简介：Coronaryangiographyaftercardiacarrestisimportanttoascertainpotentialtreatablecausesofcardiacarrest,salvagemyocardium,andpotentiallyincreaselong-termsurvival.Thecauseofadultout-of-hospitalcardiacarrestistypicallymyocardialischemia.Morethan50%ofsuchresuscitatedindividualswillhaveanacutelyoccludedepicardialcoronaryonemergencycoronaryangiography.ThisincludesthreeinfourwithST-segmentelevationandoneinthreewithoutSTsegmentelevation.Inthelattertheonlyreliablemethodofdetectioniscoronaryangiography.Numerouscohortstudies,nowincludingmorethan8000patients,haveshownanassociationbetweensurvivalandearlycoronaryangiographyand/orpercutaneouscoronaryintervention.Publicreportingofpercutaneouscoronaryintervention30-daymortalityrateshasbeenanimpedimentforextendingthistherapytoallresuscitatedindividualswhoexperiencedout-of-hospitalcardiacarrest,sincecurrentdatabasestodofullyrisk-adjustratesforthissubgroup.Sincereeffortsareunderwaytocorrectthissituation.

简介：Bydifferentiatingfourdifferenttypesofoutput,thepaperarguesthattheirrolesarealsodifferent.Andlearnersofdiffer-entlanguageproficiencylevelsshouldbeguidedtoproducedif-ferenttypesofoutput.Thusthepaperintroducesanewconcept,namely"optimaloutput".BlindlymakingthelearnerproduceoutputwhichisfarbeyondhiscurrentEnglishlevelwillonlydoharmtohisinterlanguagedevelopment,makingitfossilizeatanearlystage.

简介：在这篇论文，当仅仅输出为反馈是可得到的时，追踪控制的输出为非线性的系统的一个类被调查。基于圆标准的多可变的类似物，一个观察员首先被介绍。然后，追踪控制器的基于观察员的产量被使用积分回来积极地设计和完成平方走途径。在相对温和的条件下面，所有靠近环的信号一致地被围住，这被显示出。同时，系统产量asymptotically追踪需要的产量。Asimulation例子被给说明理论结果的有效性。

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简介：AbstractBackground:Super-responders (SRs) to cardiac resynchronization therapy (CRT) regain near-normal or normal cardiac function. The extent of cardiac synchrony of SRs and whether continuous biventricular (BIV) pacing is needed remain unknown. The aim of this study was to evaluate the cardiac electrical and mechanical synchrony of SRs.Methods:We retrospectively analyzed CRT recipients between 2008 and 2016 in 2 centers to identify SRs, whose left ventricular (LV) ejection fraction was increased to ≥50% at follow-up. Cardiac synchrony was evaluated in intrinsic and BIV-paced rhythms. Electrical synchrony was estimated by QRS duration and LV mechanical synchrony by single-photon emission computed tomography myocardial perfusion imaging.Results:Seventeen SRs were included with LV ejection fraction increased from 33.0 ± 4.6% to 59.3 ± 6.3%. The intrinsic QRS duration after super-response was 148.8 ± 30.0 ms, significantly shorter than baseline (174.8 ± 11.9 ms, P = 0.004, t = -3.379) but longer than BIV-paced level (135.5 ± 16.7 ms, P = 0.042, t = 2.211). Intrinsic LV mechanical synchrony significantly improved after super-response (phase standard deviation [PSD], 51.1 ± 16.5° vs. 19.8 ± 8.1°, P < 0.001, t= 5.726; phase histogram bandwidth (PHB), 171.7 ± 64.2° vs. 60.5 ± 22.9°, P < 0.001, t= 5.376) but was inferior to BIV-paced synchrony (PSD, 19.8 ± 8.1° vs. 15.2 ± 6.4°, P = 0.005, t = 3.414; PHB, 60.5 ± 22.9° vs. 46.0 ± 16.3°, P = 0.009, t = 3.136).Conclusions:SRs had significant improvements in cardiac electrical and LV mechanical synchrony. Since intrinsic synchrony of SRs was still inferior to BIV-paced rhythm, continued BIV pacing is needed to maintain longstanding and synchronized contraction.

