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简介：CMV特定的免疫为人的cytomegalovirus(HCMV)的控制是必要的感染。干细胞移植在hemopoietic系统的疾病的一个范围的管理广泛地被使用。病人们在早posttransplant时期深刻地是immunosuppressed，并且cytomegalovirus(CMV)的复活仍然是病态和死亡的一个重要原因。CMV特定的CD8+T房间克隆的采纳转移被显示了减少病毒的复活的率；然而，为采纳转移的房间的前vivo生产是集中、昂贵的劳动。我们这里用CMV特定的epitope肽报导一个修改肽刺激方法为CMV特定的CTL的产生刺激PBMC。这个方法允许CMV特定的CTL的有效扩大并且从一件单个血样品为FACS分析提供很多房间。显著地，它完成允许容易要比较并且顺序评估了的不同个人的数据的CD8+T房间染色的tetramer的高频率。因此，这条途径为潜在的采纳免疫疗法扩展并且选择高特性的限制HLA的CMV-pp65-reactiveT房间线。

简介：Westudytheparametricamplificationofelectromagneticallyinducedtransparency-assistedRydbergsix-andeight-wavemixingsignalsthroughacascadednonlinearopticalprocessinahotrubidiumatomicensembleboththeoreticallyandexperimentally.Theshiftoftheresonantfrequency（inducedbytheRydberg-Rydberginter-action）ofparametricallyamplifiedsix-wavemixingsignalisobserved.Moreover,theinterplaysbetweenthedressingeffectsandRydberg-Rydberginteractionsinparametricallyamplifiedmultiwavemixingsignalsarein-vestigated.ThelinearamplificationofRydbergmultiwavemixingprocesseswithmultichannelnatureactsagainstthesuppressioncausedbyRydberg-Rydberginteractionanddressingeffect.

简介：Objective:ThisstudyaimstoestablishamethodforhighlyparallelmultiplexeddetectionofgeneticmutationsinChineselungcancersamplesthroughAgenaiPLEXchemistryandmatrix-assistedlaserdesorptionionizationtime-of-flightanalysisonMassARRAYmassspectrometryplatform.Methods:Wereviewedtherelatedliteratureanddataonlungcancertreatments.Wealsoidentified99mutationhotspotsin13targetgenescloselyrelatedtothepathogenesis,drugresistance,andmetastasisoflungcancer.Atotalof297primers,composedof99pairedforwardandreverseamplificationprimersand99matchedextensionprimers,weredesignedusingAssayDesignsoftware.Thedetectionmethodwasestablishedbyanalyzingeightcelllinesandsixlungcancerspecimens.TheproposedmethodwasthenvalidatedthroughcomparisonsbyusingaLungCarta~(TM)kit.ThesensitivityandspecificityoftheproposedmethodwereevaluatedbydirectlysequencingEGFRandKRASgenesin100lungcancercases.Results:Theproposedmethodwasabletodetectmultiplexgeneticmutationsinlungcancercelllines.Thisfindingwasconsistentwiththeobservationsonpreviouslyreportedmutations.Theproposedmethodcanalsodetectsuchmutationsinclinicallungcancerspecimens.ThisresultwasconsistentwiththeobservationswithLungCarta~(TM)kit.However,anFGFR2mutationwasdetectedonlythroughtheproposedmethod.Themeasuredsensitivityandspecificitywere100%and96.3%,respectively.Conclusions:TheproposedMassARRAYtechnology-basedmultiplexmethodcandetectgeneticmutationsinChineselungcancerpatients.Therefore,theproposedmethodcanbeappliedtodetectmutationsinothercancertissues.

简介：在这份报纸，分析了是在直角的频率分割的标志同步算法复合(OFDM)系统，并且完成是粗糙、精致的同步算法的硬件电路设计。基于粗糙、精致的同步算法的分析，多路，模块累加器，部门和输出判断，它能显然保存硬件资源费用。电路顺序和设计计划的波浪表格模拟的分析证明建议方法高效地减少系统资源和电源消费。

简介：Thesymmetryenergy,whichgovernsmanyphysicalphenomenafromthestructureofexoticnucleitoastrophysicalprocesses,hasmanyramificationsinbothnuclearphysicsandastrophysics.Althoughnuclearsymmetryenergyanditsslopeatthenormaldensityofnuclearmatterhavebeenroughlypinneddown,recentinterpretationsofFOPIandFOPI-LANDdatabydifferenttransportmodelsleadtodivergentconclusionsonthedensity-dependentsymmetryenergyatsupradensities.

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简介：Thephotoacoustictomographybyusingthehandheldprobehasagreatpotentialinclinicalbreastimaging.However,theshapeoftheprobelimitsthechoiceoflightdeliveryinthissetup.Inthisletter,westudytwocommonlyusedilluminationtypesforhandheldprobe:bright-fieldilluminationanddark-fieldillumination.Ourresultsdemonstrateseveralparametershaveimportantimpactonthephotonfluenceindeepbreasttissue.Theresultswillhelptooptimizethedesignofthephotoacousticbreastimagingsystemwithahandheldprobe.

简介：Theopticalnoninvasivediagnosticofcharacteristicofsiliconsemiconductorde-vicesbyusingaInGaAsP/InPsemiconductorlaserasanopticalprobeisreported.Theprinci-pleofexperimentalmethodisbasedonthedependenceoftheopticalrefractiveindexonthecarrierchargedensityintheactiveregionofdevicesanddetectionofvariationofrefractiveindexbytwolaserbeaminterferometrictechniques.

