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简介：CellResearchispublishedmonthlybyNaturePublishingGroupinpartnershipwithShanghaiInstitutesforBiologicalSciences(SIBS),ChineseAcademyofSciences(CAS).CellResearch,whichpublishesexclusivelyinEnglish,isChina'sleadingjournalinthelifescienceswithacurrentImpactFactorof3.426(Thomson-ISI,PA,USA2007).Thejournalisindexed/abstractedinIndexMedicus/Medline/PubMed,ScienceCitationlndex,CurrentContents-lifeSciences,SciSearchandISIWebofScience,ChemistryAbstracts,BIOSIS,VINITI,Cbinainfo(CD&Web),CJFD(CD&Web),CJCDandCEPS,etc.ScopeCellResearchisaninternationaljournalpublishingpeer-reviewedoriginalarticles,invitedreviews,commentaries,andshortcommunications.Thejournalhasaninternationalauthorshipandabroadscopeinbasicresearchofcellbiology,molecularcellbiology,includingcellgrowthanddifferentia-tion,signaltransduction,apoptosis,stemcells,development,immunology,neurosciences,plantcellbiology,chromatinmodulation,epigeneticsandtranscription.EditorialManuscriptsshouldbesubmittedonlineathttp://www.nature.com/crorhttp://www.cell-research.com.Howeverifyouhaveproblems,pleasecontactEditorialOfficeatcellres@sibs.ac.cn.DetailedInstructionsforAuthorsarealsoavailableattheabovewebsites.PublisherExceptforcompaniesbasedinmainlandChina,allbusinesscorrespondenceandenquiriesaboutsupplementpublication,sponsorshipopportunitiesandadvertisingshouldbeaddressedtoNaturePublishingGroup(NPG).NickCampbell,AssociatePublisher,ExecutiveEditor:NPGNatureAsia-Pacific,MacmillanPublishers,LockedBag1,PrahranVIC3181,Australia.Tel:+61(0)398251028;Fax:+61(0)398251010.E-mail:n.campbell@natureasia.com

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简介：SARSResearchinChina

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简介：Stemcellspossesstheremarkableabilityofextensiveself-renewalanddifferentiationintospecificcelllineages,andtheyplayessentialrolesindevelopmentandadulttissuehomeostasis.Duetotheircriticalimportanceinnormalphysiologyandthepromiseforuseinregenerativemedicinetotreatavarietyofdiseases,stemcellshaveattractedextensiveresearchinterestinrecentyears.AsChina'spremiumin-ternationaljournalwithabroadscopeincellandmolecularbiology,CellResearchhaswitnessedmoreandmoresubmissionsonstemcellresearch.Indeed,alongwiththetraditionalstrengthsofthejournalinmolecularimmunology,cancerbiology,andplantmolecularphysiology,stemcellresearchhasgraduallyandnaturallyevolvedintoanewgrowthpointofCellResearch.Reflectingthegrowinginterestofbothourreadersandauthorsinthisexcitingandexpandingfield,wearepleasedtopresentthisSpecialIssueonStemCellResearch.

简介：ProteomicshasbeenwidelyusedinthelastfewyearstolookfornewbiomarkersanddecipherthemechanismofHIV-hostinteraction.Herein,wereviewtherecentdevelopmentsofHIV/AIDSproteomicresearch,includingthesamplesusedinHIV/AIDSrelatedresearch,thetechnologiesusedforproteomicstudy,thediagnosisbiomarkersofHIV-associateddiseaseespeciallyHIV-associatedneurocognitiveimpairment,themechanismsofHIV-hostinteraction,HIV-associateddementia,substanceabuse,andsoon.Intheendofthisreview,wealsogivesomeprospectsaboutthelimitationandfutureimprovementofHIV/AIDSproteomicresearch.

