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简介：在这篇论文，我们在与下列PexiderizedJensen功能的方程联系的quasi-Banach代数学证明同形的概括Hyers-Ulam稳定性这被用于调查在quasi-Banach代数学之间的同形。概括Hyers-Ulam稳定性的概念从Rassia出现在他的纸的稳定性定理发源：在在Banach空格的线性印射的稳定性上，Proc。Amer。数学。Soc，72，297300(1978)。

简介：Let{Xi；i≥1}beastrictlystationarysequenceofassociatedrandomvariableswithmeanzeroandletσ^2=EX1^2+2∑j=2^∞EX1Xjwith0

简介：MakinguseofWrightoperatorweintroduceanewclassofcomplex-valuedharmonicfunctionswithrespecttosymmetricpointswhichareorientationpreserving,univalentandstarlike.Weobtaincoefficientconditions,extremepoints,distortionbounds,andconvexcombination.

简介：Objective:Gastriccancer(GC)isoneoftheleadingcausesofdeathinChinaandotherAsiancountries.Recently,gastricendoscopyhasbecomethemainapproachforGCscreening,buttheidentificationofhigh-riskindividualsremainsachallengeinGCscreeningprograms.Methods:Therewere7,302patientswithchronicgastritisinvolvedinthisstudy.Endoscopicexaminationswereperformed,andtheirdemographiccharacteristicsandlifestyledatawerecollected.EachpossibleassociatedfactorofGC/premalignantandprecursorlesionswasevaluatedbyunivariateandmultivariatelogisticregressions.Nomogramswereusedforvisualizationofthosemodels,andreceiveroperatingcharacteristic(ROC)curveanalysiswasusedtopresentthepredictiveaccuracy.Results:Wedetected8(0.11%)gastricadenocarcinomas,17(0.23%)dysplasiacases,14(0.19%)hyperplasiacases,52(0.71%)intestinalmetaplasiacases,217(2.97%)inflammatorylesions,141(1.93%)gastriculcers,10(0.14%)atrophicgastritiscases,1,365(18.69%)erosivegastritiscases,and5,957(81.58%)superficialgastritiscasesin7,302patients.Theage(P<0.001),gender(P=0.086),laborintensity(P=0.018)andleekfoodintake(P=0.143)wereidentifiedasindependentpredictivefactorsofGC/premalignantlesionspossibility.Thecorrespondingnomogramexhibitedanareaunderthecurve(AUC)[95%confidenceinterval(95%CI)]of0.82(0.74–0.89)forthemodelinggroupand0.80(0.75–0.85)forthevalidationgroup.Theage(P=0.002),gender(P=0.024),smoking(P=0.002)andleekfoodintake(P=0.039)wereindependentpredictivefactorsofprecursorlesionspossibility.ThecorrespondingnomogramexhibitedanAUC(95%CI)of0.62(0.60–0.65)forthemodelinggroupand0.61(0.59–0.63)forthevalidationgroup.Conclusions:WeidentifiedseveralpotentialassociatedfactorsandprovidedapreclinicalnomogramwiththepotentialtopredictthepossibilityofGC/premalignantandprecursorlesions.

