简介：DearEditor,IamDr.KhayWeiPohfromDepartmentofOphthalmology,HospitalKualaLumpur,Malaysia.IwritetoshareacaseofdiffusechoroidalhaemangiomainachildwithSturgerWebersyndromewhoshowedresolutionofexudativeretinal

简介：Adolescenceisakeyperiodinhumandevelopment,inwhichyoungpeopleareexposedtodangeroussituations,oneofthosedangersistheriskofparticipatingincriminalorillicitactivities.Thisarticlefocusesonthetreatmentofadolescentswhoareinconflictwiththelaw.Itdescribesthemodelfortheevaluationofriskofviolenceandrecidivism.Itdescribestheinstrumentsfortheevaluationthatareavailabletotheyoungpeoplewhoareinternedforcriminalbehavior.Italsodescribes,indetail,theInventoryformanagementandInterventionforyoungpeople.IGI-J,italsodescribesthemosteffectivetreatmentmodeluptodaterelatedtocriminalrecidivisminadolescentsanditsimplications.

简介：Anewtechnologythatsimulatestumorshasbeenshowntoperformaswellasresearchanimalsintestingchemotherapydrugs,representingapotentialtoolforscreeningdrugsbeforetreatingapatient.Along-termgoalistoincorporatebiopsiedcancercellsfrompatientsandtesttheeffectivenessofdifferentdrugsonthepatient-derivedcells.

简介：Developingtheradiographicimagesfromtwotothree-dimensional,finiteelementanalysis(FEA)technologycansetupthemodel,predictingdiagnosis,treatmentdesign,aswellassurgicalplan.FEAprovidesanaccuratethree-dimensionalfiniteelementbiomechanicalstudyinosteonecrosisoffemoralhead(ONFH).Thepapersinthelatest5yearsrelatedtofemoralheadosteonecrosisandfiniteelementanalysisapplicationareconcentratedon.Wesummarizethelatestresearchprogressandproblems,includingtheappliedresearchcarriedoutinthefemoralheadosteonecrosisclinicalcases,innovationalskills,soastopointoutthedirectionoffutureresearchinFEA.

简介：Benignparoxysmalpositionalvertigo(BPPV)isthemostfrequentepisodicvestibulardisorder.Itisduetootolithreststhatarefreeintothecanalsorattachedtothecupulas.Wellover90%ofpatientscanbesuccessfullytreatedwithmanoeuvresthatmovetheparticlesbacktotheutriculus.Amongthegreatvarietyofproceduresthathavebeendescribed,themanoeuvresthataresupportedbyevidenced-basedstudiesorextensiveseriesarecommentedinthisreview.SometopicsregardingBPPVtreatment,suchascontrollingtheaccuracyoftheproceduresortheutilityofpost-manoeuvrerestrictionsarealsodiscussed.

简介：Strokeisaleadingcauseofdisabilityanddeath,yeteffectivetreatmentsforacutestrokehasbeenverylimited.Thusfar,tissueplasminogenactivatorhasbeentheonlyFDA-approveddrugforthrombolytictreatmentofischemicstrokepatients,yetitsapplicationisonlyapplicabletolessthan4–5%ofstrokepatientsduetothenarrowtherapeuticwindow(<4.5hoursaftertheonsetofstroke)andthehighriskofhemorrhagictransformation.Emergingevidencefrombasicandclinicalstudieshasshownthattherapeutichypothermia,alsoknownastargetedtemperaturemanagement,canbeapromisingtherapyforpatientswithdifferenttypesofstroke.Moreover,thesuccessinanimalmodelsusingpharmacologicallyinducedhypothermia(PIH)hasgainedincreasingmomentumforclinicaltranslationofhypothermictherapy.Thisreviewprovidesanupdatedoverviewofthemechanismsandprotectiveeffectsoftherapeutichypothermia,aswellastherecentdevelopmentandfindingsbehindPIHtreatment.ItisexpectedthatasafeandeffectivehypothermictherapyhasahightranslationalpotentialforclinicaltreatmentofpatientswithstrokeandotherCNSinjuries.

