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简介：关于为心脏性的吃惊的处理的levosimendan的使用的编辑的一封信被介绍。

简介：Wehavereviewedthegenetherapyingastrointestinaldiseases^[1].GastriccanceriscommoninChina^(2-20),anditsearlydiagnosisandtreatmentarestilldifficultuptonow^(13-36).Theex-pressionofanexogenousgeneintroducedbygenetherapyintopa-tientswithgliomascanbemonitorednon-invasivelybypositron-emissiontornography^[4].

简介：AbstractGastric cancer (GC) is a common malignancy and is the third leading cause of cancer-related death. At present, there is no simple and effective screening method for early-stage GC, and the treatment results and prognosis are poor. With the continuous improvement of molecular biology techniques, research on circular RNA (circRNA) has gradually expanded over time. Much data supports the role of circRNA in tumorigenesis. Moreover, due to its structural specificity and biological stability, circRNA is anticipated to be a potential biomarker for tumor diagnosis. Studies have confirmed that circRNA can participate in the proliferation, invasion, metastasis, and apoptosis of GC. These findings will lead to novel directions for the diagnosis and treatment of GC. This article reviews the structure and function of circRNA, summarizes the current studies on circRNA, and discusses the potential diagnostic value of circRNA in GC.

简介：AbstractBackground:With the wide application of endoscopic submucosal dissection (ESD) for early gastric neoplasms, metachronous gastric neoplasms (MGN) have gradually become a concern. This study aimed to analyze the characteristics of MGN and evaluate the treatment and follow-up outcomes of MGN patients.Methods:A total of 814 patients were retrospectively enrolled. All these patients were treated by ESD for early gastric cancer or gastric dysplasia between November 2006 and September 2019 at The First Medical Center of Chinese People’s Liberation Army General Hospital. The risk factors for MGN were analyzed using Cox hazard proportional model. Moreover, the cumulative incidence, the correlation of initial lesions and MGN lesions, and the treatment and follow-up outcomes of MGN patients were analyzed.Results:A total of 4.5% (37/814) of patients had MGN after curative ESD. The 3-, 5-, and 7-year cumulative incidences of MGN were 3.5%, 5.1%, and 6.9%, respectively, and ultimately reaching a plateau of 11.3% at 99 months after ESD. There was no significant correlation between initial lesions and MGN lesions in terms of gross type (P = 0.178), location (long axis: P = 0.470; short axis: P = 0.125), and histological type (P = 0.832). Cox multivariable analysis found that initial multiplicity was the only independent risk factor of MGN (hazard ratio: 4.3, 95% confidence interval: 2.0-9.4, P < 0.001). Seventy-three percent of patients with MGN were treated by endoscopic resection. During follow-up, two patients with MGN died of gastric cancer with lymph node metastasis. The disease-specific survival rate was significantly lower in patients with MGN than that in patients without MGN (94.6% vs. 99.6%, P = 0.006).Conclusions:The MGN rate gradually increased with follow-up time within 99 months after curative gastric ESD. Thus, regular and long-term surveillance endoscopy may be helpful, especially for patients with initial multiple neoplasms.

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简介：AbstractBackground:Texture analysis (TA) can quantify intra-tumor heterogeneity using standard medical images. The present study aimed to assess the application of positron emission tomography (PET) TA in the differential diagnosis of gastric cancer and gastric lymphoma.Methods:The pre-treatment PET images of 79 patients (45 gastric cancer, 34 gastric lymphoma) between January 2013 and February 2018 were retrospectively reviewed. Standard uptake values (SUVs), first-order texture features, and second-order texture features of the grey-level co-occurrence matrix (GLCM) were analyzed. The differences in features among different groups were analyzed by the two-way Mann-Whitney test, and receiver operating characteristic (ROC) analysis was used to estimate the diagnostic efficacy.Results:InertiaGLCM was significantly lower in gastric cancer than that in gastric lymphoma (4975.61 vs. 11,425.30, z = -3.238, P = 0.001), and it was found to be the most discriminating texture feature in differentiating gastric lymphoma and gastric cancer. The area under the curve (AUC) of inertiaGLCM was higher than the AUCs of SUVmax and SUVmean (0.714 vs. 0.649 and 0.666, respectively). SUVmax and SUVmean were significantly lower in low-grade gastric lymphoma than those in high grade gastric lymphoma (3.30 vs. 11.80, 2.40 vs. 7.50, z = -2.792 and -3.007, P = 0.005 and 0.003, respectively). SUVs and first-order greylevel intensity features were not significantly different between low-grade gastric lymphoma and gastric cancer. EntropyGLCM12 was significantly lower in low-grade gastric lymphoma than that in gastric cancer (6.95 vs. 9.14, z = -2.542, P = 0.011) and had an AUC of 0.770 in the ROC analysis of differentiating low-grade gastric lymphoma and gastric cancer.Conclusions:InertiaGLCM and entropyGLCM were the most discriminating features in differentiating gastric lymphoma from gastric cancer and low-grade gastric lymphoma from gastric cancer, respectively. PET TA can improve the differential diagnosis of gastric neoplasms, especially in tumors with similar degrees of fluorodeoxyglucose uptake.

