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简介:Inthisarticleweintroducethevectorvaluedsequencespacem(Eκ,φ,A),associatedwiththemultipliersequenceA=(λκ)ofnon-zerocomplexnumbers,andthetermsofthesequencearechosenfromtheseminormedspacesEκ,seminormedbyfκforallkεN.Thisgeneralizesthesequencespacere(φ)introducedandstudiedbySargent.Westudysomeofitspropertieslikesolidity,completeness,andobtainsomeinclusionresults.Wealsocharacterizethemultiplierproblemandobtainthecorrespondingspacesdualtom(Eκ,φ,A).Weprovesomegeneralresultstoo.
简介:摘要目的比较分析不同方法学之间ANCA相关性血管炎检测结果。方法来自2013年至2014年临床怀疑小血管炎的患者248例,应用间接免疫荧光法(IIF)、免疫印迹法(LIA)、抗原特异性EIA(MPO、PR3)3中方法进行检测。结果IIFA法阳性率为5.6%(14/248),LIA法阳性率为5.2%(13/248);EIA法阳性率为6.0%(15/248);IIFA法检出阳性14例,敏感性为92.3%(12/13);LIA法检出阳性13例,敏感性为92.3%(12/13);EIA法检出阳性15例,敏感性为100%(13/13);结论三种方法学间检出率有所差异,实验室应该结合三种方法同时进行,避免血管炎漏检。
简介:原发性小血管炎伴或不伴抗中性粒细胞胞浆抗体(ANCA)阳性,临床上常出现多系统受损。我国环核型ANCA(pANCA)相关小血管炎较多见,肾脏损害严重,预后差。在肾活检没有普及的基层医院,其最主要的诊断依据是血清ANCA检测结果,误诊率较高。现将我院近8年收治的9例pANCA相关小血管炎所致急性肾衰竭患者的临床资料总结如下。
简介:血管炎是一组以血管壁的炎症和纤维素样坏死为主要病理特征的系统性疾病。抗中性粒细胞胞浆抗体(ANCA)相关小血管炎包括韦格纳肉芽肿(Wegener'sgranulomatosis,WG)、显微镜下型多血管炎(microscopicpolyangiitis,MPA)和Churg—Strauss综合征(CSS)和局灶节段坏死性肾炎。ANCA是其血清学标志,它是一种以中性粒细胞和单核细胞胞浆成分为靶抗原的自身抗体。间接免疫荧光法(IIF)可将ANCA分为二种荧光类型:胞浆型(c-ANCA)和环核型(p—ANCA),前者的特异性靶抗原为蛋白酶3(PR3);后者特异性靶抗原之一为髓过氧化物酶(MPO)。
简介:Bytakingtheurbangreenlandastestingobjective,theGeoEye-1fusionimageasbackground,andusingMoran’sindex,thecorrelativityofgreenlandunitshasbeenmeasured.Then,thepresamplingwasconductedbasedonthemeasuredcorrelativity,thesystematicsamplingdesignhasbeencarriedoutattheprecision95%and85%.ByusingofKriginginterpolationmethod,theweightofdifferenttypeofgreenlandhasbeendividedintothestratifications.Throughthestratifiedsampling,theestimationofgreenlandcoveragehasbeenobtained.Theresultsshowthattheurbangreenlandcoverageareais14.81km~2,accountingfor27.73%ofallurbanlandareas.Comparedwiththecommonsamplingmethod,theprecisionofthatincreasedabout3%.Thismethodcanalsobeutilizedinmonitoringdynamicvariationofurbangreenlandwiththerealtimeimages.
简介:公共天气服务是向向用户提供概率的天气预报的trending,代替传统的确定的预报。概率的预报技术不断地正在被改进优化可得到的预报信息。预报(BPF)的贝叶斯的处理器,为概率的预报的一个新统计方法,能根据在那个预报系统产生的观察和预报之间的历史的统计关系把一张确定的预报转变成一张概率的预报。这种技术在确定说明一个确定的预报系统的典型预报性能预报无常。meta-Gaussian可能性的模型对有单调可能性的比率的许多随机的依赖结构合适。收养这种可能性的模特儿的meta-GaussianBPF能因此越过许多地被使用,包括气象学和水文学。有二个连续随机的变量和正常线性的BPF的Bayes定理简短被介绍。为用一个单个预言者的连续predictand的meta-GaussianBPF然后被介绍并且讨论。meta-GaussianBPF的表演在一个初步的实验被测试。在在长沙和武汉车站的0000UTC的每日的表面温度的控制预报被用作确定的预报数据。这些控制预报从整体预言被拿,一96-h铅时间由中国气象学的管理的国家气象学的中心产生了,中等范围的天气的欧洲中心预报,并且US公民为在2008年1月期间的环境预言集中。实验的结果证明meta-GaussianBPF能从三整体预言中的任何一个把表面温度的一张确定的控制预报转变成表面温度的一张有用概率的预报。这些概率的预报确定控制预报的无常;因此,概率的预报的表演基于内在的确定的控制预报的来源不同。
简介:AbstractTuberous sclerosis complex (TSC) is a rare multisystem, autosomal dominant neurocutaneous syndrome in which epilepsy is the most common of several neurological and psychiatric manifestations. Around two thirds of patients develop drug-resistant epilepsy for whom surgical resection of epileptogenic foci is indicated when seizures remain inadequately controlled following trial of two antiseizure medications. The challenge with presurgical and surgical approaches with patients with TSC is overcoming the complexity from the number of tubers and the multiplex epileptogenic network forming the epileptogenic zone. Data suggest that seizure freedom is achieved by 55%-60% of patients, but predictive factors for success have remained elusive, which makes for unconfident selection of surgical candidates. This article presents three different cases as illustrations of the potential challenges faced when assessing the suitability of TSC patients for epilepsy surgery.
