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简介：AimingtoprovideameasurableserviceQualityofService(QoS)evaluatingmethodforserviceinventorymanagement,thispaperproposesanewmobileServiceUtilityModel(SUM),considerstheserviceandbusinesslayerelementsintotheserviceutilityinfluenceprofile,andproposesanself-adaptiveserviceinventorymanagementalgorithmasaQoScontrolschemebasedonSUM.ItcanbeconcludedfromthesimulationresultthattheserviceinventoryutilitycanbefullyreflectedbySUMandthewholesystemefficiencyisgreatlyincreasedbyusingSUMastheadaptiverule.

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简介：1.IntroductionCoalislistedinChina’senergypolicyasthepredominantfueltobeusedforthermalpowergeneration.ItincludesnearlythewholespectrumofcoalsthatChinahas,rangingfromanthracitetobrowncoal.ThisposesasituationtoChina’sutilityboilermanufacturersthattheirproductshavetocopewithallkindsofcoalavailable.Chinaisnowproducingafullrangeofutilityboilerswithca-pacitiesfrom35t/hthrough2000t/h.Theyhavesuccessfullyburnedanthracitieswithvolatilemattergreaterthan7%andlowgradecoalswithhighmoistureandhighashcontents.Theyburnbituminouscoalsandligniteswithsatisfactoryefficacy.

简介：ThemodelingmethodologiesandcalculationofdynamicresponseofundergroundstructureunderRayleighwavesisinvestigatedinthispaper.FirstthefreefieldresponsesunderRayleighwavesareanalyzedandthenumericalresultsagreewellwiththetheoreticalresults.Then,theapproximateRayleighwavesareputforwardbasedonthepreliminaryre-search,andRayleighwavefieldisobtainedthroughfastFouriertransformtechnique.Takingautilitytunnelasanexample,itsdynamicresponsesunderRayleighwavesiscalculatedbyABAQUS.Theresultsdemonstratethatbendingdeformationisthemaincomponentofstructuraldeformationandthedeformationatthetopofthestructureisabouttwiceasmuchasthatatbottomofthestructure.Theeffectofsoil-structureinterfaceandtheburieddepthofundergroundstructurearealsoinvesti-gatedviaparameteranalysis.Fortheshallowburiedundergroundstructures,Rayleighwavescanbethekeyfactortocontroltheresponsesanddamageofthestructure.

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简介：AbstractThe incidence of septic acute kidney injury (AKI) is increasing, it has become a major threat to human health because of its acute onset, poor prognosis, and high hospital costs. The most common cause of AKI in critical-care units is sepsis. Septic AKI is a complex and multi-factorial process; its pathogenesis is not fully understood. In sepsis, the destruction of mucosal barriers, intestinal flora disorders, intestinal ischemia/reperfusion injury, use of antibiotics, and lack of intestinal nutrients lead to an inflammatory reactions that in turn affects the metabolism and immunity of the host. Such changes further influence the occurrence and development of AKI. New technology is enabling various detection methods for intestinal flora. Clinical application of these methods in septic renal injury is expected to clarify the relationship among pathogenesis, disease progression mechanism, and intestinal flora.

简介：ObjectiveToreportuseoftheVibrantSoundbridge(VSB)inpatientswithcongenitaldeformationofthemiddleandouterearsandinvestigateitsutilityinthispatientpopulation.MethodFourpatientswithcongenitaldeformationofmiddleandouterearsunderwentVSBimplantation.Allweremale(aged3-18years,average13.5years)andoperatedontheleftside.Malformationwasbilateralin3patientsandunilateralin1patient.Surgicaltechniquesweremodifiedtoaccommodateeachpatient’suniqueconditionsandneeds.Theimplantsitewasapproachedviathefacialrecessin3patientsandthrougharetro-facialnerveroutein1patient.TheVSBimplantwasconnectedtoeitherthestapes(2cases)ortheroundwindow(2cases).PuretoneandspeechaudiometryresultsanddailycommunicationcapabilitiesbeforeandafterVSBactivationwerecompared.ResultsTheoperationsweresuccessfulinallpatients,withnocomplications.ThepatientcommunicationlevelimprovedsignificantlyafterVSBactivation.Averageairconductionpuretonethresholdorconditionedreflexaudiometrythresholdimprovedby35dBinthe0.25-4kHzrange,from69dBHLbeforeVSBactivationto34dBHLafter.Thesentencerecognitionrateinquietat65dBSPLwentupto86%from0%withoutVSBforpatientswithbilateraldeformationandremainedat100%forthepatientwithunilateraldeformity.However,forthelatterpatient,therateimprovedto20%from0%withoutVSBinnoise(-8dBSNR).ConclusionVSBisanexcellentsolutionforimprovinghearinginpatientswithcongenitaldeformationofmiddleandouterears.Operationcanbecompletedandgoodresultscanbeachievedeveninpatientswithuniqueconditionsandneeds.

简介：Duetodramaticallyincreasinginformationpublishedinsocialnetworks,privacyissueshavegivenrisetopublicconcerns.Althoughthepresenceofdifferentialprivacyprovidesprivacyprotectionwiththeoreticalfoundations,thetrade-offbetweenprivacyanddatautilitystilldemandsfurtherimprovement.However,mostexistingstudiesdonotconsiderthequantitativeimpactoftheadversarywhenmeasuringdatautility.Inthispaper,wefirstlyproposeapersonalizeddifferentialprivacymethodbasedonsocialdistance.Then,weanalyzethemaximumdatautilitywhenusersandadversariesareblindtothestrategysetsofeachother.Weformalizeallthepayofffunctionsinthedifferentialprivacysense,whichisfollowedbytheestablishmentofastaticBayesiangame.Thetrade-offiscalculatedbyderivingtheBayesianNashequilibriumwithamodifiedreinforcementlearningalgorithm.Theproposedmethodachievesfastconvergencebyreducingthecardinalityfromnto2.Inaddition,thein-placetrade-offcanmaximizetheuser'sdatautilityiftheactionsetsoftheuserandtheadversaryarepublicwhilethestrategysetsareunrevealed.Ourextensiveexperimentsonthereal-worlddatasetprovetheproposedmodeliseffectiveandfeasible.

