEGFpolyclonalantibodyandanti-Factor-VIIIantibody,respectively.WealsoanalyzedtherelationshipbetweenVEGFexpressionandMVDvalueandpostoperativesurvivalrateofpatients.Results:Ofthe82cases,63.4%casesshowedpositiveforVEGFintumorcellsandthemedianofMVDintumorwas37(9-150)·mm-2.TherewasaclosecorrelationbetweenMVDandVEGF(P=0.001).The5-yearsurvivalrateofpatientswithlowandhighMVDwas34.1%and12.2%,respectively.The5-yearsurvivalratewas46.7%inpatientswithVEGF-negativetumorand11.5%inpatientswithVEGF-positivetumor.Thesedifferenceswerestatisticallysignificant(P=0.017andP<0.001,respectively).Conclusion:InESCC,angiogenesisismediatedmainlybyVEGFandVEGFmaybeassociatedwithtumorprogressionandincreasedmalignancyviaangiogenesis.

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简介：瞄准：在食道的有鳞的房间癌(ESCC)调查midkine的表示并且与clinicopathological特征分析它的关系。方法：RT-PCR和免疫细胞化学的染色被用来分别地在EC109房间检测midkinemRNA和蛋白质的表示。然后，在ESCC样品的66种情况中的midkine的表示被免疫组织化学对人的midkine用单音的同种细胞的抗体检测。结果：Midkine被RT-PCR和免疫细胞化学在EC109房间表示。免疫反应在56.1%被检测(37/66)ESCC样品。midkine的表示在肿瘤房间的细胞质被发现。尤其是，midkine的紧张在充满容器和肿瘤的入侵的边阶的区域是更强壮的。Midkine更强烈地比在中等并且糟糕区分的肿瘤在很好区分的肿瘤(76.9%)被表示(43.1%和41.2%，分别地)(P<0.05)。在midkine之间没有统计上重要的关联在ESCC的表示和性，年龄，临床的阶段，淋巴节点转移或幸存。结论：Midkine完了在ESCC表示了。它可以在肿瘤血管生成和侵略起一个作用。midkine的表示在ESCC与肿瘤细胞分化被相关。肿瘤房间区分越多糟糕，midkine表示越多weaker。

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简介：Laryngealsquamouscellcarcinoma(LSCC)remainsahighlymorbidandfataldisease.Historically,ithasbeenamodelexamplefororganpreservationandtreatmentstratificationparadigms.Unfortunately,survivalforLSCChasstagnatedoverthepastfewdecades.Astheeraofnext-generationsequencingandpersonalizedtreatmentforcancerapproaches,LSCCmaybeanidealdiseaseforconsiderationoffurthertreatmentstratificationandpersonalization.Here,wewilldiscusstheimportanthistoryofLSCCasamodelsystemfororganpreservation,uniqueandpotentiallytargetablegeneticsignaturesofLSCC,andmethodsforbringingstratified,personalizedtreatmentstrategiestothe21~(st)century.

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简介：Objective:Thisstudyaimstoinvestigatethetruth-tellingstatusandtherelevantfactorsofesophagealsquamouscellcarcinoma(ESCC)patientsinHenan,China.Methods:Across-sectionalstudyfromApriltoJune2015usingquestionnaireswasgivento301familymembersofhospitalizedESCCpatientsbasedinthreeaffiliatedhospitalsofZhengzhouUniversity(i.e.,TheFirstHospital,TheSecondHospital,andTumorHospital)andAnyangTumorHospital.Results:Amongthe41.9%(126/301)hospitalizedESCCpatientswhoknewoftheirtruediagnoses,only4.0%patientswereinformedbytheircorrespondingresponsibledoctors,39.7%bytheirfamilymembers,and56.3%bythemselves.UnivariateanalysesshowedthatdisclosureofconfirmedESCCdiagnosistopatientswascorrelatedwithgender,familyhistoryofcancer(FHC),educationlevel,vocation,hospitaladministrativelevel,andattitudesoffamilymembers(P<0.05).Furthermore,multivariateanalysisindicatedthatattitudeoffamilymemberswasthemostimportantandanindependentfactorfordiagnosisdisclosure.ThosepatientswithanegativeFHC,under-education,manualoccupation,advancedstages,andhospitalizedinmunicipalhospitalsexhibitedalowrateoftruthtelling.Conclusions:TruthtellingforESCCpatientsinHenanisnotprevalentandmaybeimprovedthroughconsultationwithfamilymembers,particularlyforpatientswithanegativeFHC,pooreducation,manualoccupation,andadvancedstages.

