简介：AbstractInterleukins (ILs) and associated cytokines serve as the means of communication for immune cells and non-immune cells. The use of ILs in harnessing the immune system to cancer treatment has been a promising approach. ILs not only nurture an environment enabling cancer growth but also simultaneously trigger a productive tumor-directed immune response. These properties of ILs are increasingly being explored as a strategy to improve the outcomes of cancer. Here, we describe recently innovative technological approaches that have been developed to improve the pharmacokinetics, safety, and efficacies of IL-2, 15, 10, and 18 in the treatment of melanoma. Furthermore, the combination of ILs and immune checkpoint inhibition may synergize to reshape the tumor environment, thus yielding better clinical benefits in the future.

简介：应用针剌结合耳穴贴压方法治疗老年人呃逆。针剌的主穴是内关，足三里和天突。年老体虚病重者加气海和太溪，脑血管疾病者加攒竹，消化道疾病及便秘者加支沟，呼吸道疾病者加合谷。同时贴压耳穴膈，胃。耳神门，交感，皮质下和肾。结果痊愈45例，好转10例．有效率100％。

简介：AbstractTuberculosis (TB) is among the deadliest infectious diseases worldwide. Although the existing antituberculosis (anti-TB) drugs remain to be effective, the administration of these complex anti-TB drug combinations with obvious toxicity often leads to patients’ nonadherence. This may contribute toward the emergence of drug-resistant strains as well as lead to treatment failure and relapse. Therefore, in the past half century, the main focus of anti-TB drug research was to reduce the frequency of administration and toxicity and improve patients' compliance and drug sensitivity. Following these principles, the development of engineered biosafety materials is one of the most effective and promising methods in resolving these challenges. Compared with traditional drugs, biosafety materials provide a viable platform for treating TB, which are beneficial in reducing the frequency of drug administration and systemic toxicity, improving patients’ compliance and drug sensitivity, and enhancing drug targeting. In this review, we summarized the application of biosafety materials in treatment of TB in recent years and discussed the challenges faced when developing a safe, more effective, and economical pharmacotherapy against TB.

简介：Primaryesophagealadenocarcinoma(PEAC)isararemalignantdiseaseofesophagus.Becauseofitslowerincidence,theknowledgeaboutitislimitedandtherearesomeproblemsrequiringfurtherstudy.Duringrecent30years,106patientswithPEAChadbeentfeatedsurgicallyinourdepartment...

简介：Theuseoflaparoscopyhasbeenestablishedinimprovingperioperativeandpostoperativeoutcomesforpatientswithsimpleappendicitis.Laparoscopicappendectomyisassociatedwithlesswoundpain,lesswoundinfection,ashorterhospitalstay,andfasteroverallrecoverywhencomparedtotheopenappendectomyforuncomplicatedcases.Inthepasttwodecades,theuseoflaparoscopyforthetreatmentofperforatedappendicitistotaketheadvantagesofminimallyinvasivenesshasincreased.Thisarticlereviewedtheprevalence,approaches,safetydisclaimers,perioperativeandpostoperativeoutcomesofthelaparoscopicappendectomyinthetreatmentofpatientswithperforatedappendicitis.Specialissuesincludingtheconversion,intervalappendectomy,laparoscopicapproachforelderlyorobesepatientarealsodiscussedtodefinetheroleoflaparoscopictreatmentforpatientswithperforatedappendicitis.

简介：<正>OtitisMediaisacommondiseaseinthepracticeofotolaryngologyandoneofthefamous"threeinflammationsandonedeafness".Otitismediahasbeenwithhumansfromtheverybeginning.Treatmentforotitismediastartedinthewestin1774andmuchlaterinChina.