简介:AbstractBackground:Keloids are benign fibrous growths that are caused by excessive tissue build-up. Severe keloids exert more significant effects on patients’ quality of life than do mild keloids. We aimed to identify factors associated with the progression from mild keloids to severe keloids, as distinct from those associated with the formation of keloids.Methods:In this retrospective case-control study, 251 patients diagnosed with keloids at West China Hospital between November 2018 and April 2021 were grouped according to the severity of lesions (mild [n = 162] or severe [n = 89]). We collected their basic characteristics, living habits, incomes, comorbidities, and keloid characteristics from Electronic Medical Records in the hospital and the patients’ interviews. Conditional multivariable regression was performed to identify the independent risk factors for the progression of keloids.Results:Eighty-nine patients (35.5%) were classified as having severe keloids. We found the distribution of severe keloids varied with sex, age, excessive scrubbing of keloids, family income, the comorbidity of rheumatism, disease duration, characteristics of the location, location in sites of high-stretch tension, the severity and frequency of pain, the severity of pruritus, and infection. Multivariable analysis revealed significant associations between severe keloids and infection (odds ratio [OR], 3.55; P = 0.005), excessive scrubbing of keloids (OR, 8.65; P = 0.001), low or middle family income (OR, 13.44; P = 0.021), comorbidity of rheumatism (OR, 18.97; P = 0.021), multiple keloids located at multiple sites (OR, 3.18; P = 0.033), and disease duration >15 years (OR, 2.98; P = 0.046).Conclusion:Doctors should implement more active and thorough measures to minimize the progression of mild keloids in patients who have any of the following risk factors: infection, excessive scrubbing of keloids, low or middle family income, comorbidity of rheumatism, multiple keloids located at multiple sites, and disease duration >15 years.
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简介:让L是L上的一个分析的半组的无穷小的发电机[2]([n])与它的热核上的合适的上面的界限。假设L有围住的holomorphicL上的功能的演算[2]([n])。在这篇论文,我们定义与L联系在上的Littlewood-Paleyg功能[n]×[n],由GL(f)表示了(x1,x2),;定义区域功能,由SL(f)表示了(x1,x2)。用考尔德ón-Zygmund分解的一个珍视向量的版本,我们为1
简介:在精子房间的膜修正在精子capacitation代表关键步;然而,这些修正的分子的基础充分没被理解。Ezrin是ezrin/radixin/merlin家庭的学习最好的成员。作为在外皮的细胞骨架和血浆膜蛋白质之间的cross-linker,ezrin贡献膜表面结构改变。而且,激活ezrin和Rho分离禁止者,RhoGDI,通过Rho激活支持外皮的cytoskeleton-polymerized肌动朊的形成。因此,ezrin,肌动朊,RhoGDI,Rho和血浆膜蛋白质在vivo形成一个复杂网络,它贡献膜表面的结构的集会。以前,我们证明ezrin和RhoGDI1在人的睾丸被表示。因此,我们寻求了决定ezrin鈥揜hoGDI1鈥揳c听鈥搈embrane蛋白质网络是否在人的精子capacitation有一个角色。我们由西方的污点的结果显示ezrin被threonine567残余的phosphorylation在capacitation期间激活。Co-immunoprecipitation研究表明在精子capacitation期间,在ezrin和RhoGDI1之间的相互作用增加,并且二维的电气泳动胶化的phosphostaining证明RhoGDI1是phosphorylated,建议RhoGDI1从RhoA分裂并且导致精子头上的肌动朊聚合。我们推测那激活的ezrin在capacitation以后与polymerized肌动朊和glycosylated膜蛋白质cd44交往。用ezrin特定或肌动朊特定的monoclonal抗体堵住精子capacitation减少他们的acrosome反应(AR)率,但是没独自在AR上有效果。一起拿,我们的结果证明由ezrin,RhoGDI1,RhoA,F肌动朊和膜蛋白质组成的一个网络工作影响在人的精子capacitation期间发生在精子头的膜上的修正。