简介：Schwannomasareneurogenictumorsthatarisefromtheneuralsheathsofperipheralnerves.Thesetumorscanbelocatedinanyareaofthehumanbody;themostcommonlocationsarethehead,neck,trunkandextremities.Pancreaticschwannomasareveryrare.Overthepast40years,only67casesofpancreaticschwannomashavebeenreportedintheEnglishliterature.Herewepresentacaseofpancreaticschwannomaina62-year-oldmale.Thetumorwasrevealedbyultrasoundandcomputedtomographyintheneckandbodyofthepancreas.Anaccuratediagnosiswasdifficulttoobtainpreoperatively.Thepatientconsentedtotheperformanceofalaparotomy,andthemasswasfoundintheneckandbodyofthepancreasandsuccessfullytreatedusingaspleenpreservingdistalpancreatectomywithsplenicarteryandveinpreservation.Theprocedurehasonlybeenreportedinoneothercaseofpancreaticschwannoma;herewepresentthesecondreportedcase.Macroscopically,thetumorwaswellcircumscribed,gray-whiteincolorand3.3cm×2.8cminsize.Microscopically,thetumorcellswerespindle-shapedandhadapalisadingarrangementwithnoatypia,whichareresultscompatiblewithabenigntumor.Bothhypercellularandhypocellularareaswerevisible.Immunohistochemically,thetumorcellswerestronglypositiveforS-100protein.Thetumorwasdefinitivelydiagnosedasaschwannomaofthepancreaticneckandbody.Thepatientwasfollowedfor72moandhasbeendoingwellwithoutanycomplications.

简介：EpidemiologicalstudiesshowedtheincidencemortalityratesofcancerwereincreasinginrecentdecadesinChinesepopulation.Nationalandregionalpreventiveprogramsaimtoreducethehealthhazardsofcancerandfocusethepopulationathighrisksforspecificcancer,particularlyinruralareasandtooffertheaccesstoearlydetectionformultlplecancersinurbanareas.Theearlyscreening,earlydetectionandtreatmenthavebeenputintooperationforthepopulationatrisksinruralareasatfirst,andintheurbanareasinrecentyears.Tounderstandtheepidemicpatternsandtrendsofcancer,andtheexperiencesinapplyingearlydetectionstrategiesinChina,selectedliteratureswerereviewedforbriefsummary.

简介：在在JAMA和JAMA实习生Med出版的一系列使随机化的控制试用，美国研究人员与睾丸激素层次在老人检验了睾丸激素治疗的效果1，1认知功能，2贫血症，3并且容量的骨头density.4当试用在贫血症和骨头密度关于改进显示出积极结果时，长术语的研究被要求描出在这张人口的长期的风险和好处。

简介：Inthispaper,acryosurgery-hyperthermiasystemisproposedfortakingadvantageofthealternatedcoolingandheatingtreatmentintumor.Anovelcontrolsystemisproposedtoensurethatthethermalsystemworkseffectively.Firstly,thetissuetemperaturearoundtheprobeisregulatedandkeptinadesiredrangewhenradiofrequencyablationisoperated.Secondly,precisecontroloftemperatureisachievedinhyperthermiatreatmentusingfuzzylogicPIDtypecontroller.Theresultsofexvivoliverexperimentdemonstratethatthissystemcouldprovidearathergoodperformancewiththeproposedcontrolmethod.

简介：Theincidenceofpapillarythyroidcarcinoma(PTC)hasexponentiallyincreasedinrecentyears.Papillarythyroidmicrocarcinoma(PTMC)accountsforthemajorityofthereportedcasesofPTC.ThedebatesandcrucialissuesinPTMCmanagementhavereceivedresearchers'attention.TofurtherimprovetheclinicalmanagementofPTMCinChina,

简介：Acutecoronarysyndrome(ACS)isthemaincauseofdeathworldwideandtheleadingcauseofdiseaseburdeninhigh-incomecountries.ACSreferstoaconstellationofclinicalsymptomsthatarecompatiblewithacutemyocardialischemia.Itdescribesaspectrumofclinicalmanifestationsthatresultfromacommonpathophysiologicalprocess.ThemostcommoncauseofACSareruptureofanatheroscleroticlesioncontainingalargenecroticcoreandathinfibrouscapfollowedbyacuteluminalthrombosis.Itwasthoughtthatahigh-resolutionimagingmodalitywouldbeidealtodetecthigh-riskplaquesbeforetheirdisruptionandtheformationofanocclusivethrombus.Opticalcoherencetomographyhasproventobeaninvaluabletoolinearlydetectionofhigh-riskplaquesandparticularlyintheunderstandingofACS.ThisreviewfocusesonthecurrentevidencefortheroleofopticalcoherencetomographyinthediagnosisandtreatmentofpatientswithACS.

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简介：Familialdysautonomia(FD)isararechildrenneurodegenerativediseasecausedduetoapointmutationintheIKBKAPgenethatresultsindecreasedIKKcomplex-associatedprotein(IKAP)proteinproduction.Thediseaseaffectsmostlythedorsalrootganglion(DRG)andthesympatheticganglion.Recently,wefoundthatthemolecularmechanismsunderlyingneurodegenerationinFDpatientsaredefectsinaxonaltransportofnervegrowthfactorsandmicrotubulestabilityintheDRG.Neuronsarehighlypolarizedcellswithverylongaxons.Inordertosurviveandmaintainproperfunction,neuronsdependontransportofproteinsandothercellularcomponentsfromtheneuronalbodyalongtheaxons.WefurtherdemonstratedthatIKAPisnecessaryforaxonmaintenanceandshowedthatphosphatidylserineactsasanHDAC6inhibitortorescueneuronalfunctioninFDcells.Inthisreview,wewillhighlightourlatestresearchfindings.