简介：几份临床的报告证实那胃的萎缩是限于成年病人的一个病理不仅。在儿科，它最经常与Hpylori感染而是这联合被描述细菌不似乎是在孩子的这个肿瘤前状态的唯一的病因学的因素。因为他们系统地没在上面的胃肠的内视镜检查法期间被寻求，在孩子的胃的萎缩和肠的组织变形的频率是未知的。childrenosgastropathies的特定的组织学的分类的缺乏为病理学家使他们的诊断困难。迄今为止基于我们的知识，我们认为详细，描述是必要的这损害的自然功课在童年期间。靠近、延长的临床、内视镜的后续为有胃的萎缩的孩子是重要的。

简介：OurpreviousstudyshowedthattwoMKN45variants,namelyMKN45Lm-andMKN45Lm+selectedbylamininadhesioninvitro,haddifferentabilitiesofinvasionandmetastasisinvivo(inoculatedinnudemice)andinvitro(inBoydenchamber),alsohaddifferentexpressionofcysteineproteinase.Inthepresentstudy,weinvestigatedthecellapoptosisofthisMKN45variantsbyTUNELandFACSmethods.Theresultswereshownsignificantdifferentofcellapoptosisinthiscellsublines.TheMKN45Lm-cellshadasmallsubdiploidypeak(3.5%)inDNAcontentanalyzedbyflowcytometry,

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简介：Earlydiagnosisandtreatmentisthekeytoimprovingtheprognosisofgastriccancer.Thepastdecadeshavewitnessedtherapidadvancesinthediagnosisandmanagementofearlygastriccancer(EGC):endoscopyhasplayedanincreasinglyimportantrole,whereaslaparoscopictechniqueshavealsobeenintroducedforEGCtreatment.InChina,the

简介：Esophagealandgastriccancer(GC)arerelatedtoobesityandbariatricsurgery.Riskfactors,suchasgastroesophagealrefluxandHelicobacterpylori,mustbeinvestigatedandtreatedinobesepopulation.Aftersurgery,GCreportsareanecdotalandtreatmentisnotstandardized.ThisreviewaimstodiscussGCrelatedtoobesitybeforeandafterbariatricsurgery.

简介：背景：测试的HIV-1genotypic和phenotypic危险性(通用终端)优化antiretroviral选择，但是它幸存上的效果是未知的。客观：评估在通用终端和幸存之间的协会。设计：队学习。设定：10个美国HIV诊所。病人：为通过2005从1999看见的通用终端(血浆HIVRNA水平>1000copies/mL)合格的2699个感染HIV的病人。大小：人口统计的特征，临床的因素，通用终端使用，所有原因死亡，和为有幸存的通用终端的协会的粗略、调整的危险比率(HR)。结果：病人们被跟随为一3.3年中部；(34%)915有通用终端。把通用终端有的病人比那些降低死亡率(2.0对2.7死亡每100人年)。在标准考克斯模型，通用终端与改进幸存被联系(调整HR，0.69[95%CI，0.51～0.94]；P=0.017)在为临床的后续的人口统计的特征，CD4⁺房间计数，HIVRNA水平，和紧张控制以后。在亚群分析，通用终端与改进幸存被联系因为2107高度活跃的antiretroviral治疗(HAART)经历了病人(2.2对3.2死亡每为有没有通用终端的通用终端对那些的病人的100人年；调整HR，0.60[CI，0.43～0.82]；P=0.002)并且为921个三倍的antiretroviral班富有经验病人(2.1对3.1死亡每100人年；调整HR，0.61[CI0.40到0.93]；P=0.022)。边缘的结构的模型支持了在通用终端之间的协会并且在全面的队改进了幸存(调整HR，0.54；P=0.001)并且在HAART富有经验的组(调整HR，0.56；P=0.003)。限制：通用终端的使用没被使随机化。剩余惊讶可以存在。结论：通用终端的使用独立地在HAART富有经验的病人之中与改进幸存被联系。