简介:作者调查Prandtl边界层理论能严厉地为被验证的边界层的一些例子。所有为与各种各样的Dirichlet边界条件(指定速度)装备的牛顿的液体与不可压缩的海军司烧方程他们被联系。这些例子包括一个家庭(非线性的3D)飞机平行流动,一个家庭(非线性)有在边界的一致注射和吸的平行管子流动,以及流动。我们也在建立Prandtl类型理论的有效性识别关键成分,即,一光谱海军司烧系统的近似答案上的限制由联合Prandtl类型系统的inviscid答案和解决方案构造了。这是除与Prandtl类型系统的well-posedness有关的著名问题以外的一个另外的困难。看起来主要阻塞到确认光谱限制状况是边界层的可能的分离。这些例子的一个普通主题也经由在边界压制速度正常到边界或由注射和吸以便是边界层的分离的抑制光谱限制能被验证。一条元定理然后被介绍它盖住这里考虑的所有盒子。
简介:现在的学习瞄准了估计与海洋的海绵联系的细菌的antifouling活动。八细菌的紧张的一个总数从海绵Sigmadociasp的表面被孤立,他们,SS02,SS05和SS06对形成biofilm细菌显示出禁止的活动。这3紧张的摘录更加影响了生产形成biofilm的能力和粘附的细胞外的聚合物质细菌的紧张。除了圆盘散开试金,microalgal解决试金被执行,摘录与聚氨酯木头光泽混合了并且到不锈钢赠券上涂。紧张SS05的摘录显示出强壮的microalgal解决禁止的活动。紧张SS05基于它的16SrRNA基因作为杆菌仙影拳被识别。与海洋的无脊椎动物联系的细菌的紧张的代谢物答应被发展进环境友好的antifouling代理人。
简介:Aheavyrainfallassociatedwiththedeepeningofamonsoondepressionhappenedinthesummerof2005.Thisprocesswasfirstdiagnosticallyanalyzedandthe3Dstructureofthemonsoondepressionwasdiscussed,thenthisstructurewascomparedwiththoseofthemonsoondepressioninSouthAsiaandthelowvortexintheMeiyufront.TheresultsshowedthattheheavyrainfalldirectlyresultedfromamonsoondepressioninSouthChina,andthelarge-scaleenvironmentprovidedafavorablebackgroundforthedeepeningofthemonsoondepression.The3Dstructureofthemonsoondepressionwasasfollows.Inthehorizontaldirection,thereexistedaconvectivecloudbandtothesouthofthemonsoondepression,whichlayinaconvectivelyinstablearea,witharelativelystrongascendingmotioninthemidandlowlevelsofthetroposphere,andtheascendingmotionmatchedwellwithamoisttongue,aconvergencearea,andabandofpositivevorticityinthemidandlowlevelsofthetroposphere.Intheverticaldirection,thedepressionhadanobviouslycycloniccirculationinthemidandlowlevelsofthetroposphere,butnocirculationfromabove300hPa.Themonsoondepressioncorrespondedtoconvergenceandpositivevorticityinthelowlevels,buttodivergenceandnegativevorticityintheupperlevels.Theupwarddraftofthedepressioncouldreachtheupperlevelsofthetroposphereinthewestofthedepression,whilethedescendingmotionlayintheeast.Therewasalow-leveljettothesouthofthedepression,whiletheupper-leveljetwasnotobvious.Thedepressionwasverticallywarmintheupperlevelsandcoldinthelowlevels,andtheaxisofthedepressiontiltedsoutheastwardwithheight,whosecharacteristicsweredifferentnotonlyfromthemonsoondepressioninSouthAsiabutalsofromthelowvortexintheMeiyufront.
简介:组织缺氧可诱导的factor-1α;(HIF-1α;)在调整angiogenesis起一个重要作用,它为肿瘤生长和转移是必要的。HIF1A的基因变化(编码HIF-1α;)被显示了影响一个个人的危险性到许多人的肿瘤;然而,在在HIF1A单个核苷酸的多型性(SNP)和风险正在冲突的前列腺癌症(PCa)之间的协会上证实。我们genotyped在用TaqMan方法的HIF1A(rs11549465,rs11549467和rs2057482)的三潜在地功能的多型性并且在662 的盒子控制研究与PCa风险估计了他们的协会;在一张中国汉人口的PCa病人和716控制。与rs11549467GG遗传型相比,变体遗传型GA+;AA有显著地增加的PCa风险(调整机会比率(或)=1.70;95%;信心间隔(CI)=1.06-2.72),特别地在更老的病人之中(OR=2.01;95%;CI=1.05-3.86),吸烟者(OR=2.06;95%;CI=1.07-3.99),从未喝酒者(OR=2.16;95%;CI=1.20-3.86)并且没有癌症的家庭历史的病人(OR=1.71;95%;CI=1.02-2.89)。而且,有rs11549467变体遗传型的病人与一个更高级的格利森分数被联系(OR=2.14;95%;CI=1.22-3.75)。没有改变的PCa风险与rs11549465和rs2057482多型性被联系。然而,rs2057482和rs11549467的联合变体遗传型与增加的PCa风险被联系(OR=2.10;95%;在带三的题目或更多的风险等位基因之中的CI=1.23-3.57)。这些结果建议HIF1A多型性可以在中国汉人口影响PCa危险性和前进。