简介：Althoughmanytraditionaltherapiesareavailableforgenitalwarts(GW)，oneofthemajorproblemsinthetreatmentofGWisahighrecurrenencerate．Inordertoresolvetheproblemofrecurrence，newtheraputicapproacheshavebeeninvestigated．Newapproachesbeingexploredinclude5-fluorouracil／epinephrineinjectablecollagengel,5％imiguimodcreamandhumanpapillomavirusvaccine．Fluorouracil／epinephrineinjectablecollagengelachieveshighconcentrationoffluorouracilatthesiteofinjection．Imiguimodisanovelimmune-responesmodifier,givinggoodclearanceratesandtolerablesideeffects．AlthoughtheuseofanHPVvaccineisfaraway，preliminarystudiesshowthatitmaybepossibletodevelopsuitableprophylacticandtherapeuticvaccinestogenitalwarts．

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简介：瞄准：与高潮的机能障碍在人的治疗学习育亨宾硷的效果。方法：育亨宾硷的A20-mg剂量首先在诊所与不同原因论的高潮的机能障碍被给29个人。病人们然后被允许在更赞成的情形下面在家(滴定)增加剂量。结果和副作用随后被估计。结果：病人被分类进三组高潮的机能障碍：主要完全(13)，主要不完全(8)并且第二等(8)。梦遗在75%,40%是在场的，在上面的50%病人组织，分别地(总的来说平均62%)。因为富饶问题(52%)，介绍的人或因为他们想要经历高潮(48%)的快乐。完成了治疗的29个病人，16设法到达高潮并且也在手淫或性交期间是有能力的脚趾投掷。进一步，三完成了的A达到高潮，但是仅仅与一个震荡器的另外的刺激。前面的梦遗的历史在高潮在被劝诱的69%人是在场的但是仅仅50%没有通过治疗。病人，二随后生了孩子(双胞胎的一个集合)，3个人也是的另外一个治好。副作用不是足够的引起这些人停止治疗。结论：Yohimbineis在高潮的机能障碍的一种有用治疗选择。

简介：56patientswithtinnitusweretreatedforthreeweeksintheInselkinikHefingsdorfincompetencecenteroftinnituswithacupuncture,modempsychosomatictherapy,alliedwithhyperbaricoxygentherapy.TheTCMinterventionconsistedofmedicalacupuncturetwiceaweekand“Fivedementspalm”Qi-gongtrainingthreetimesperweek.SpecificconstellationofacupuncturepointswerechosenaccordingtotheprescriptionoftraditionalChinesestandardsandmodifiedtowelltestedpreprovedacupuncturestudy.

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简介：AbstractBackground:Early treatment for patients with aneurysmal subarachnoid hemorrhage (aSAH) could significantly reduce the risk of re-bleeding and improve clinical outcomes. We assessed the different time intervals from the initial hemorrhage, admission, and endovascular treatment and identified the risk factors contributing to delay.Methods:Between February 2017 and December 2019, 422 consecutive aSAH patients treated in a high-volume hospital were collected and reviewed. Risk factors contributing to admission delay and treatment delay were analyzed with univariate and multivariate analysis.Results:One hundred twenty-two (28.9%) were admitted to the high-volume hospital at the day of symptom onset and 386 (91.5%) were treated with endovascular management at the same day of admission. The multivariate analysis found that younger age (P = 0.022, OR = 0.981, 95% CI 0.964-0.997) and good Fisher score (P = 0.002, OR = 0.420, 95% CI 0.245-0.721) were independent risk factors of admission delay. None was found to be related with treatment delay. Multivariate analysis (OR (95% CI)) showed that higher age 1.027 (1.004-1.050), poorer Fisher score 3.496 (1.993-6.135), larger aneurysmal size 1.112 (1.017-1.216), and shorter interval between onset to admission 1.845 (1.018-3.344) were independent risk factors of poorer clinical outcome.Conclusion:Treatment delay was mainly caused by pre-hospital delay including delayed admission and delayed transfer. Our experience showed that cerebrovascular team could provide early treatment for aSAH patients. Younger age and good Fisher score were significantly related with admission delay. However, admission delay was further significantly correlated with better clinical outcome.

