简介：摘要目的探讨免疫吸附治疗ANCA相关性血管炎（AAV）患者的临床效果与护理。方法纳入2010年5月至2017年10月在我科明确诊断为AAV伴有肾脏损害的患者,对比治疗前后的抗体滴度、伯明翰血管炎评分，记录并发症，统计免疫吸附治疗后1月的脱离透析率。结果11例患者均为重症AAV患者，治疗后1月,脱离透析率为63.6%,MPO-ANCA水平明显下降(p值=0.015)，BVAS评分明显下降(p值=0.001)。结论重症AAV患者通过免疫吸附治疗也可以获得较高的脱离透析率，在血浆缺乏的情况下，可以有效控制病情。

简介：

简介：

简介：E26transformation-specific-1(ETS-1)，一个et家庭抄写因素，被报导了在前列腺癌症(PCa)在ETS-1表示的许多生理、病理学的过程，而是临床的含意起一个重要作用，特别地高风险的案例，包括对雄激素剥夺的反应，治疗(ADT)还得被阐明。我们用针活体检视从69个主要先进的PCa病人获得的嵌入石蜡的前列腺癌织物染色的immunohistochemical检验了ETS-1的表示。ETS-1表示与69个病人的clinicopathological特征相比，包括25作为主要治疗经历了ADT。作为结果，有ETS-1的更高的表示的PCa病人是显著地，可能舞台高的更多得分(P<；0.05)。在ETS-1表示和起始的前列腺特定的抗原(PSA)水平之间没有重要协会。在ADT对待的25个病人，为ETS-1的染色的分数显著地在24个月以内与阉割抵抗的疾病的快速的开发被联系(P<；0.05)，而格利森分数和PSA水平不是。在结论，增加了ETS-1表示与到阉割抵抗的前进的一个更高的阶段，更高级的格利森分数和更短的时间被联系。这些数据建议为ETS-1的immunostaining能是为为PCa病人预言差的临床的结果的一个分子的标记，特别地那些与高风险的疾病。

简介：AbstractMucormycosis is a lethal human disease caused by fungi of the order Mucorales. Mucormycosis is caused by fungi mainly belonging to the genera Mucor, Rhizopus, and Lichtheimia, all of which belong to the order Mucorales. The number of individuals with mucormycosis-causing disorders has increased in recent years, hence, leading to the spread of mucormycosis. Throughout the coronavirus disease 2019 (COVID-19) pandemic, numerous cases of mucormycosis in COVID-19-infected patients have been reported worldwide, and the illness is now recognized as COVID-19-associated mucormycosis, with most of the cases being reported from India. Immunocompromised patients such as those with bone marrow sickness and uncontrolled diabetes are at a greater risk of developing mucormycosis. Genes, pathways, and other mechanisms have been studied in Mucorales, demonstrating a direct link between virulence and prospective therapeutic and diagnostic targets. This review discusses several proteins such as high-affinity iron permease (FTR1), calcineurin, spore coat protein (CotH), and ADP-ribosylation factors involved in the pathogenesis of mucormycosis that might prove to be viable target(s) for the development of novel diagnostic and therapeutic methods.

简介：AsubalgebraofloopalgebraA2isestablished.Therefore,anewisospectralproblemisdesigned.BymakinguseofTu''sscheme,anewintegrablesystemisobtained,whichpossessesbi-Hamiltonianstructure.Asitsreductions,aformalismsimilartothewell-knownAblowitz-Kaup-Newell-Segur(AKNS)hierarchyandageneralizedstandardformoftheSchrodingerequationarepresented.Inaddition,inorderforakindofexpandingintegrablesystemtobeobtained,aproperalgebraictransformationissuppliedtochangeloopalgebraA2intoloopalgebraA1.Furthermore,ahigh-dimensionalloopalgebraisconstructed,whichisdifferentfromanypreviousone.Anintegrablecouplingofthesystemobtainedisgiven.Finally,theHamiltonianformofabinarysymmetricconstrainedflowofthesystemobtainedispresented.

简介：Protein-proteininteractions(PPIs)havebeenwidelystudiedtounderstandthebiologicalprocessesormolecularfunctionsassociatedwithdifferentdiseasesystemslikecancer.Whilefocusedstudiesonindividualcancershavegeneratedvaluableinformation,globalandcomparativeanalysisofdatasetsfromdifferentcancertypeshasnotbeendone.Inthiswork,wecarriedoutbioinformaticanalysisofPPIscorrespondingtodifferentiallyexpressedgenesfrommicroarraysofvarioustumortissues(belongingtobladder,colon,kidneyandthyroidcancers)andcomparedtheirassociatedbiologicalprocessesandmolecularfunctions(basedonGeneOntologyterms).Weidentifiedasetofprocessesorfunctionsthatarecommontoallthesecancers,aswellasthosethatarespecifictoonlyoneorpartialcancertypes.Similarly,proteininteractionnetworksinnucleicacidmetabolismwerecomparedtoidentifythecommon/specificclustersofproteinsacrossdifferentcancertypes.Ourresultsprovideabasisforfurtherexperimentalinvestigationstostudyproteininteractionnetworksassociatedwithcancer.Themethodologydevelopedinthisworkcanalsobeappliedtostudysimilardiseasesystems.