简介：AIMToverifythevalidityoftheendoscopyguidelinesforpatientstakingwarfarinordirectoralanticoagulants(DOAC).METHODSWecollecteddatafrom218patientsreceivingoralanticoagulants(73DOACusers,145warfarinusers)and218patientsnotreceivinganyantithrombotics(age-andsexmatchedcontrols)whounderwentpolypectomy.(1)Weevaluatedpost-polypectomybleeding(PPB)riskinpatientsweassessedtherisksofPPBandthromboembolismbetweenthreeACmanagementmethods:DiscontinuingACwithheparinbridge(HPB)(endoscopyguidelinerecommendation),continuingAC,anddiscontinuingACwithoutHPB.RESULTSPPBratewassignificantlyhigherinwarfarinusersandDOACuserscomparedwithcontrols(13.7%and13.7%vs0.9%,P<0.001),butwasnotsignificantlydifferentbetweenrivaroxaban(13.2%),dabigatran(11.1%),andapixaban(13.3%)users.Twothromboemboliceventsoccurredinwarfarinusers,butnoneinDOACusers.Comparedwiththecontinuinganticoagulantgroup,thediscontinuinganticoagulantwithHPBgroup(guidelinerecommendation)hadahigherPPBrate(10.8%vs19.6%,P=0.087).ThesefindingsweresignificantlyevidentinwarfarinbutnotDOACusers.OnethromboticeventoccurredinthediscontinuinganticoagulantwithHPBgroupandthediscontinuinganticoagulantwithoutHPBgroup;noneoccurredinthecontinuinganticoagulantgroup.CONCLUSIONPPBriskwassimilarbetweenpatientstakingwarfarinandDOAC.Thromboembolismwasobservedinwarfarinusersonly.TheguidelinerecommendationsforHPBshouldbere-considered.

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简介：Objective:Oralsquamous-cellcarcinoma(OSCC)accountsfor>90%oforalcancersaffectingadultsmostlybetweenthefourthtoseventhdecadesoflife.ThemostcommonOSCCtreatmentisconcomitantchemoradiotherapy(CCRT)havingbothlocoregionalanddistantcontrol,butCCRThasacuteandchronictoxiceffectsonadjacentnormaltissue.ThisstudyaimedtodeterminethesideeffectsofCCRTontheoralmucosaandtocharacterizetheclinicopathologyoforallesionsinpatientswithOSCC.Methods:Thisdescriptive,cross-sectionalstudywascertifiedbytheEthicalReviewCommittee(UHS/Education/126-12/2728)oftheUniversityofHealthSciences,Lahore,Pakistan.OSSCpatients(n=81)withvarioushistologicalsubtypes,grades,andstageswererecruited,andfindingsontheiroralexaminationwererecorded.Thesepatientsreceived70,90,and119Gyofradiotherapydosagesincombinationwiththechemotherapydrugscisplatinand5-fluorouracil.DatawereanalyzedusingSPSS20.0.Results:ThemostcommonpresentationofOSCCwasanonhealingulcer(63%)involvingtongue(55.6%).Clinicalfindingsincludedmucositis(92.6%)andxerostomiaofmild,moderate,andseveredegreesin11.1%,46.9%,and35.8%cases,respectively.Ulcers(87.7%),palpablelymphnodes(64.2%),limitedmouthopening(64.2%)andfistula(40.7%)werealsoobserved.Infemales,theassociationofradiotherapydosagewithlimitedmouthopening,xerostomia,andhistologicalgradingwasstatisticallysignificant(P<0.05).Theassociationofchemotherapydrugswithxerostomia(P=0.003)wasalsostatisticallysignificant.Conclusions:CCRTinducedmucositis,xerostomia,andtrismusinpatientswithOSCC.

简介：Thesuddenoutbreakofsevereacuterespiratorysyndrome(SARS)in2002promptedtheestablishmentofaglobalscientificnetworksubsumingmostofthetraditionalrivalriesinthecompetitivefieldofvirology.WithinmonthsoftheSARSoutbreak,collaborativeworkrevealedtheidentityofthedisastrouspathogenasSARS-associatedcoronavirus(SARS-CoV).However,althoughtherapididentificationoftheagentrepresentedanimportantbreakthrough,ourunderstandingofthedeadlyvirusremainslimited.Detailedbiologicalknowledgeiscrucialforthedevelopmentofeffectivecountermeasures,diagnostictests,vaccinesandantiviraldrugsagainsttheSARS-CoV.ThisarticlereviewsthepresentstateofmolecularknowledgeaboutSARS-CoV,fromtheaspectsofcomparativegenomics,molecularbiologyofviralgenes,evolution,andepidemiology,anddescribesthediagnostictestsandtheanti-viraldrugsderivedsofarbasedontheavailablemolecularinformation.

