简介:摘要在英语教学过程中,与学生关系最为密切的就是英语教师。处在成长期中的高中学,无论是学识水平、人生阅历,还是情感价值观都存在着局限性,要想促进他们全方位地健康发展,这就需要英语教师发挥其教育、示范、指导作用。但是,作为学习主体和教学对象的学生是活生生的有思维,有情感的个体,要想让教师对他们产生最积极、最有效的影响,笔者认为只有那些真正有魅力的英语教师才能做到。所谓魅力,是指人有很强的吸引力和诱惑力。古人云“亲其师,信其道,爱其业。”笔者试图从personality(个性魅力),profession(学识魅力)和performer(角色魅力)这三个方面浅要谈谈魅力英语教师的修炼。
简介:AbstractPurpose:The pathogenesis of gastrinomas is largely unknown, and there is a lack of reliable genetic determinants that are useful to distinguish malignant and benign forms of this tumor or predict the prognosis of patients with this disease. Loss of heterozygosity (LOH) on chromosome 3p is reported to occur in pancreatic neuroendocrine tumors (PNETs) as well as in non-PNETs and its presence is reported to correlate with tumor prognosis in non-endocrine tumors. However, little data are available from prospective studies on gastrinomas.Experimental design:We assessed occurrence of 3p LOH in 24 gastrinomas and correlated its presence with tumor biological behavior and other clinicopathological features of gastrinomas.Results:Either 3p LOH or microsatellite instability involving 3p occurred in 11 of 24 tumors (46%). Seven (29%) gastrinomas had 3p LOH. Of the 7 gastrinomas with 3p LOH, 5 (71%) had 3p12 LOH with the marker D3S2406, which was the shortest region of highest overlap (SRO). Chromosome 3p LOH was not associated with aggressive biological behavior of gastrinomas or with poor prognosis of patients with gastrinoma. Similarly, 3p12 LOH (SRO) was not correlated with aggressive growth of tumors and/or liver metastases.Conclusion:Gastrinomas have a relative high frequency of 3p12 LOH suggesting this area may harbor putative tumor suppressor gene(s), which may play a role in the tumorigenesis, but not aggressiveness, of a subset of these tumors.
简介:摘要:3P教学法起源于交际教学法,可操作性强。本文旨在结合实例,探索3P教学法在高中英语语法教学中的具体实施操作办法。
简介:应用国际SPE-PRMS准则评估3P储量时,存在含油面积确定依据不明确的问题。综合运用测井、试井和试油等资料及油气藏特点,结合国际合作区块3P储量评估结果,对SPE-PRMS准则下不同类型油藏的3P储量含油气边界确定方法进行了研究。结果表明:在该准则下,根据油藏类型来确定含油面积的评估方法可进一步提高储量评估结果的可信度,并能有效降低油气开发生产的风险。
简介:摘要目的探讨2例3p缺失综合征患者的临床表型及遗传学特点。方法选取分别于2021年11月、2020年10月至浙江大学医学院附属妇产科医院生殖遗传门诊就诊的2例3p缺失综合征患者为研究对象,其中患者1为胎儿。收集二者的临床资料,采集患者1母亲的羊水样本30 mL,患者2的外周血样5 mL,进行G显带染色体核型分析和单核苷酸多态性微阵列芯片(SNP-array)检测。结果患者1主要临床表现为左侧胸腔积液,患者2表现为智力低下、原发不孕。二者G显带染色体核型分别为46,XY,del(3)(p25)和46,XX,del(3)(p25)。SNP-array显示其均在3p26.3p25.3区存在杂合缺失,缺失片段分别为9 369 kb和9 404 kb,且均涉及CNTN4、CNTN6、OXTR、CHL1和SRGAP3等21个OMIM基因,患者2的缺失还涉及SETD5基因。患者1父母经遗传咨询后选择了终止妊娠。结论本研究确诊了2例3p缺失综合征患者,3p26.3p25.3杂合缺失可能为其临床表型的遗传学病因。上述发现丰富了该综合征的临床表型谱。
简介:【摘要】英语教学的3P教学法已经广泛的应用于我国各个阶段的英语语法教学之中。众所周知,3P教学的方法是从其他国家的教学方式中演变而来的,要想更好的利用这个方法进行英语语法学习,就需要老师对这个方法先进行分析和学习,再利用这个方法对学生进行具体的知识内容讲授。所谓的3P教学法就主要是Presentation呈现、Practice练习和Production 输出,通过这三个部分的讲授,老师可以帮助学生从新学的课文内容之中了解新的知识,也能够让学生弄清楚课堂知识的重点。