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简介：Fishesarefamousfortheirabilitytopositionthemselvesaccuratelyeveninturbulentflows.Thisabilityistheresultofthecoordinatedmovementoffinswhichextendfromthebody.Wehaveembarkedonaresearchprogramdesignedtodevelopanagileandhighefficientbiologicallyinspiredroboticfishbasedontheperformanceofhybridmechanicalfins.Toaccomplishthisgoal,amechanicalray-likefinactuatedbyShapeMemoryAlloy(SMA)isdeveloped,whichcanrealizebothoscillatorylocomotionandundulatorylocomotion.Wefirstgiveabriefintroductiononthemechanicalstructureofourfinandthencarryouttheoreticanalysisonforcegeneration.DetailedinformationofthesetheoreticalresultsislaterrevealedbyComputationalFluidDynamic(CFD),andisfinalvalidatedbyexperiments.Thisroboticfinhaspotentialapplicationasapropulsorforfutureunderwatervehiclesinadditiontobeingavaluablescientificinstrument.

简介：Inthispaper,acarangiformroboticfishwith4-DoF(degreeoffreedom)tailhasbeendeveloped.Theroboticfishhascapabilityofswimmingundertwomodesthatareradiocontrolandautonomousswimming.Experimentswereconductedtoinvestigatetheinfluencesofcharacteristicparametersincludingthefrequency,theamplitude,thewavelength,thephasedif-ferenceandthecoefficientonforwardvelocity.Theexperimentalresultsshownthattheswimmingperformanceoftheroboticfishisaffectedmostlybythecharacteristicparametersobserved.

简介：Biomimeticdesignemploystheprinciplesofnaturetosolveengineeringproblems.Suchdesignswhicharehopedtobequick,efficient,robust,andversatile,havetakenadvantageofoptimizationvianaturalselection.Inthepresentresearch,anenvironment-friendlypropulsionsystemmimickingundulatingfinsofstingraywasbuilt.Anon-conventionalmethodwasconsideredtomodeltheflexibilityofthefinsofstingray.Atwo-degree-of-freedommechanismcomprisedofseverallinkageswasdesignedandconstructedtomimictheactualflexiblefin.Thedrivinglinkageswereusedtoformamechanicalfincon-sistingofseveralfinsegments,whichareabletoproduceundulations,similartothoseproducedbytheactualfins.Owingtothemodularityofthedesignofthemechanicalfin,variousundulatingpatternscanberealized.Somequalitativeobservations,obtainedbyexperiments,predictedthatthethrustsproducedbythemechanicalfinaredifferentamongvariousundulatingpatterns.Tofullyunderstandthisexperimentalphenomenonisveryimportantforbetterperformanceandenergysavingforourbioroboticunderwaterpropulsionsystem.Here,fourbasicundulatingpatternsofthemechanicalfinwereperformedusingtwo-dimensionalunsteadycomputationalfluiddynamics(CFD)method.Anunstructured,grid-based,unsteadyNavier-Stokessolverwithautomaticadaptivere-meshingwasusedtocomputetheunsteadyflowaroundthefinthroughtwentycompletecycles.Thepressuredistributiononfinsurfacewascomputedandintegratedtoprovidefinforceswhichweredecomposedintoliftandthrust.Thepressureforceandfrictionforcewerealsocomputedthroughouttheswimmingcycle.Finally,vortexcontourmapsofthesefourbasicfinundulatingpatternsweredisplayedandcompared.

简介：Thedisadvantagescausedbytheswingofafishbodywereanalyzed.Thecoordinatesystemofatwo-jointrobotfishwasbuilt.Thehydrodynamicanalysisofrobotfishwasdeveloped.Thedynamicsimulationofatwo-jointrobotfishwascarriedoutwiththeADAMSsoftware.Therelationshipbetweentheswingoffishbodyandthemassdistributionofrobotfish,therela-tionshipbetweentheswingoffishbodyandtheswingfrequencyoftail,weregained.Theimpactoftheswingoffishbodyonthekinematicparametersoftailfinwasanalyzed.Threemethodstorestraintheswingoffishbodywerepresentedanddis-cussed.

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