简介：neovascularization的形成是许多眼睛的脉管的疾病的一个普通病理学的特征，并且是在病人的视觉损失的一个重要原因。Neovascularization能引起网膜的出血，玻璃的出血，和另外的严肃的复杂并发症，导致视觉的损失。intraocularneovascularization的治疗是眼科学研究的焦点。在最近的年里，一些研究发现了autophagy是仔细与脉管的endothelial生长因素和neovascularization的形成有关。Autophagy被期望为intraocularneovascularization的治疗成为一个新目标。因此，这篇文章在autophagy和intraocularneovascularization的形成上考察研究。

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简介：Thispaperdealswiththeissueofprioritysettinginhealthcareunderuncertaintiesabouttheseverityoftheillnessandtheeffectivenessofmedicaltreatment.Weexaminetheeffectofadiseaseuncertainty(atreatmentuncertainty)ontheallocationofhealthcareresourcesinthepresenceofatreatmentrisk(adiseaserisk)andidentifypreferenceconditionsunderwhichthesocialplannerallocatesmoreresourcestohigherriskpopulation.Weallowforthesimultaneouspresenceoftworisksandinvestigatethejointeffectoftwo-sourceuncertaintiesonhealthcareallocationwhenthetworisksareeithersmallorpositivelyquadrantdependent.Theeffectofinequalityaversiononhealthcareallocationisalsoanalyzedbyintroducinganequityweightingfunction.Ourworkextendsthepreviousmodelofhealthcareprioritytotwo-riskframeworkandprovidesnewinsightsintotheproblemofhealthcaredecisionmakingunderuncertainty.

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简介：Thepowderedactivatedcarbontreatment(PACT)processhasbeenwidelyusedinmanyindustrialfields,however,veryfewPACTprocessesarebuiltforpetrochemicalwastewatertreatmentinChina.AnindustrialPACTunitlaunchedinapetrochemicalplantwasintroducedandevaluatedfromboththepracticeandmechanismstudy.Practically,thePACTprocessshowedexcellentcapabilityinpollutantsremoval,shockresistance,toxicitytolerance,andtheCODandammonium-NineffluentofPACTunitassistedbyPACwasequalto15.5mg/Land0.7mg/LlowerthanthatwithoutPACaddition,respectively.ThewetoxidationregenerationunitwasquiteefficientinsupplyingregeneratedPAC,and,however,thehardcalciumsulphatescaleandthehighpollutantconcentrationsolutionneededtobecarefullycontrolled.Moreover,althoughthecarbonbalanceshowedthattheadsorptioncapabilityofregeneratedPACwasnegligible,thebiologicaltestsprovedthattheregeneratedPACincreasedmicrobeactivityupto17%morethanpureactivatedsludgesystem,whichwasalmostcompatiblewiththefreshactivatedcarbon.

简介：Ovariancanceristhesecondmostlethalgynecologicalcancerworldwideandwhilemostpatientsrespondtoinitialtherapy,theyoftenrelapsewithresistantdisease.Humanepidermalgrowthfactorreceptors(especiallyHER1/EGFRandHER2/ERBB2)areinvolvedindiseaseprogression;hence,strategiestoinhibittheiractioncouldproveadvantageousinovariancancerpatients,especiallyinpatientsresistanttofirstlinetherapy.Monoclonalantibodiesandtyrosinekinaseinhibitorsaretwoclassesofdrugsthatactonthesereceptors.Theyhavedemonstratedvaluableantitumoractivityinmultiplecancersandtheirpossibleuseinovariancancercontinuestobestudied.Inthisreview,wediscussthehumanepidermalgrowthfactorreceptorfamily;reviewemergingclinicalstudiesonmonoclonalantibodiesandtyrosinekinaseinhibitorstargetingthesereceptorsinovariancancerpatients;andproposefutureresearchpossibilitiesinthisarea.

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简介：Extragonadalprimaryyolksactumoroftheintestinaltractoriginisexceedinglyrare.Throughamultipledisciplinaryteam,thediagnosisandtreatmentofprimaryintestinalyolksactumorwerefurtherdefined.Wereport2suchcaseswithdetailedhistologicandimmunohistochemicalanalysis.Thetwopatientswerea7-year-oldgirlanda29-year-oldwoman.Bothofthempreoperativelyhadanelevatedserumalphafetoprotein(AFP)level(≥1,210ng/mL).Thetumorsarelocatedintheintestineandimagingexaminationindicatedtherectumastheprimarysite.Grosslythemasswasgrey-whiteandcrisptexture.Microscopicexaminationfeaturedreticular,microcystic,macrocystic,papillary,solid,andsomeglandularpatterns.Immunohistochemically,tumorcellsofbothcaseswerepositiveforSALL4,AFP,pan-cytokeratin(AE1/AE3),andglypican-3.Simultaneously,astainforEMA,OCT4,CD30,HCG,vimentinandCK20werenegativeinall2neoplasms.Thefeaturesofmorphology,immunohistochemistry,laboratoryexaminationsandimagingstudiesconsistofthediagnosisofprimaryyolksactumoroftheintestine.