简介：目的：研究针灸结合中药治疗黄褐斑的效果。方法：把黄褐斑分成3型，予以针灸结合中药内服、外敷治疗。结果：针灸结合中药治疗黄褐斑有明显的效果，45例经2个疗程治疗后，有效率达93．3％。结论：针灸结合中药治疗黄褐斑有明显的效果。

简介：ＴｈｅｔｈｅｒａｐｅｕｔｉｃｐｒｉｎｃｉｐｌｅｓｏｆＡｌｚｈｅｉｍｅｒ’Ｄｉｓｅａｓｅｗｅｒｅｒｅｐｌｅｎｉｓｈｉｎｇｖｉｔａｌｅｎｅｒｇｙａｎｄｉｎｖｉｇｏｒａｔｉｎｇｂｌｏｏｄｃｉｒｃｕｌａｔｉｏｎ,ｉｎｖｉｇｏｒａｔｉｎｇｆｕｎｃｔｉｏｎｏｆｔｈｅｓｐｌｅｅｎｔｏｒｅｓｏｌｖｅｐｈｌｅｇｍ,ｓｔｒｅｎｇｔｈｅｎｉｎｇｔｈｅｍａｒｒｏｗｂｙｒｅｉｎｆｏｒｃｉｎｇｔｈｅｆｕｎｃｔｉｏｎｏｆｔｈｅｋｉｄｎｅｙ,ｉｎｖｉｇｏｒａｔｉｎｇｂｌｏｏｄｃｉｒｃｕｌａｔｉｏｎｔｏｅｌｉｍｉｎａｔｅｂｌｏｏｄｓｔａｓｉｓ.Ｔｈｅｍａｉｎｔｈｅｒａｐｅｕｔｉｃａｃｕｐｏｉｎｔｓｗｅｒｅａｓｆｏｌｌｏ

简介：AbstractOxidative stress is caused by the imbalance between the generation of free radicals/reactive oxygen species (ROS) and the antioxidant defense systems, which can activate various transcription factors and affect their transcriptional pathways. Oxidative stress plays an important role in the occurrence and development of leukemia and is closely related to the treatment and prognosis of leukemia. The standard chemotherapy strategies for the pre-treatment of leukemia have many drawbacks. Hence, the usage of antioxidants and oxidants in the treatment of leukemia is being explored and has been preliminarily applied. This article reviews the research progress of oxidative stress and leukemia. In addition, the application of antioxidants treatment in leukemia has been summarized.

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简介：Statusasthmaticusisaformofbronchialasthmaattack.Thesevereonecancausefailureofrespiratoryfunction.Toalleviatethesymptomsquickly,routinetherapycouldcombinedwithcompoundsalviamiltrorrhizainjectionandvitaminK3.Comparedthe36patientsintwogroupsandfoundtheeffectswereobvious.Intravenousdripwithcompoundsalviamihiorrhizainjectioncandilatethevessel,improvethemicrocirculationandpulmonarycirculation,correctoxygendeficitandquickelydispelsputum,thusit'sconductivetotheeliminationofconvulsionofairway.VitaminK3canpromotethesynthesisandconversionofcyclicAMPandalleviatetheinflammatoryexudation,thusimproveandstrengthenthefunctionofventiliation.

简介：Glioblastoma(GBM)isatypeoftumorthatishighlylethaldespitemaximaltherapy.Standardtherapeuticapproachesprovidemodestimprovementinprogression-freeandoverallsurvival,necessitatingtheinvestigationofnoveltherapies.Oncologictherapyhasrecentlyexperiencedarapidevolutiontoward'targetedtherapy',withdrugsdirectedagainstspecifictargetswhichplayessentialrolesintheproliferation,survival,andinvasivenessofGBMcells,includingnumerousmoleculesinvolvedinsignaltransductionpathways.Inhibitorsofthesemoleculeshavealreadyenteredorareundergoingclinicaltrials.However,significantchallengesintheirdevelopmentremainbecauseseveralpreclinicalandclinicalstudiespresentconflictingresults.Inthisarticle,wewillprovideanup-to-datereviewofthecurrenttargetedtherapiesinGBM.

简介：AcupunctureTreatmentfor54DisorderswaswrittenbyHuangQinfengandQiLizhen,andpublishedbyShanghaiScientific&TechnicalPublishersin2002.Thebookcollected54commondisordersinclinicfromabout5451articlespublishedinhundredsjournalsbetween1980and