简介：瞄准：Disabled-2(DAB2)是在卵巢的癌症识别否定地影响生长因素和块地岬活动的致有丝分裂信号转导变异的候选人tumor-suppressor基因。在最近的研究，我们用cDNA在ESCC观察了DAB2抄本的下面规定微数组。在现在的学习，我们试图在食道的肿瘤发生决定DAB2蛋白质的损失的临床的意义，假设那个DAB2倡导者调停hypermethylation的基因silencing可以说明蛋白质的损失。方法：DAB2表示被免疫组织化学在50主要食道的有鳞的房间分析癌(ESCC)，30不同增生，15发育异常和10非恶意的食道的纸巾。决定倡导者hypermethylation是否在ESCC贡献DAB2表示的损失，DAB2倡导者的甲基化地位用methylation特定的PCR在DAB2免疫否定的肿瘤被分析。结果：DAB2蛋白质的损失在5/30(17%)被观察增生，10/15(67%)发育异常和34/50(68%)ESCC。DAB2蛋白质的重要损失从食道的正常粘膜被观察到增生，发育异常和侵略癌症(P(趋势)<0.001)。DAB2的倡导者hypermethylation在10中的2个被观察(20%)DAB2免疫否定的ESCC。结论：DAB2蛋白质表示的损失发生在食道的癌症的开发的早pre肿瘤的阶段并且在致瘤的小径下面被支撑。在ESCC的很少发生的DAB2倡导者甲基化建议渐成说基因silencing仅仅是在ESCC引起DAB2表示的损失的机制之一。

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简介：Eosinophiliculceroforalmucosa(EUOM)isanonspecificclinicalappearance,whichappearstobefrequentlyunrecognizedormisdiagnosedusuallyassquamouscellcarcinoma(SCC),especiallyinoldpatients.Itisarareself-limitedbenignulcerativedisease,anditischaracterizedwiththeinfiltrationofeosinophilicleukocytesmixedwithotherinflammatorycells,1,2suchasthemitoticallyactivelargemononuclearcellswithroundorovoidpalenucleus.Thiscelltype,ofteninterpretedasahistiocyte,confoundsthehistologicevaluationandoccasionallyleadstotheerroneousdiagnosisoflymphohistiocyticmalignantcondition.Althoughithasassumedthattraumaisanimportantetiologicfactor,theexactpathogenesisremainsunclear.3ThemorbidityofthisdiseaseislowandtherearefewChineseliteraturesaboutit,4soitisnecessarytopaymoreattentiontoit.Inthisarticle,3outof5casesofEUOMaremisdiagnosedasSCC,andwewillreporttherecordsinordertoidentifyitfromSCCwell.

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简介：AbstractBackground:Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive cancers without effective therapy. To explore potential molecular targets in ESCC, we quantified the mutation spectrum and explored the relationship between gene mutation and clinicopathological characteristics and programmed death-ligand 1 (PD-L1) expression.Methods:Between 2015 and 2019, 29 surgically resected ESCC tissues and adjacent normal tissues from the Fourth Hospital of Hebei Medical University were subjected to targeted next-generation sequencing. The expression levels of PD-L1 were detected by immunohistochemistry. Mutational signatures were extracted from the mutation count matrix by using non-negative matrix factorization. The relationship between detected genomic alterations and clinicopathological characteristics and PD-L1 expression was estimated by Spearman rank correlation analysis.Results:The most frequently mutated gene was TP53 (96.6%, 28/29), followed by NOTCH1 (27.6%, 8/29), EP300 (17.2%, 5/29), and KMT2C (17.2%, 5/29). The most frequently copy number amplified and deleted genes were CCND1/FGF3/FGF4/FGF19 (41.4%, 12/29) and CDKN2A/2B (10.3%, 3/29). By quantifying the contribution of the mutational signatures to the mutation spectrum, we found that the contribution of signature 1, signature 2, signature 10, signature 12, signature 13, and signature 17 was relatively high. Further analysis revealed genetic variants associated with cell cycle, chromatin modification, Notch, and Janus kinase-signal transducer and activator of transcription signaling pathways, which may be key pathways in the development and progression of ESCC. Evaluation of PD-L1 expression in samples showed that 13.8% (4/29) of samples had tumor proportion score ≥1%. 17.2% (5/29) of patients had tumor mutation burden (TMB) above 10 mut/Mb. All samples exhibited microsatellite stability. TMB was significantly associated with lymph node metastasis (r = 0.468, P = 0.010), but not significantly associated with PD-L1 expression (r = 0.246, P = 0.198). There was no significant correlation between PD-L1 expression and detected gene mutations (all P > 0.05).Conclusion:Our research initially constructed gene mutation profile related to surgically resected ESCC in high-incidence areas to explore the mechanism underlying ESCC development and potential therapeutic targets.

简介：AbstractObjective:We present the largest population based study of sinonasal squamous cell carcinoma (SCC) to identify risk factors for presentation with nodal metastasis.Methods:The National Cancer Database (NCDB) was used for this study. Location codes corresponding to the nasal cavity and paranasal sinuses and histology codes representing SCC malignancy were queried. Logistic regression analysis was performed to identify factors associated with presentation with nodal metastasis.Results:6448 cases met inclusion criteria. Nodal metastasis at presentation was seen in 13.2% of patients, with the sinus subsite (19.3%) being a significant risk factor for nodal metastasis at presentation when compared to the nasal cavity (7.9%). Logistic regression analysis showed black, uninsured and Medicaid patients were more likely than white and privately insured patients, respectively, to present with nodal metastasis.Conclusions:In sinonasal SCC, the sinus subsite has a significantly increased risk of nodal metastasis compared to the nasal cavity. Black race, uninsured and Medicaid patients are more likely to have nodal metastasis at presentation.