简介：WhenbeingplantedinwideareasinsouthernChina(23°23'-33°23'N,98°35’-129°19'E,sealevelabove2.7-1285m),Liangyoupeijiu(LYPJ),atwo-linehybridricecombination,showedaseedsettingrateof75.2-77.2%,whichwaslowerby4.3-7.5percentpointthanthatofanindicahybridriceShanyou63(CK),withsimilarvaluesofgrainyieldandcoefficientsofvariationtoCK.Sowingduring5-25thofMayinNanjing(32°3'N.118°48'E),China,LYPJheadedbefore4thSeptember,andgaveaseedsettingrateof75-90%,andgrainyieldover1kg/m^2.Ifthesowingdatewasdelayedto14-15th,June,itsheadingdatewouldbeaslateas17th-21stSeptember,andseedsettingratewouldbedeclinedby10-15%incomparisonwiththatonasuitablesowingdate.Whenfloweringtookplaceatanaveragedailytemperaturerangeof13.7-28.5℃forfivedays,thespikeletfertility(SF)wouldbeincreasedby1.9-10.7%,foreachincrementof1℃.Thesuitable(SF≥90%)andsafe(SF≥75%)temperaturesforfloweringstagewereindicatedtobe26.5°and22.9°,respectively.TogetahighandstableseedsetincultivatingLYPJ,itwasrecommendedthatLYPJwouldbeplantedintheareassouthof34°N,andthefavorableaveragedailytemperatureduringfloweringstageshouldbeat26-28℃.

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简介：Recentstudieshaveshownthattheglycation-associateddamageisnotlimitedtopatientswithdiabetes.Becauseoftheirassociationwithoxidativestress,advancedglycationend-products(AGEs)havealsobeenimplicatedinmanyneurodegenerativediseases,suchasHuntingtondisease,amyotrophiclateralsclerosis,andAlzheimerdisease(Yanetal.,

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简介：Seasonalvariationsofphytoplankton/chlorophyll-a(Chl-a)distribution,seasurfacewind,seaheightanomaly,seasurfacetemperatureandotheroceanicenvironmentsforlongperiodsareanalyzedintheSouthChinaSea(SCS),especiallyinthetwotypicalregionsofftheeastcoastofVietnamandoffthenorthwestcoastofLuzon,usingremotesensingdataandotheroceanographicdata.TheresultsshowthatseasonalandspatialdistributionsofphytoplanktonbiomassintheSCSareprimarilyinfluencedbythemonsoonwindsandoceanicenvironments.OfftheeastcoastofVietnam,Chl-aconcentrationisapeakinAugust,ajetshapeextendingintotheinteriorSCS,whichisassociatedwithstrongsouthwesterlymonsoonwinds,thecoastalupwellinginducedbyoffshoreEkmantransportandthestrongoffshorecurrentinthewesternSCS.InDecember,highChl-aconcentrationappearsintheupwellingregionoffthenorthwestcoastofLuzonandspreadssouthwestward.Strongmixingbythestrongnortheasterlymonsoonwinds,thecycloniccirculation,southwestwardcoastalcurrentsandriverdischargehaveimpactsondistributionofphytoplankton,sothatthehighphytoplanktonbiomassextendsfromthecoastalareasoverthenorthernSCStotheentireSCSinwinter.TheseresearchactivitiescouldbeimportantforrevealingspatialandtemporalpatternsofphytoplanktonandtheirinteractionswithphysicalenvironmentsintheSCS.