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简介：NICFEDexpertsystem-arule-based"non-invasivecardiacfunctionevaluationandcardiacdiseasesdiagnosingexpertsystem"-isdiscussedinthispaper.Thesys-temcanberegardedasaninterpretationexpertsystemandasadiagnosticexpertsystem.Whenitisappliedtoevaluatecardiacfunction,itcanexplainmorethanonehundredparametersdetectedby"MCA-Ⅲcardiacfunctiondeviceofmulti-domainandmultidemension".Withtheseparametersthecardiacfunctionintimedomain,fre-

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简介：Positronemissiontomography(PET)isapowerfulnoninvasiveimagingtoolforphenotypingpatientsatriskoforwithknowncoronaryarterydisease(CAD).Oneofthekeyadvantagesoverotherimagingmodalitiesisitsuniqueabilitytoquantifyphysiologicprocesses,includingmyocardialbloodflow(inmillilitersperminutepergramofmyocardium),metabolism,andcardiacreceptors,anditshighsensitivityfordelineatingandquantifyingmoleculartargetsinvivousingtargetedimagingprobes.CardiacPET/CToffersopportunityforacomprehensivenoninvasiveevaluationoftheconsequencesofatherosclerosisinthecoronaryarteriesandthemyocardium.

简介：ObjectivesToevaluateretrospectivelythepotentialbenefitsofcombinedutilizationofvariousassistedcirculationdevicesincardiacarrestpatientswhodidnotrespondtoconventionalcardiopulmonarycerebralresuscitation(CPCR).MethodsAssistedcirculationdevices,includingemergencycardiopulmonarybypass(ECPB),intra-aorticballoonpump(IABP),andleftventricularassistdevice(LVAD),wereappliedto16adultpatientswhohadcardiacarrest82min-56hafteropenheartsurgeryanddidnotrespondto20minorlongerconventionalCPCR.ECPBwasappliedto2patients,ECPBplusIABPto8patients,ECPBplusIABPandLVADto6patients.ResultsOnepatientrecoveredfullyandonepatientdied.Oftheother14patients,13resumedspontaneouscardiacrhythmandonedidnot;noneofthemcouldbeweanedfromECPB.Furthertreatmentofthe14patientswithcombinationsofassistedcirculationdevicesenabled6patientstorecover.Oneofthe7recoveredpatientsdiedofreoccurringcardiacarrestafter11days;theother6weredischargedingoodconditionandwerefollowedupfor3-49months(mean=22months).Ofthe6dischargedpatientsonesufferedcerebralembolismduringLVADtreatment,resultinginmildlimitationofmobilityoftherightlimbs;theother5nevermanifestedanycentralnervoussystemcomplications.Therewasnolatedeathsgivinga37.5%(6/16)long-termsurvivalrate.ConclusionsECPBcouldeffectivelyreestablishbloodcirculationandoxygensupply,rectifyacidosis,andimproveinternalmilieu.ThecombinedutilizationofECPB,IABP,andLVADreducesthedurationofECPB,improvestheincidenceofrecovery,andoffersbeneficialalternativestorefractorycardiacarrestpatients.

