简介：BackgroundDeepsternawoundinfection(DSWI)aftermediansternotomyforcardiacsurgeryisoneofthemostcomplexandpotentiallylife-threateningcomplications.ItsverydifficulttotreatDSWI,andthereislackofagreementregardingthebesttherapystrategy.Thus,weaimedtosummarizeourexperiencesofsurgicaltreatmentforDSWI,inwhichsatisfactoryclinicalresultswereobtained.MethodsWeretrospectivelyanalyzed17caseswhosufferedfromDSWIaftercardiacsurgeryinourdepartmentfromJanuary2010toJune2015.Therewere8maleand9femalepatientswiththeiraverageageof62.7±9.5years(range42~75years).Allpatientsreceivedreservationofpartofsternumcombinedwithvacuum-assistedsuctiondrainageandbilateralpectoralismajormyocutaneousadvancementflaps.ResultsTheaverageintervalbetweencardiacsurgeryanddiagnosedDSWIwas10.9±6.5days(range5~21days).Timeofvacuum-assistedsuctiondrainagewas11.6±4.8days(range5~15days)andwoundhealingtimewas27.3±7.2days(range23~35days).Allpatientshadanuneventfulpostoperativerecoveryandgoodwoundhealing.Follow-uptimewas33.7±13.3months(range8~74months).Norecurrentinfectionwasobserved.ConclusionsReservationofpartofsternumcombinedwithvacuum-assistedsuctiondrainageandbilateralpectoralismajormyocutaneousadvancementflapsisasimpleandeffectivesurgicalstrategyforthetreatmentofDSWIaftercardiacsurgery.

简介：摘要ObjectiveTo investigate a 5-generation Chinese Han family with PRKAG2 cardiac syndrome resulting from mutations in the PRKAG2 gene encoding the AMP-activated protein kinase (AMPK) gamma 2 subunit and the treatment of myocardial hypertrophy in patients with PRKAG2 cardiac syndrome.MethodIn this study, a 5-generation Chinese Han family (n = 40) with complete atrioventricular block and asymmetric interventricular septal hypertrophy was taken as the research object, and the DNA were obtained from 30 of them (6 patients and 24 normal persons). Objective gene capture combined with high-throughput sequencing technique was used to detect the genes of family members. After the gene diagnosis was confirmed, the cardiac data of patients taking beta-blockers in this family were analyzed retrospectively with the average annual increase in thickness of interventricular septum (expressed in mm/year) as an index.ResultsA total of 6 family members were associated with PRKAG2 (c.905G>A; pR302Q) heterozygous variation. The phenotype of pedigree patients is characterized by complete atrioventricular block and asymmetric interventricular septal hypertrophy, which has high homogeneity. No syncope occurs after implantation of permanent pacemaker, but atrial flutter and atrial fibrillation occur. The 5 patients with PRKAG2 cardiac syndrome in the family took beta-blockers for a long time, and the progress of cardiac hypertrophy was significantly delayed.ConclusionsOur results suggest that the possibility of PRKAG2 mutations should be considered in patients with complete atrioventricular block and asymmetric interventricular septal hypertrophy, and that prompt implantation of pacemakers and long-term use of beta blockers may improve the prognosis of PRKAG2 cardiac syndrome patients.

简介：无

简介：Cardiologistswhoseepatientsonageneralcardiologyservicearebeginningtoseeanincreasingnumberofpatientswhohavereceivedaprimarypreventionimplantablecardiacdefibrillator(ICD)buthaveneverhaditfire.ThereareadditionallyanumberofpatientswhohaveinappropriatefiringofICDs.Inappropriateshocksoccurinupto40%ofpatientswithanICD.Themaincauseissupraventriculartachyarrhythmia,includingsinustachycardia,atrialfibrillation,andotherrapidsupraventriculararrhythmias.

简介：

简介：ObjectivesToexploretheeffectoflosartanoncardiacandrenalfunctioninpatientswithchronicheartfailure(CHF).MethodsSixty-fivepatientswithCHFweredividedintotwogroupsusingarandomized,controlandsingleblindmethod:losartangroup(n=30)andconventiongroup(n=35),withatreatmentcourseof8weeksforbothgroups.TheconcentrationsofcystatinC(cysC)inserum,microamountalbumin(MA)inurineweremeasuredbyimmunoturbidimetry.Theconcentrationofaquaporin-2(AQP-2)wasdeterminedbyenzyme-linked-immunosorbentassay(ELISA)andtheheartcontractilefunctionwasmeasuredbyechocardiographybeforeandaftertreatmentrespectively.ResultsComparingwithroutinetreatmentgroup,leftventricularend-diastolicdimension(LVEDd)decreasedsignificantly,whileleftventricularejectionfraction(LVEF)andleftventricularfractionalshortening(LVFS)increasedsignificantlyinlosartangroup.ThelevelsofcysCinserumandMA,AQP-2inurineweresignificantlylowerinlosartangroupthaninroutinetreatmentgroup.ConclusionLosartancanimprovecardiacandrenalfunctioninpatientswithCHF.