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简介：AIM:Tounderstandthecorrelationofserumcholinesterase(CHE)activitywithgastriccancerandtoassesstheirclinicalsignificance.METHODS:ThevelocitymethodwasadoptedtodetecttheactivityofserumCHEinpatientswithgastriccancerandinpatientswithnon-malignanttumorascontrols.RESULTS:TheserumCHEactivityinthetreatmentgroupwassignificantlylowerthanthatinthecontrolgroupwithaverysignificantdifferencebetweenthetwogroups(83.3:113.1,P=0.0003).Agewassignificantlyassociatedwiththeincidenceofgastriccaner.CONCLUSION:SerumCHEactivityhasacloserelationwiththeincidenceofgastriccancer.

简介：SpleencellsfromBalb/cmiceimmunizedwithfivehumangastriccancercelllinesinsequencewerefusedwithmurinemyelomacelllineSP2/0,andhybridomas3F4,3G9and3H11,secretingmonoclonalantibodiees(MoAbs)againstgastriccancer,wereobtainedthroughselectivecultureandscreening.TheseMoAbshavebothgoodselectivityandahighpositiverateofreactionforgastriccancer,reaching5/5and84.8%to93.5%forgastriccancercellsandtissuesrespectively.ThereactionofMoAbswithnormalcellsandtissueswasneglible.ThecorrespondingantigensoftheMoAbsweresensitivetodigestionbytrypsinandpronaseandresistanttotreatmentwithsodiumperiodate,indicatingtheirnatureasproteins.Theantigen3G9couldbevisualizedwithWesternblottingastwobandswithmolecularweightsof100KDand70KD,howevernobandwasfoundforantigens3F4and3H11.Therewasahighexpressionofantigensinthemajorityofgastriccancercellsandtissuesindependentofhis-topathologicaltypeof

简介：瞄准：为了孤立并且识别差别，由二维的电气泳动(2-DE)和帮助矩阵的激光解吸附作用/电离time-of-flight团分光术(MALDI-TOF-MS)表示了在癌症和胃的癌症的正常纸巾之间的蛋白质。方法：胃的癌症纸巾和配对的正常纸巾的可溶的部分蛋白质被2-DE分开。差别表示了蛋白质被MALDI-TOF-MS和数据库搜索选择并且识别。结果：有高分辨率和重制度的2-DE侧面被获得。23个蛋白质点从染色胶化的裂片被切除并且由胰岛素，十五个蛋白质点成功地在被识别在胶化消化了。在识别蛋白质之中，有十过去表示并且在胃癌症纸巾的五下面表示的蛋白质与正常纸巾相比。结论：在这研究，人的胃的癌症织物和配对的正常织物的解决得好的、可再现的2-DE模式被建立并且优化并且某些表示差别的蛋白质被识别。2-DE和MS的联合使用提供一条有效途径为潜在的肿瘤标记屏蔽。

简介：Monoclonalantibody(MAb)toratlivercyto-chromeP-450jisozyme,anactivatingenzymespecifictonitrosaminemetabolism,wasusedcoupledwithimmunoblotting,densitometerscanningofSDS-PAGEgelsandimmunohistochemicaltechnique.ThetraceP-450HSjisozyme(Mr.51.5Kd)wasfoundinhumangastricmucosa.ItwassimilartoP-450jinmolecularweight,catalyticandimmunochemicalproperties.TheconcentrationsofP-450HSjinmucosaoflessercurvaturewerehigherthanthoseingreatercurvature.Thismightbeoneoftheimportantreasonsthatlessercurvatureisthecommonestareaforgastriccarcinoma.ButtherewaspossiblylessP-450HSjingastricmucosawithcancer.Im-munohistochemically,P-450HSjwasdiscoveredinthecytoplasmofsomeglandularepithelialcells,especiallyintheglandswithhyperplasticandintestinalmetaplasticchangesadjacenttocarcinoma.Itwasalsofoundinsomenormalglandsandintumorcellsofhigh-differentiatedadenocarcinoma,butnotinthoseoflow-differentia