简介：BackgroundThevideo-assistedthoracoscopicsurgicaltechniquesarewidelyusedinthetreatmentofpatientswithcongenitalheartdiseaseswithgoodoutcomes.However,thefeasibilityandsignificanceofnursebasedearlycardiacrehabilitationincardiacintensivecareunit(ICU)forpatientswithtotallythoracoscopiccardiacoperationhasbeenseldomstudied.MethodsThirty-sixpatientswithtotallythoracoscopiccardiacoperationundertheconditionofthecardiacICUinGuangdongGeneralHospitalwererandomallocatedtotheinterventiongroupandthecontrolgroupbetweenJanuary2012toDecember2014.Thecontrolgroupreceivedstandardnursingcare,andtheinterventiongroupreceivedearlycardiacrehabilitationnursingcareinadditiontostandardcare.Theoutcomemeasuresincludedtheoxygensaturation(SpO2%),vitalcapacity,forcedexpiratoryvolumein1second(FEV1),andpaininthethoracicwound(visualanaloguescale,VAS),whichweremeasuredatthebaselineandwithin2-dayafter4-weeknursingcare.Forsafetyreason,wealsomonitoredtherateofperceivedexertion(RPE),heartrate,systemicbloodpressure.ResultsTherewerenon-significantdifferencesbetweenthegroupsinage,sex,totalnumberofcomorbidconditions,totalnumberofmedications,surgicaltime,andanesthetictime(P>0.05).Following4weekstreatment,thecardiopulmonaryfunctionsandVASscorewereimproved(P<0.05)inallgroups.Inaddition,theimprovementsweremoreintheearlycardiacrehabilitationnursecaregroupthaninthecontrolgroup(P<0.05).ConclusionTheearlycardiacrehabilitationnursingcareincardiacICUissafe,feasibleandbeneficialforpatientswithtotallythoracoscopiccardiacoperation.

简介：CASEREPORTA43-year-oldChinesemalefarmerpresentedtothehospitalwithcomplaintsofexertionalpalpitationanddyspneafor2months.Hehadhisdiscomfortsoftentogetherwithdrycough,andgraduallyappearedparoxys-

简介：Theconnexin43(Cx43)proteins,whichisthepredominantproteinthatcanformgapjunctionsandnon-junctionalhemichannelsinventricularmyocardium,arecentraltothecardioprotectionaffordedbyischemicpreconditioning(IP)andmaybeischemicpostconditioning(PC)too.RecentstudiesshowedthatrecruitmentofCx43tothemitochondriainIPmightplayaroleintheproductionofreactiveoxygenspecies(ROS)thatmediatesIP.ThelocalizationofCx43atmitochondriaappearstobeimportantfortheachievedcardioprotectionandopensanewdoorforustorevealtheexactmechanismsofischemia/reperfusion(I/R)injuryandcardioprotection,anditmightbenewtargetsofpharmacologicalmodulatortoachievedcardioprotection.

简介：在心肌层的重入的推动被认为是支持electrophysiological畸形或甚至导致室的心悸亢进(vt)和室的纤维性颤动(VF)的一个主要因素。重入的波浪的尖端轨道能反映重入的运动的电的繁殖和区域的稳定性，从而在在VT/VF期间学习电的活动被看作大多数担心的参数之一。现在的学习的目的是建议一个实际方法用一条计算途径发现尖端轨道。在室的房间的这个学习Luo-Rudy1991数学模型被使用。切开方法的操作员被利用在二维的织物集成部分微分方程。并且螺线波浪被切割波浪前面技术开始。通过我们发现了它的实验是困难的由发现在大多数报纸求婚了的二根isovoltage线的交叉发现尖端。因此，我们建议尖端点被寻求二根邻近的isovoltage轮廓线的最短的距离检测。结果证明以我们的方法发现的这些螺线波浪的尖端轨道很接近观察的尖端，暗示我们在测量在心脏的再废的尖端轨道的方法的确认。

简介：Thetechniqueofcomputersimulationsisaveryefficientmethodininvestigatingmechanismsofmanydiseases.Thispaperreviewshowthesimulationsofthehumanheartstartedasasimplemathematicalmodelsinthepastanddevelopedtothepointwheregeneticinformationisneededtodosuitableworklikefindingoutnewmedicamentsagainstheartdiseases.AlsotheInfluenceofthedevelopmentofcomputerperformanceinthefutureaswellasthedatapresentationisdescribed.