简介：

简介：Thesympatheticnervoussystemplaysacardinalroleinregulatingcardiacfunctionthroughreleasingtheneurotransmitternorepinephrine(NE).Incomparisonwithcentralnervoussystem,themolecularmechanismofNEuptakeinmyocardiumisnotclear.Inpresentstudy,weprovedthatinrattheCNStypeofNEtransporter(NET)wasalsoexpressedinmiddlecervical-stellateganglioncomplex(MC-SGcomplex)whichisconsideredtocontroltheactivityofheart,butnotexpressedinmyocardium.TheresultsalsoshowedthatNETexpressionlevelinrightganglionwassignificantlyhigherthanintheleft,renderingthegreatercapacityofNEuptakeinrightventricle,afactwhichmaycontributetothemaintenanceofrightventricularfunctionunderpathologicstate.

简介：

简介：

简介：

简介：WeinvestigatetheexponentialstabilityinthemeansquaresenseforthesystemswithMarkovianswitchingandimpulseeffects.BasedonthestatisticpropertyoftheMarkovprocess,astabilitycriterionisestablished.Then,bytheparameterizationsviaafamilyofauxiliarymatrices,thedynamicaloutputfeedbackcontrollercanbesolvedviaanLMIapproach,whichmakestheclosed-loopsystemexponentiallystable.Anumericalexampleisgiventodemonstratethemethod.

简介：为有未知结构的非线性的系统的一个系统鉴定方法用短输入产量数据被介绍。方法简化原来的NARMAX方法。它为非线性的系统介绍更一般的模型结构。方法被采用获得模型术语的数据处理的组方法(GMDH)；参数。建议方法的有效性被一个典型非线性的系统与未知结构说明；缺乏的输入产量数据。

简介：

简介：为基于与转换相结合的单个不安理论，设计为非仿射的非线性的系统的一个类被考虑的输出规定的一个控制合成方法。产生控制信号被定义为转换的“快”的动力学的一个答案一个系列错误模型，其状态指数地稳定。在与单个不安理论的假设一致的足够的条件下面，这个问题是可解决的与，这被显示出(ɛ)如果并且仅当一套一阶的非线性的部分微分方程是可解决的，追踪错误。控制法律能容易被构造，模拟显示出控制器的可行性和有效性。

简介：InATMnetworks,burstysourcescanbedescribedastheInterruptedBernoulliProcess(IBP).Withtheuseofthethinprocesstheory,theProbabilityGeneratingFunction(PGF)oftheIBPisobtained.Aniterativealgorithm,whichcanbeusedtocalculatetheIBPprobabilitydistribution,ispresented.Theburstysource’sequivalentdescriptionisdiscussed.ItisproposedthattheleakybucketoutputprocesscanbeapproximatelydescribedastheIBP.Theaccuracyoftheanalyticalresultshasbeenlargelyvalidatedbymeansofthesimulationapproach.Moreover,howtoimproveitsaccuracyisdiscussed.Thesmoothingfunctionoftheleakybucketalgorithmisquantitativelyanalyzed.

简介：一个建设性的方法被介绍为在波浪，风，和海洋水流导致的环境骚乱下面的表面轮船的动态放设计一个全球柔韧、适应的产量反馈控制器。轮船参数没被要求被知道。一个适应观察员首先被设计估计轮船速度和参数。轮船位置大小也被通过从进入控制系统减少高频率测量噪音的适应观察员。用这些估计信号，控制然后基于Lyapunovs直接方法被设计强迫轮船位置和取向到asymptotically全球性收敛到需要的值。模拟结果说明建议控制系统的有效性。在结论，纸论述了一个新方法为表面轮船的动态放设计一个有效控制系统。

简介：细菌和植物可将二氧化碳转化为更有用的化合物，但人类仍在努力通过实践实现这一挑战。现在，面对这一方向开发的催化系统，以高的周转率使CO2还原为CO已迈出新的一步。

简介：无

简介：评估由于长期的心脏的失败为浮肿与中国植物粘住的acupoint的治疗学的效果。