简介：

简介：Inordertoprovideanoperationalreferencefortropicalcycloneprecipitationforecast,thisstudyinvestigatesthespatialdistributionsofprecipitationassociatedwithlandfallingtropicalcyclones(TCs)affectingChinausingGeostationaryMeteorologicalSatellite5(GMS5)-TBBdataset.AllnamedTCsformedoverthewesternNorthPacificthatmadedirectlandfalloverChinaduringtheperiod2001-2009areincludedinthisstudy.BasedontheGMS5-TBBdata,thispaperrevealsthatingeneraltherearefourtypesofdistributionofprecipitationrelatedtolandfallingTCsaffectingChina.(a)theSouth-WestTypeinwhichthereisaprecipitationmaximumtothesouthwesternquadrantofTC;(b)theSymmetricalSouthTypeinwhichtherainfallismorepronouncedtothesouthsideofTCintheinnercorewhilethereisasymmetricalrainfalldistributionintheouterbandregion;(c)theSouthType,inwhichtherainfallmaximaismorepronouncedtothesouthofTC;and(d)theNorthType,inwhichtherainfallmaximaismorepronouncedtothenorthofTC.AnalysesoftherelationshipbetweenprecipitationdistributionsandintensityoflandfallingTCsshowthatforintensifyingTCs,boththemaximumandthecoverageareaoftheprecipitationinTCsincreasewiththeincreaseofTCintensityovernorthernJiangsuprovinceandsouthernTaiwanStrait,whiledecreasingoverBeibuGulfandtheseaareaofChangjiangRiverestuary.ForallTCs,thecenterofthetorrentialraininTCshiftstowardtheTCcenterastheintensityofTCincreases.Thisfindingisconsistentwithmanypreviousstudies.Thepossibleinfluencesofstormmotionandverticalwindshearontheobservedprecipitationasymmetriesarealsoexamined.Resultsshowthattheenvironmentalverticalwindshearisanimportantfactorcontributingtothelargedownshearrainfallasymmetry,especiallywhenaTCmakeslandfallonthesouthandeastChinacoasts.Theseresultsarealsoconsistentwithpreviousobservationalandnumericalstudies.

简介：Inthispaper,weobtaintheinvarianceprincipleforlinearprocessesgeneratedbyanegativelyassociatedsequence.

简介：ＡＲｅｓｅａｒｃｈＩｎｓｔｉｔｕｔｅｏｆＳｕｒｇｅｒｙ，ＤａｐｉｎｇＨｏｓｐｉｔａｌ，ＴｈｉｒｄＭｉｌｉｔａｒｙＭｅｄｉｃａｌＵｎｉｖｅｒｓｉｔｙ，Ｃｈｏｎｇｑｉｎｇ４０００４２，Ｃｈｉｎａ（ＬｉｕＬＭ，ＣｈｅｎＨＳ，ＨｕＤＹ，ＬｕＲＱ，ＣｈｅｎＹ...

简介：Oceanicgeneralcirculationmodelshavebecomeanimportanttoolforthestudyofmarinestatusandchange.ThispaperreportsanumericalsimulationcarriedoutusingLICOM2.0andtheforcingfieldfromCORE.WhencomparedwithSODAreanalysisdataandERSST.v3bdata,thepatternsandvariabilityofthetropicalPacific–IndianOceanassociatedmode(PIOAM)arereproducedverywellinthisexperiment.Thisindicatesthat,whenthetropicalcentral–westernIndianOceanandcentral–easternPacificareabnormallywarmer/colder,thetropicaleasternIndianOceanandwesternPacificarecorrespondinglycolder/warmer.ThisfurtherconfirmsthatthetropicalPIOAMisanimportantmodethatisnotonlysignificantintheSSTanomalyfield,butalsomoreobviouslyinthesubsurfaceoceantemperatureanomalyfield.Thesurfaceassociatedmodeindex(SAMI)andthethermocline(i.e.,subsurface)associatedmodeindex(TAMI)calculatedusingthemodeloutputdataarebothconsistentwiththevaluesoftheseindicesderivedfromobservationandreanalysisdata.However,themodelSAMIandTAMIaremorecloselyandsynchronouslyrelatedtoeachother.