简介：OBJECTIVE:Theaimofthisstudywastoevaluatetheeffectivenessandsafetyofstemcelltransplantationforspinalcordinjury(SCI).DATASOURCES:PubMed,EMBASE,Cochrane,ChinaNationalKnowledgeInfrastructure,ChinaScienceandTechnologyJournal,Wanfang,andSinoMeddatabasesweresystematicallysearchedbycomputertoselectclinicalrandomizedcontrolledtrialsusingstemcelltransplantationtotreatSCI,publishedbetweeneachdatabaseinitiationandJuly2016.DATASELECTION:RandomizedcontrolledtrialscomparingstemcelltransplantationwithrehabilitationtreatmentforpatientswithSCI.Inclusioncriteria:(1)PatientswithSCIdiagnosedaccordingtotheAmericanSpinalInjuryAssociation(ASIA)InternationalstandardsforneurologicalclassificationofSCI;(2)patientswithSCIwhoreceivedonlystemcelltransplantationtherapyorstemcelltransplantationcombinedwithrehabilitationtherapy;(3)oneormoreofthefollowingoutcomesreported:outcomesconcerningneurologicalfunctionincludingsensoryfunctionandlocomotorfunction,activitiesofdailyliving,urinationfunctions,andseverityofSCIoradverseeffects.Studiescomprisingpatientswithcomplications,withoutfull-text,andpreclinicalanimalmodelswereexcluded.QualityoftheincludedstudieswasevaluatedusingtheCochraneriskofbiasassessmenttoolandRevManV5.3software,providedbytheCochraneCollaboration,wasusedtoperformstatisticalanalysis.OUTCOMEMEASURES:ASIAmotorscore,ASIAlighttouchscore,ASIApinprickscore,ASIAimpairmentscalegradingimprovementrate,activitiesofdailylivingscore,residualurinevolume,andadverseevents.RESULTS:Tenstudiescomprising377patientswereincludedintheanalysisandtheoverallriskofbiaswasrelativelylowlevel.Fourstudiesdidnotdetailhowrandomsequencesweregenerated,twostudiesdidnotclearlystatetheblindingoutcomeassessment,twostudieslackedblindingoutcomeassessment,onestudylackedfollow-upinformation,andfourstudiesc

简介：Microbe-inducedcalciteprecipitationisasustainableimprovementtechniqueforsandysoil,whichcanalterthepropertiesofsandviamicrobialactivity.Inthisstudy,weinvestigatedtheloose-sand-consolidationeffectbycontrollingtheinjectionvelocity,bacterialandcementingsolutionconcentrations,andholdtimes.Theresultsdemonstratethat,asthecyclicbatchincreases,theutilizationrateofthebacterialfluidincreasesandboththeopticaldensity(OD600)ofthebacteriaandureaseactivitydecrease.Moreover,itwasdeterminedthata3-hholdtimefora0.5mol/Lcementingsolutionwithacementingfluidvelocityof2mL/minhasthegreatestbondingeffect.Thefinalstrengthoftheloosesandwithanincreaseincalciumcarbonatecontentwasfurtherdiscussed.

简介：这研究在跟随加速的transepithelial的keratoconus角膜评估了临床的结果角膜的骨胶原cross-linking(CXL)(AvedroKXL?系统，麻省沃尔瑟姆，美国)超过一年后续。光连贯断层摄影术(10月)测量的分界线的吝啬的深度是205.19???吳????????<

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简介：Objective:Thepurposeofthismeta-analysisistodeterminewhetherplatingorintramedullarynailing(IMN)foradultdiaphysealboth-boneforearmfractures(BBFF)providesbetterclinicaloutcomes.Methods:MEDLINE,EMBASE,GoogleScholarandTheCochraneLibrarywerecomprehensivelysearcheduntilJuly31,2016.BothretrospectivestudyandprospectivetrailsaboutcomparisonofdualIMNorhybridfixationversusdualplatingfixationinthetreatmentofadultdiaphysealBBFFwereincluded.UsingRevMan5.3software,dataoffunctionalrecovery,theuniontime,operatingtimeandcomplicationwasextractedformeta-analysis.Results:Thepooledanalysisshowedsimilarresultsintheuniontime,functionalrecoveryandtheratesofcomplications,butshowedasignificantdifferenceinoperatingtime.Conclusion:Thismeta-analysisdemonstratessimilarradiographicoutcomes,functionaloutcomesandcomplicationswithplatesorIMNusedinthetreatmentofadultdiaphysealBBFF.IMNfixationforthesefracturesseemstobeanalternativeandeffectivetreatmentwithshorteroperatingtimesandminimallyinvasive.

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