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简介：TheobjectiveofthisstudyistoexploreapotentiallyeffectivetrainingmethodforthehospitalprofessionalstoeducatedrugusersandtoenhancetheirknowledgeofHIVinfection.Onehundredandsixtyonesubjects,whocamefrom13differentprovincesandwereadmittedinadrugreliefhospitalinBeijing,wererecruitedforthisstudy.Theaverageageofthesesubjectswas35.21±6.24yearold.Theaveragenumbersofyearsfordrugaddictionwere7years,andtheaveragenumbersofdrugrelieftreatmentreceivedinthepastwas5.5times.ThelevelofAIDSknowledgeofthesesubjects,includingpathogenicfactors,sourceofinfection,routeoftransmissionandpreventivemeasures,wereevaluatedbeforeandafterreceivingtheAIDSeducationaltrainingtothesedrugusers.Ourresultsshowedthattherewasastatisticallysignificantincrease(P＜0.01)intheknowledgeofHIVinfectionandpreventionamongthesesubjects.PositiveattitudeandbehavioraltendenciestowardHIVpreventionwerealsoimproved.Therefore,itisimperativeforthemedicalprofessionalstoincorporateAIDSeducationintodrugrelieftreatmenttoachievethemaximumeffectontheknowledgeofAIDSandimprovementofpositiveattitudesandbehaviorstowardHIVpreventionamongdrugusers.

简介：人被自然选择进化到目前在自然生物圈中的地位，因故人的生命是坚强的。于是，作为自然的主宰，人创造了许多是自然原本没有的“东西”，这些人为的“东西”既给纯朴的自然描绘上了华丽的色彩，同时也给自然带来了不少的灾难，源于这些灾难，人的生命随时随地都可能发生“差错”，这又折射出人生命的脆弱。为了保护自己，人便创造了医学，也发明了药物，以便能在这许许多多的“差错”之中拯救人的生命于危验。

简介：INTRODUCTIONSincetheirintroductioninmid-1980s,polyamidoamide(PAMAM)dendrimershaveattractedconsiderableattentionbecauseoftheiruniquestructuresandproperties.Accordingtopreliminarystudiesinanimals,PAMAMdendrimersarenon-immunogenic,verylowinvivotoxicityandcanbeexcretedbyurineandfeces.

简介：AnewclassofcrosslinkingpolyphosphatesweresynthesizedandcharacterizedbyIR^1HNMR,^31PNMRspectroscopyaswellaselementalanalysis.InvitrodegradationofthepolyphosphatesobtainedandthereleaseofantineoplasticdrugMethotrexate(MTX)andcontraceptiveLevonorgestrel(LNG)byusingthesepolymersasmatrixwerestudied.ZeroorderreleaseratewasobservedinthecaseofLNGrelease.

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简介：Abstract:ChlamydiaTrachomatis(C.T.)isoneofthemostcommonpathogensofhumansexuallytransmitteddiseases.TreatmentofC.T.infectionprimarilydependsonTetracyclines,MacrolidesandQuinolones,butwiththewideuseofantibioticsanincreasingnumberofdrug-resistantChlamydiatrachomatiscaseshavebeenreported.ThisreviewsummarizestheresistantconditionsandthepossibleresistancemechanismsofC.T..

简介：Adetectionofanthracyclineantitumordrugdaunomycin(DNR)reactingwithDNAinsimulatemetabolisminvitrohasbeenmade.ItwasfoundthatDNRcouldreactwithDNAtoformDNR-DNAadducts.TheadductcompositionsofDNRwithfishspermDNAandthermallydenaturatedDNAweredetermined.TheequilibriumassociationconstantKofDNRwithfishspermDNAis1.98×10^5L/molandthatofDNRwithdenaturatedDNAis2.29×10^4L/mol.Semiquinonefreeradicals,metabolicproductsofDNR,candestroybothfishspermDNAanditsthermallydenaturatedDNA.ItisverifiedbyhyperchromiceffectincreaseobservedinUVspectrumandAFMexperiments.ThemechanismofDNAdegradationhasalsobeeninvestigated.Resultsobtainedallowonetoexplainthereasonofsideeffectofanthracyclinedrugandgivethewaytodepress,whichwereofclinicalsignificance.

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简介：Aschemeisproposedtoelevatethelimitationofthegroundapplicationsystemofmono-satellite-sensorundertherequirementofremotesensingsatellitegroundapplicationsystem.Intheresource-sharing,forinstancecaculatingresource,asimplephototypeofcaculating-resourceisproposedthroughanalyzingresourceassignment,applicationassignment,bodystructure,andsoon.Inordertoimprovetheabilityofassignment,realizethefavorableutility,management,andmaintenance,thephototypeisimprovedbyusingdatagridcalculationaccordingtotherequirementandcharacterofactualapplication.Thephototypecanbetakenasthefoundationofcalculationframeofremotesensinggroundapplicationsystemofmulti-satelliteandmulti-sensor.