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简介：Thisstudyfocusesonthedecadalvariabilityoftropicalcyclones(TC)overtheWesternNorthPacific(WNP)andhowthesechangesarerelatedtotheMadden-JulianOscillation(MJO).ItwasdonewiththehelpoftheReal-timeMultivariateMJOindexfromtheAustralianGovernmentBureauofMeteorologyoftheCentreforAustralianWeatherandClimateResearch,TCdatafromtheJointTyphoonWarmingCenterbesttrackdatasets,anddailyandmonthlydatasetsfromtheNCEP/NCARreanalysiscenter.TheresultsshowthattheTCfrequencyintheWNPexhibitedastatisticallysignificantdecreaseduring1998-2010comparedtoduring1979-1997.ThedecreaseinTCfrequencyintheWNPmainlyoccurredduringMJOactivephases(i.e.,phases4,5,6,and7).FurtherinvestigationoftheclimatebackgroundandthepropagationdifferencesoftheMJObetween1979-1997and1998-2010wasperformed.TheLaNina-liketropicalseasurfacetemperaturecoolingcausedstrongerWalkercirculationandthusinducedunfavorableatmosphereconditionsforWNPTCgenesisincludingalow-leveleasterlyanomaly,anegativerelativevorticityanomaly,anincreaseinsea-levelpressure,andstrongerverticalwindshear.Moreover,shorteningoftheMJOcycle,declineinthedurationoftheactivephasesintheWNP,andeasterlyanomalyandshrinkageoftheconvectionareaduringMJOactivephasesmayalsopartlyexplainthedecadalvariationofTC.

简介：有生气的层的想法的为无线传感器的存取控制(MAC)协议联网的媒介(WSN)的设计吸引越来越多的注意。人们能由关于网络层和物理层获得某些信息改进MAC协议。这篇文章综合并且优化存在的某些跨层的协议。根据路由，在网络层的拓扑学信息，和在物理层的传播力量信息，时间槽任务算法在MAC层被改进了。由使用地理适应忠实算法(GAF)划分格子，传播电源控制并且为传感器节点安排工作/睡觉责任周期，一个新MAC协议被建议了到减少精力消费并且扩大WSN的一生。模拟结果证明MAC协议工作很好。

简介：胆碱是在精子膜结构和流动性的规定的一个关键因素，并且这营养素在成熟和精子的使肥沃的能力起一个重要作用。phosphatidylethanolamineN-methyltransferase(PEMT)和胆碱脱氢酶(CHDH)的抄本，胆碱新陈代谢的二基本的酶，在人的睾丸被观察了，在这纸巾表明他们的基因表示。在现在的学习，我们探索了PEMT和CHDH基因变体的贡献到精子参数。200oligospermic和250个normozoospermic人被招募。DNA从精子，和PEMT−被提取；774G>；C和CHDH+；432G>；T多型性是genotyped。PEMT−的遗传型分发；774G>；C多型性没在oligospermic和normozoospermic人之间不同。相反，在CHDH+的情况中；432G>；T多型性，oligospermic人比normozoospermic人更经常介绍了CHDH432G/G遗传型(62%；对42%；，P<；0.001)。PEMT774G/G遗传型在oligospermic人与PEMT774G/C和774C/C遗传型相比与更高的精子集中被联系(12.5±；5.6×；106精子ml−1对8.3±；5.2×；106精子ml−1,P<；0.002)并且normozoospermic人(81.5±；55.6×；106对68.1±；44.5×；106精子ml−1,P<；0.006)。另外，CHDH432G/G遗传型在oligospermic与CHDH432G/T和432T/T遗传型相比与更高的精子集中被联系(11.8±；5.1×；106对7.8±；5.3×；106精子ml−1,P<；0.003)并且normozoospermic人(98.6±；62.2×；106对58.8±；33.6×；106精子ml−1,P<；0.001)。在我们的系列，PEMT−；774G>；C和CHDH+�

简介：Cancerevadeshostimmunesurveillancebyusingimmunecheckpoints,whichareinhibitorypathwayscrucialformaintainingself-tolerance1.Tumorcellsexpressmultipleinhibitoryligands,andtumor-infiltratinglymphocytes(TIL)expressavarietyofinhibitoryreceptors.InhibitoryreceptorscytotoxicT-lymphocyte-associatedprotein4(CTLA-4)andprogrammeddeath-1

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