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简介：前列腺癌症(PCa)是在在西方的发达国家的人之中的最普通的癌症之一，它的发生在世界的许多另外的部分更加增加了，包括中国。PCa的病原学大部分是未知的，但是被认为是multifactorial，在继承遗传起一个重要作用的地方。在这篇文章，我们简短首先从家庭聚集和基因危险性的研究考察结果到PCa。我们然后，从连接的稀罕、高外显率的PCa危险性基因的翻新的胎面钥匙调查结果在PCa家庭学习。我们把这篇文章的重要部分奉献给在PCa情况和控制中从基因协会研究总结普通、低外显率的PCa联系风险的单个核苷酸的多型性(SNP)的发现，特别那些从染色体宽的协会研究(GWAS)。这篇文章的一个强壮的焦点是在这些含有的基因标记的潜在的临床的用途上考察文学。大多数这些出版研究用在为前列腺活体检视决定需要从多重联系风险的SNP和它的用途导出的一个基因分数描述了PCa风险评价。最后，我们评论基因分数的最新建议的概念；观点是为基因倾向把它当作一个标记，类似于家庭历史，而非一个诊断标记到从非癌症病人区别PCa病人。到日期的可得到的证据建议那个基因分数比家庭历史是一个目的和PCa的继承风险的更好的测量。这篇文章的另一个唯一的特征是在中国、日本的人口的PCa的基因协会研究的包括。

简介：BasedontheanalysisoftheproblemsintraditionalGPmodel,thispaperprovidesthemodelwiththeutilityfunctionofthedecision-makerandcomparesthismodelwiththeonepresentedinreferencearticle[1].

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简介：Preoperativestagingoftheaxillainwomenwithinvasivebreastcancerusingultrasound-guidedneedlebiopsy(UNB)identifiesapproximately50%ofpatientswithaxillarynodalmetastasespriortosurgicalintervention.Althoughmoderatelysensitive,itisahighlyspecificstagingstrategythatisrarelyfalsely-positive,henceapositiveUNBallowspatientstobetriagedtoaxillarylymph-nodedissection(ALND)avoidingpotentiallyunnecessarysentinelnodebiopsy(SNB).Inthisreview,weextendourpreviousworkthroughanupdatedliteraturesearch,focusingonstudiesthatreportdataonUNButility.Basedondatafor10,934breastcancerpatients,sourcedfrom35studies,apositiveUNBallowedtriageof1,745cases(simpleproportion16%)toaxillarysurgicaltreatment:theutilityofUNBwasamedian19.8%[interquartilerange(IQR)11.6%-26.7%]acrossthesestudies.Wealsomodelleddatafromasubgroupofstudies,andestimatedthatamongstpatientswithmetastasestoaxillarynodes,theoddsratio(OR)forhighnodaldiseaseburdenforapositiveUNBversusanegativeUNBwas4.38[95%confidenceinterval(95%CI):3.13,6.13],P<0.001.Fromthismodel,theestimatedproportionwithhighnodaldiseaseburdenwas58.9%(95%CI:50.2%,67.0%)forapositiveUNB,whereastheestimatedproportionwithhighnodaldiseaseburdenwas24.6%(95%CI:17.7%,33.2%)ifUNBwasnegative.Overall,axillaryUNBhasgoodclinicalutilityandapositiveUNBcaneffectivelytriagetoALND.However,theevolvinglandscapeofaxillarysurgicaltreatmentmeansthatUNBwillhaverelativelylessutilitywheresurgeonshavemodifiedtheirpracticetoomissionofALNDforminimalnodalmetastaticdisease.

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简介：Amlodipine/valsartan(Aml/Val)single-pillcombination(SPC)therapyhasbeenwidelyusedandstudiedinclinicalpracticeinrecentyears.ThisarticlereviewstheChineseandEnglishliteratureontheclinicaluseofAml/ValSPCtherapyinChinesehypertensivepatients.Accordingtofivestudiesconcerningtheefficacyandsafetyofthistreatment,Aml/ValSPCtherapywasmoreefficaciousthanmonotherapywithvalsartan,amlodipine,orthenifedipinegastrointestinaltherapeuticsystem.Thistreatmentshowedgreaterbloodpressure-loweringeffects,ahigherbloodpressurecontrolrate,andahigherresponserate.Aml/ValSPCtreatmentwaswelltolerated,withadverseeventratessimilartothoseofmonotherapywithvalsartanoramlodipineandsignificantlyrareradverseeventscomparedwiththenifedipinegastrointestinaltherapeuticsystem.Aml/ValSPCisahighlyefficaciousandwell-toleratedantihypertensivetreatmentinChinesehypertensivepatients.

简介：Wediscussasingle-periodinventorysystemwithageneralS-shapedutilityfunctionandexponentialdemand.Itisshownthatthereexistsastate-dependentorder-up-topolicytobeoptimal.Behaviorsofoptimalpolicyareillustratedbyanumericalexample.