简介：LetL=-?+VbeaSchrdingeroperatoractingonL2(Rn),n≥1,whereV≡0isanonnegativelocallyintegrablefunctiononRn.Inthisarticle,wewillintropduceweightedHardyspacesHL(w)associatedwithLbymeansofthesquarefunctionandthenstudytheiratomicdecompositiontheory.WewillalsoshowthattheRiesztransform?L-1/2associatedwithLisboundedfromournewspaceHpL(w)totheclassicalweightedHardyspaceHp(w)whenn/(n+1)

简介：Theaggregationbehaviorandstructureofhydrophobicallymodifiedblockcopolymersofacrylamideand2-phenoxylethylacrylatewereinvestigatedbyviscometry,1HNMRrelaxation,2DNOESY,fluorescenceanddynamiclightscattering.Itwasfoundthattheaggregationbehaviorwasstronglydependentontheconcentrationofpolymersolutionandthehydrophobecontents.Withvaryingconcentrationfrom2.0,6.0,8.0to12.0g/L,thereweredifferentaggregatemorphologiesdistributedinaqueoussolutions,suchasmonopolymerchain,micelle-likeaggregate,multi-micelleaggregateandcross-linkednetwork.Accordingtothemodelofaggregation,itcangiveareasonableexplanationonthelargemagnitudeenhancementofviscositywiththeincreasingofpolymerconcentration.Additionaldataof2DNOESYandfluorescenceshowthatthecopolymerwithhigherhydrophobecontent(molarfraction≥1%)islikelytoformintra-molecularassociation.

简介：AbstractBackground:Recent studies suggest that a healthy diet helps to prevent the development of Alzheimer disease (AD). This study aimed to investigate whether spicy food consumption is associated with cognition and cerebrospinal fluid (CSF) biomarkers of AD in the Chinese population.Methods:We enrolled 55 AD patients and 55 age- and gender-matched cognitively normal (CN) subjects in a case-control study, as well as a cohort of 131 participants without subjective cognitive decline (non-AD) in a cross-sectional study. Spicy food consumption was assessed using the Food Frequency Questionnaire (FFQ). Associations of FFQ scores with cognition and CSF biomarkers of AD were analyzed.Results:In the case-control study, spicy food consumption was lower in AD patients than that in CNs (4.0 [4.0-8.0] vs. 8.0 [4.5-10.0], P < 0.001); FFQ scores were positively associated with Mini-Mental Status Examination scores in the total sample (r = 0.218, P = 0.014). In the cross-sectional study, the association between spicy food consumption and cognition levels was verified in non-AD subjects (r = 0.264, P = 0.0023). Moreover, higher FFQ scores were significantly associated with higher β-Amyloid (1-42) (Aβ42) levels and lower phospho-tau/Aβ42 and total tau/Aβ42 ratios in the CSF of non-AD subjects (P < 0.05).Conclusion:Spicy food consumption is closely related to higher cognition levels and reversed AD biomarkers in the CSF, suggesting that a capsaicin-rich diet might have the potential to modify the cognitive status and cerebral pathologies associated with AD.

简介：

简介：

简介：Inthispaper,weestablishtheLp(Rn+1)boundednessforthecommutatorsofsingularintegralsassociatedtosurfacesofrevolution,{(t,φ(|t|)):t∈Rn},withroughkernels?∈L(logL)2(Sn-1),ifφ(|t|)=|t|.

简介：为上海，在更早的时间有强烈Mei-yu降雨样品above500公里和许多研究的很少记录。为这篇论文是可得到的的，仅仅是初步的结果。(1)在严重Mei-yu季节期间，西北太平洋，上的140°E向西没有TC使副热带的高山脉和Mei-yu前面能稳定在上沿着时间并且在季节期间引起更多的降水。标记Mei-yu的开始和结束的TC在季节的发作和结束起了一个关键作用。(2)向北方，在Mei-yu的发作前的运动ofTCs使副热带的高度能有一重要跳，它为Mei-yu的日期用作好指示物发作。(3)西的环粮数的紧张与Mei-yu降雨的大小被联系。当这个索引增加了时，集中的降雨发生了。(4)为强烈Mei-yu的年，副热带的高度的山脉线比平均年向北方更在1和4纬度之间。降雨与副热带的高度的茶碱紧张被联系，偏午，由管理他们的相互作用在发生了的系统和地点的稳定的控制的持续时间。

简介：Inthecontextoftopcolor-assistedtechnicolor(TC2)model,westudythechargedandneutraltop-pionsproductionprocessγγ→W~+П_t~-П_t~0.Wefindthattheproductioncrosssectionislargerthanthatoftheprocessγγ→W~+H~-Hintheminimalsupersymmetricstandardmodel.WithreasonablevaluesoftheparametersintheTC2model,thecrosssectioncanreachthelevelofafewfb.Furthermore,theflavor-changing(FC)decaymodeП_t~0→tcisthebestchanneltodetecttheneutraltop-pionduetothecleanSMbackground.Withalargenumberofeventsandthecleanbackground,theneutraltop-pionshouldbeobservableatfuturelinearcollidersoperatinginγγmodeattheTeVenergyscale.