简介：ThediscoveryofthehomeoboxmotifanditspresenceineachgeneoftheHoxclustersrevolutionizedthefieldsofdevelopmentalbiologyandevolutionarydevelopmentalbiology(1,2),providingarapidentranceintoinvestigatingthemechanismsofdevelopmentofalmostanyanimaltaxonaswellasdramaticallyalteringconceptionsontheextentofgeneticconservationacrosstheanimalkingdom.

简介：ItisoutofquestionthatChinahasachievedconsiderableadvancementsinscienceandtechnology.Theworldwidespreadof"MadeinChina"thatgetsonthewesterncountries'nervesisagoodillustration.However,althoughcomparativelybetterthansomeotherdevelopingcountries,wehavetofacethesituationthatscienceandtechnologyinsuchagreatnationasChinaisstillseriouslylaggedbehind,lackinggreatbreakthroughsandtop-rankingmastersandleaders.That'swhywefeeluneasyinfrontofinternationalcolleagues.

简介：Wehavepreviouslydevelopedacombinedsignal/variancedistributionmodelthataccountsfortheparticularstatisticalpropertiesofdatasetsgeneratedontheAp-pliedBiosystemsAB1700transcriptomesystem.Hereweshowthatthismodelcanbeefficientlyusedtogeneratesyntheticdatasetswithstatisticalpropertiesvirtu-allyidenticaltothoseoftheactualdatabyaidoftheJAVAapplicationace.mapcreator1.0thatwehavedeveloped.ThefundamentallydifferentstructureofAB1700transcriptomeprofilesrequiresre-evaluation,adaptation,orevenrede-velopmentofmanyofthestandardmicroarrayanalysismethodsinordertoavoidmisinterpretationofthedataontheonehand,andtodrawfullbenefitfromtheirincreasedspecificityandsensitivityontheotherhand.Ourcompositedatamodelandtheace.mapcreator1.0applicationtherebynotonlypresentproofofthecor-rectnessofourparameterestimation,butalsoprovideatoolforthegenerationofsynthetictestdatathatwillbeusefulforfurtherdevelopmentandtestingofanalysismethods.

简介：Inthisreview,weadvanceanewconceptindevelopingvaccinesand/ordrugstotargetspecificproteinsexpressedduringtheearlystageofBacillusanthracis(anthrax)infectionandaddressexistingchallengestothisconcept.Threeproteins(immuneinhibitorA,GPR-likesporeprotease,andalanineracemase)initiallyidentifiedbyproteomicsinourlaboratorywerefoundtohavedifferentialexpressionsduringanthraxsporegerminationandearlyoutgrowth.Otherstudiesofdifferentbacillusstrainsindicatethatthesethreeproteinsareinvolvedineithergerminationorcytotoxicityofspores,suggestingthattheymayserveaspotentialtargetsforthedesignofanti-anthraxvaccinesanddrugs.

简介：人的造血作用用控制干细胞区别的技术被评估，二维的胶化基于电气泳动的proteomics，和功能的基因组学。我们提供神经胶质成熟因素鲸鱼群妈(GMFG)是cytokine应答的蛋白质在的第一份报告导致erythropoietin并且刺激导致因素的造血的系开发的granulocyte殖民地。从全球功能的基因组学分析的结果显示GMFG拥有几个另外的特征：造血的织物特定的基因表示，与高分数的造血作用特定的抄写因素集中的一个倡导者，和有一个原始血/免疫者系统的可能的分子的coevolution。根据我们的调查结果，我们假设那GMFG是可以调停的造血特定的蛋白质人的造血的干细胞的pluripotentiality和系承诺。