简介：为了在压缩机的流动地上探索机翼探查试管和它的款项位置的效果，串联，并且发现机制怎么机翼探查影响压缩机串联的空气动力学的特征，这份报纸在一样的压缩机串联上执行了数字、试验性的工作。实验主要集中了于低马赫数字的案例(妈=0.1)，并且有不同马赫数字的案例(0.1，0.3，0.7)并且不同发生角度(-5,0，5)被数字方法调查。没有机翼探查试管的案例作为基线，和另外的三个案例被引用，机翼探查试管在不同chordwise位置安装了(30%，50%，70%弦长度)被学习。机翼探查试管的直径是3mm，它根据几何类似原则作为某特别机翼探查的300%扩大被设置。结果证明机翼探查试管根本在串联的流动能力上有否定影响调查点。分离和在压力方面上由机翼探查试管导致了的大规模streamwise旋涡在高马赫数字引起大多数损失。在压力方面表面的附近的流动领域上的机翼探查试管的影响是在低马赫数字的本地分离。机翼探查试管也有一清楚地在漏流动上完成。它减少漏流动的集体流动并且削弱漏旋涡的紧张，但是扩大影响区域。试管在chordwise位置通常是的一半被安装的盒子的全部的压力损失特别在高马赫数字比另外的盒子降低，它能甚至减少损失与基本盒子相比。

简介：这篇文章学习交流电领域测量(ACFM)的申请在缺点察觉为的方法在水下结构。ACFM系统的数字模型在海水环境为结构表面缺点察觉被造。有限元素模拟被执行在背叛区域调查电磁的信号分发的规则和特征。关于模拟结果，在水下人工的裂缝察觉实验为ACFM系统被设计并且进行。ACFM系统能检测的实验结果表演裂开在在水下组织，察觉精确性比85%高。这能满足设计要求在水下结构缺点察觉。在这篇文章的结果能被使用为基于的ACFM的优化和开发建立技术基础在水下结构缺点察觉系统。

简介：HL-2Atokamakisafusionresearchdevicewithdouble-nulldivertom.Itprovidesbetterexperimentalconditionstoinvestigateedegplasmafeatures,suchasconfinementperformance,particleandimpuritybehaviour,powerdepositionandmaterialerosion.Particularly,impurityproductionandtransportduetoplasmasurfaceinteractionmaybeeffectivelycontrolledbythedivertor.

简介：Cerenkovwakeamplificationcanbeusedasanacceleratingscheme,inwhichatriggerbunchofelectronspropagatinginsideacylindricalwaveguidefilledwithanactivemediumgeneratesaninitialwakefield.Duetothemultiplereflectionsinsidethewaveguide,thewakemaybeamplifiedsignificantlymorestronglythanwhenpropagatinginaboundlessmedium.Sufficientlyfarawayfromthetriggerbunchthewake,whichtravelswiththesamephasevelocityasthebunch,reachessaturationanditcanaccelerateasecondbunchofelectronstrailingbehind.ForaCO2gasmixtureournumericalandanalyticalcalculationsindicatethatashortsaturationlengthandahighgradientcanbeachievedwithalargewaveguideradiusfilledwithahighdensityofexcitedatomsandatriggerbunchthattravelsatavelocityslightlyabovetheCerenkovvelocity.Toobtainastablelevelofsaturatedwakethatwillbesuitableforparticleacceleration,itiscrucialtosatisfythesingle-moderesonancecondition,whichrequireshighaccuracyinthewaveguideradiusandtheratiobetweentheelectronphasevelocityandtheCerenkovvelocity.Forsingle-modepropagationourmodelindicatesthatitisfeasibletoobtaingradientsashighasGVm-1inawaveguidelengthofcm.

简介：在这份报纸，扩大因素ks偷看有在在山东省上的班和地点上的不同exceedance概率的地面运动被分析从班地点的358地上凿穿和班的140地上凿穿收集的土壤层的地震反应数据估计地点。从结果，一个人能结束那1ks的scatter阴谋通常服从正常分布；有输入地面的力量的增加的2ks减少打手势，它比在班lI地点在班地点是更明显的；3随磨擦运动输入的基岩接口的深度的增加，为类地点，ks逐渐地增加直到到稳定的值深度什么时候到达直到约20米或更大。然而为班地点，ks对深度感觉迟钝；4为班地点的ks的一般水准是1.47，比在中国GB18306-2001的地震地面运动参数带状配列地图使用了那稍微大。另外，在在在山东省上的山峰地面加速的不同层次的班和地点上的kspreliminarily在纸被讨论。

简介：ThisworkfocusesonstochasticLi′enardequationswithstate-dependentswitching.First,theexistenceanduniquenessofastrongsolutionareobtainedbysuccessiveconstructionmethod.Next,strongFellerpropertyisprovedbyintroducingcertainauxiliaryprocessesandusingtheRadon-Nikodymderivativesandtruncationarguments.Basedontheseresults,positiveHarrisrecurrenceandexponentialergodicityareobtainedundertheFoster-Lyapunovdriftconditions.Finally,examplesusingvanderPolequationsarepresentedforillustrations,andthecorrespondingFoster-Lyapunovfunctionsfortheexamplesareconstructedexplicitly.

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