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简介：Objective:Toclonemultidrugresistance(MDR)relatedgenesinlungadenocarcinomacelllines.Methods:ThedifferentiallyexpressedcDNAfragmentsbetweenA549andA549DDPcellswereanalyzedbymRNAdifferentialdisplayPCR(DDRT-PCR).ThefragmentsthusobtainedwerefurtheranalyzedbyDNAsequencingandNorthernblotting.Results:ThreedifferentiallyexpressedcDNAfragmentswereobtainedandconfirmedbyNorthernblot.Sequenceanalysisrevealedthattwoofthemwerenovelandonewas100%identicalwithICEgene.Conclusion:AnalyzingdifferentiallyexpressedfragmentbetweenA549andA549DDPcellsmaybehelpfulforfindingnewMDRrelatedgenes.ThedrugresistanceofA549DDPcellsmayberelatedtotheinhibitionordown-regulationofICEgene.

简介：Mitoxantrone,aclinicallyusefulantitumourantibioticforleukaemiaandbreastcancer,hasreceivedmoreattentions.Inthispaper,theinteractionbetweenmitoxantroneandcalfthymusDNAisinvestigatedbyRamanandfluorescencespectroscopies,andthebindingsiteofmitoxantronetocalfthymusDNAisexplored.TheresultsshowedthatmitoxantroneinteractswithcalfthymusDNAbasesbytheintercalationofanthracyclineintothebasepairplaneofadenine(A)andthymine(T),anditresultsinthedisruptionofthehydrogenbondsbetweencalfthymusDNAbases,andthusthecalfthymusDNAdouble-strandcanbedisruptedintotheB-formDNAdouble-strandsegments.

简介：Toenhancetheexpressivepowerandthedeclarativeabilityofadeductivedatabase,variousCWA(ClosedWorldAssumption)formalizationsincludingthenaiveCWA,thegeneralizedCWAandthecarefulCWAareextendedtomulti-valuedlogics.Thebasicideaistoembedlogicformulasintosomepolynomialring.Theextensionscanbeappliedinauniformmannertoanyfinitelymulti-valuedlogics.Thereforetheyarealsoofcomputationalsignificance.

简介：Anewall-opticaldemultiplexerbasedonnonlineareffectinsemiconductorlaseramplifier(SLA)isproposed.ItcandemultiplexallchannelsoftheOTDMsignalconcurrently.anditcanalsobeintegratedonasinglechip.TheproposeddeviceconsistsofaseriesshortFabry-Perotamplifiers(FPSLA)settingonthepathverticsally,throughwhichthepreamplifiedopticalsignaltravels.Perpendicularlytothesignal,K(channelnumber)paralleledbeamsoflightpulse,whichactasprobeswithrepetitionatthebitrateofonechannel,irradiateontheseFP-SLAs,respectively,justwhenthecorrespondingsignalchannelpulsepassesthroughtheactiveregionfromlateralside.Thetransmissivitydependsonthesignalpulse.Theoreticalanalysishasbeengiven.Asademonstratingexample,Adeviceoperatedatthespeedof25Gbit/s(2.5Gbit/s×10)issimulatedandtheresultsshowthattheabout9.24dBextinctionratiocanbeachievedeasily.

简介：Yinshananticlineistheproductoftectono-dynamicdeformation-metamorphism.Alongtheaxisoftheanticlineexistsabrittle-ductileshearingzonewhichobviouslycontrolstheore-formation.Mineralizationoccursalongtheaxisoftheanticlineinawidthofabout1000m.Intheminingarea,volca-no-subvolcanicrocksofEarlyYanshanperiodaredividedintothreecycles:Iintermediateacidicdacitelavaanddaciteporphyry;Ⅱacidicamphibolelipariteandquartzporphyry;Ⅲintermediateandesiteporphyrite.AmongthemactivitiesofⅠandⅡcyclesaremoreintensiveandareintimatelyrelatedtothemineralization.Yinshanoredepositistheresultofcombinativeprocessesoftectono-dynamicandvolcano—magmatichydrothermalfluids,sothattherearetwocentersofmetallogeniczoning,onebeingtheaxialstrainzoneofYinshananticlinewhichisthecenteroffirstorder,andtheotherbeingporphyrystock,2ndorder.