简介：Systemictoxicityandinsufficientdrugaccumulationatthetumours让earemainbarriersinchemotherapy.Thermosens让iveliposomes(TSL)combinedwithhighintensityfocusedultrasound(HIFU)hasemergedasapotentialsolutiontoovercomethesebarriersthroughtargeteddrugdeliveryandlocalisedrelease.Owingtothemultiplephysicalandbiochemicalprocessesinvolvedinthiscombinationtherapy,mathematicalmodellingbecomesanindispensabletoolfordetailedanalysisofthetransportprocessesandpredictionoftumourdruguptake.Tothisend,amultiphysicsmodelhasbeendevelopedtosimulatethetransportofchemotherapydrugsdeliveredthroughacombinedHIFU-TSLsystem.Allkeydeliveryprocessesareconsideredinthemodel;theseineludeinterstitialfluidflow,HIFUacoustics,bioheattransfer;drugreleaseandtransport,aswellastumourdruguptake.Thecapabilityofthemodelisdemonstratedthroughitsapplicationtoa2-Dprostatetumourmodelreconstructedfrommagneticresonanceimages.Ourresultsnotonlydemonstratethefeasibilityofthemodeltosimulatethiscombinationtherapy,butalsoconfirmtheadvantageofHIFU-TSLdrugdeliverysystemwithenhancementofdrugaccumulationintumourregionsandreductionofdrugavailabilityinnormaltissue.ThismultiphysicsmodellingframeworkcanserveasausefultooltoassistinthedesignofHIFU-TSLdrugdeliverysystemsandtreatmentregimenforimprovedanticancerefficacy.