简介：Inthispaper,aclustermodelinparticleflowcodewasusedtosimulategranitespecimensafterheattreatmentunderuniaxialcompression.Theresultsdemonstratedthatmicro-cracksarerandomlydistributedinthespecimenwhenthetemperatureisbelow300?C,andhavepartialcoalescencewhenthetemperatureisupto450?C,thenformmacro-crackswhenthetemperatureisabove600?C.Thereismoreinter-granularcrackingthanintra-granularcracking,andtheirratioincreaseswithincreasingtemperature.Themicro-cracksarealmostconstantwhenthetemperaturedecreasesfrom900?Ctoroomtemperature,exceptforquartzα–βphasetransitiontemperature(573?C).Thefractureevolutionprocessisobviouslyaffectedbythesecracks,especiallyat600–900?C.Elevatedtemperatureleadstoeasilydevelopeddisplacementbetweenthegrains,andthecapacitytostorestrainenergybecomesweaker,correspondingtotheplasticityofgraniteafterheattreatment.

简介：Nanocrystallinesurfacelayersandgradientnanostructurein5182aluminumalloyhavebeenproducedthroughsurfacemechanicalattritiontreatment(SMAT).Theresultsindicatethatthegradientnanostructurecannotonlyimprovethemechanicalpropertiesof5182Alalloy,butalsohasacertaineffectonthePortevin-LeChatelier(PLC)effect.Theyieldandultimatetensilestrengthof5182AlalloywithSMATaresignificantlyimprovedcombiningwiththedecreaseoffractureelongationcomparedwiththeas-receivedone.ThePLCeffectof5182AlalloycouldbeeffectivelypostponedbytheformationofgradientnanostructureafterSMAT,ItleadstotheincreaseofcriticalstrainofthePLCeffect,moreconcentrateddistributionofserratedstrain,andincreaseofaveragestressamplitudeinspecialstrainrange.TheinfluenceofgrainsizeandgradientnanostructureonthePLCeffectof5182Alalloywasalsodiscussedindetail,Grainrefinementcouldsharplyincreasethedensityofdislocationsandhinderthemovementofdislocations,whichresultsinthedecreaseofmovingspeedofdislocationsandthemoreconcentrateddistributionofsoluteatoms.Thesoluteatomswouldaggregatetoformnanoprecipitatesandfurtherimpedemovementofdislocation.ThestrongerinteractionbetweenthedislocationsandthenanoprecipitatesisthemainmechanismofpostponedPLCeffect.

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简介：基于Docetaxel的化疗在中国与变形阉割抵抗的前列腺癌症(mCRPC)为病人仍然是首要的治疗；然而，在这些病人与效果联系的预示的因素仍然是争论的。在这研究，我们回顾地从在我们的医院里从2009～2016收到了docetaxel化疗并且经历了前列腺特定的抗原(PSA)的减小的71个合格中国病人考察了数据在治疗期间的水平50%并且调查了PSA的天底(TTN)的时间的潜在的角色。TTN在治疗期间从化疗的开始被定义为时间到PSA水平的天底。穆尔蒂瓦拉布尔·考克斯回归模型和Kaplan-Meier分析被用来预言全面幸存(OS)。在这些病人，TTN中部是17个星期。有TTN17星期的病人与TTN相比有一更长的反应时间到化疗<17个星期(42.83对21.50个星期，P<0.001)。在有TTN17星期的病人的PSA前进的时间是与TTN是的5.63个星期相比的11.44个星期<17个星期。我们发现了几个因素与OS被联系，包括TTN(危险比率[HR]：3.937，95%信心间隔[CI]：1.502-10.309，P=0.005)，在癌症的诊断的PSA水平(HR：4.337，95%CI：1.616-11.645，P=0.004)，起始的雄激素剥夺治疗的持续时间(HR：2.982，95%CI：1.104-8.045，P=0.031)，neutrophil-to-lymphocyte比率(HR：3.963，95%CI：1.380-11.384，P=0.011)，并且全部的PSA反应(班1[<0反应]与班2相比[0-50%反应]，HR：3.978，95%CI：1.278-12.387，P=0.017)。在结论，PSA的TTN在在中国人口预言治疗学的结果仍然是一个重要预示的标记为mCRPC收到化疗并且有>50%PSA宽恕。