简介：Inthelastseveralyears,therateofinnovationincardiacimagingtechniqueshasacceleratedsignificantly.Advanceshavebeenseeninall4majormodalities;echocardiography,nuclear(positronemissiontomography(PET)andsinglephotonemissioncomputedtomography(SPECT),cardiacmagneticresonanceimaging(CMR),andcomputedtomographicangiography(CTA).ThisissueofCardiovascularInnovationsandApplicationswillhighlightmanyoftheseadvances.

简介：RecentstudiesrevealingtheimportantrolesofmicroRNAs（miRNAs）inregulatingexpressionofionchannelgeneshaveopeneduparesearchfieldforextendinganddeepeningourinvesti-gationintothecardiacexcitabilityandtheassociatedarrhythmogenesis.Cardiacexcitability,thefundamentalpropertyofthecardiacmyocytes,definesthecardiacconduction,repolarization,automaticity,intracellularcalciumhandling,andtheirregionalheterogeneity.OurpreviousandongoingstudiesandtheworkfromotherlaboratorieshavedemonstratedthesignificantinvolvementofmiRNAsinregulatingeveryaspectsofcardiacexcitability.Wehavefoundearlierthatthemuscle-specificmiRNAmiR-1boostsupthearrhythmogenicpotentialthroughtargetinggapjunctionchannelconnexin43inmyocardialinfarction.AsubsequentstudyrevealedthatmiR-1canalsocausearrhythmiasbyimpairingCa2+handlingbytargetingphosphatase.Wethenidentifiedanothermuscle-specificmiRNAmiR-133promotesabnormalQTprolongationbyrepressingHERGK+channelexpressionindiabeticcardiomyopathy.Subsequently,wediscoveredthatbothmiR-1andmiR-133areinvolvedinthereexpressionofpacemakerchannelsHCN2/HCN4toenhanceabnormalautomaticityincardiachypertrophy.Recently,wefurtheridentifiedmiR-328asanimportantdeterminantforatrialfibrillation（AF）andtheassociatedadverseatrialelectricalremodelingviatargetingL-typeCa2+channels.Whilealltheabove-mentionedmiRNAsareproarrhythmic,wehavenewlyidentifiedforthefirsttimeanaturalantiarrhythmicmiRNAmiR-26.WefoundthatallthreemembersofthemiR-26familyisdownregulatedintheirexpressioninAFtissuesandthisdownregulationincreasesAFvulnerabilityasaresultofremovalofanendogenousantiarrhythmicfactor.miR-26downregulationshortensatrialactionpotentialfavoringAFbyincreasinginwardrectifierK+current（IK1）density.ThisiscausedbyanupregulationofKir2.1K+channelsu

简介：Inanerawhencardiactransplantpatientsaresurvivingmoreimmediateissuesofrejectionandinfection,theprevalenceofmorechronicissuessuchascardiacallograftvasculopathy(CAV)isrising.Thiscasedescribesaman20yearsaftercardiactransplantwithhisfirstpresentationofCAV.Acutemyocardialinfarctionwasdiagnosedonthebasisofsymptomsandbiochemicalmarkersandoncoronaryangiography,andhewasfoundtohaveacriticalstenosisofthemidportionoftheleftanteriordescendingartery.Itwaselectedtotreatthispercutaneouslywithafullybioresorbablevascularscaffold(BVS)becauseofthediffusenatureofthediseaseprocess.Thiswassuccessfullyperformedwithopticalcoherencetomographyguidance.TheuseofBVSinCAVhasnotbeenwellstudied.ThisisoneoffewcasereportsdescribingtheuseofBVSinCAV.

简介：这份报纸学习在一个空间领域上演变的一个分布式的双线性的系统的地区性的稳定。为地区性的弱、强壮、指数的稳定的足够的条件被给。另外，我们讨论一个地区性的最佳的稳定问题。获得的结果被例子和模拟说明。

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