简介：在这篇论文，明智的NCP功能为非线性的不平等被建议的有片的一个QP免费的可行方法抑制了优化问题。新NCP功能arepiece明智的线性合理的、常规伪smooth并且有好性质。这个方法是KKToptimality条件的方程重新阐述的线性系统的基于的在解决方案，由使用thepiecewiseNCP函数。这个方法是没有假定严格的补充条件能、全球性会聚的工具，累积的孤立的海角指。而且，活跃限制的坡度没被请求线性地独立。可以被伪获得的次矩阵--牛顿方法，没被请求一致地积极明确。初步的数字结果显示这个新QP免费的方法是相当有希望的。

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简介：Inthispaper,necessaryandsufficientconditionsforaclosedrangecompositionoperatorC_φonthegeneralfamilyofholomorphicfunctionspacesF(p,q,s)andmoregenerallyonα-BesovtypespacesF(p,αp-2,s)aregiven.WegiveaCarlesonmeasurecharacterizationonF(p,αp-2,s)spaces,thenweindicatehowCarlesonmeasurescanbeusedtocharacterizeboundednessandcompactnessofC_φonF(p,q,s)andF(p,αp-2,s)spaces.

简介：Naturaladultagingisassociatedwithmanyfunctionalimpairmentsofthehumanneuromuscularsystem.Oneofthemoreobservablealterationsisthelossofcontractilemusclemass,termedsarcopenia.Thelossofmusclemassoccursprimarilyduetoaprogressivelossofviablemotorunits,andaccompanyingatrophyofremainingmusclefibers.Notonlydoesthelossofmusclemasscontributetoimpairedfunctioninoldage,butalterationsinfibertypeandmyosinheavychainisoformexpressionalsocontributetoweaker,slower,andlesspowerfulcontractingmuscles.Thisreviewwillfocusonmotorunitlossassociatedwithnaturaladultaging,age-relatedfatigability,andtheage-relateddifferencesinstrengthacrosscontractilemuscleactions.

简介：最近，产生在的许多重要非线性的部分微分方程使用了物理、数学的科学被一条流行途径处理了，所谓的终止功能方法。在这份报纸，我们由分析最近的结果的这个方法的现在的一些缺点出版了报纸。我们也讨论方法的有效性的可能的改进。

简介：采用恒星形成的观察分布在剩余的框架评估Lyman裂缝星系(LBG)的andhalf光半径紫外，我们以经验为主地为LBG调查预言的星的集体功能。一座山峰在1.5附近在质量存在，这被发现为他们的星的集体功能并且在那里的x10(10)M(圆点)是比10高的LBGswith星的群众(11)的重要数量在类似于3的z的M(圆点)。在那里，为LBG人口的二个家庭应该被红外线的数组照相机(IRAC)观察(它是在红外线的空间的一台关键仪器望远镜Spitzer)，一个人是红的，其它是蓝的，它与最近的工作一致。而且，为有不同星的群众的LBG的预言的comoving关联长度，即，与不同8亩m大小，也被讨论。红LBG应该比蓝LBG更强烈在空间被聚类。这些预言能被IRAC的观察测试，并且将在当前的层次星系形成模型上提供强壮的限制。

简介：ToobtaintherecombinantsolubleproteinoftheextracellularfragmentofhumanTRAILgeneandtoidentifyitsfunctionpreliminarily,thisgenefragmentwasamplifiedfromperipheralbloodmononu-clearcells(PBMC)byRT-PCRandclonedintovectorpGEM-T-Easyforsequenceanalysis.Theexpres-sionvectorpET-30a/TRAILwasthenconstructedbyDNArecombinationmethodwithaHis-taggeneatthefrontoftheTRAILfragment,andtherecombinantproteinwasexpressedinE.coliBL21(DE3).Meanwhile,theexpressedtargetproteinwaspurifiedwithNi-NTAchromatographycolumnandidentifiedbySDS-PAGEandWesternblotting.TheproliferationinhibitionactivityofTRAIL-HiswasdetectedbyMTTassay.PIstainingandWright-GiemsastainingwereusedtodetectthepresenceoftheTRAIL-in-ducedcellapoptosis.ItwasdemonstratedthatthetargetproteinexpressedinE.coliBL21showedthesamerelativemolecularmassasthattheproteinexpectedandcouldberecognizedbyboththeanti-TRAILpolyclonalantibodyandanti-Hismonoclonalantibody.Inaddition,thisproteincouldalsoinhibitprolif-erationofhumanlymphomacelllineJurkatcellsorinduceapoptosisofthiscellline.ItisapparentthatarecombinantsolubleTRAILproteinwithbiologicalactivityisobtainedandthisprospectivestudycanlaysolidfoundationforfurtherresearchonthebiologicalactivityandapplicationintheanti-tumortherapy.

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简介：StresscalculationformulaeforaringhavebeenobtainedbyusingAirystressfunctionoftheplanestrainfieldwiththedecompositionofthesolutionsfornormalstressesofAirybiharmonicequationintotwopartswhenitisloadedundertwooppositeinsideforcesalongadiameter.Onepartshouldfulfillaconstraintconditionaboutnormalstressdistributionalongthecircumferenceatanenergyvalleytodotheminimumwork.Otherpartisastressresidueconstant.Inordertoverifytheseformulaeandthecomputedresults,thecomputedcontourlinesofequi-maximalshearstresseswereplottedandquitecomparedwiththatofphoto-elasticitytestresults.ThisconstraintconditionaboutnormalstressdistributionalongcircumferenceisconfirmedbyusingGreens’theorem.Anadditionalcompressionexistsalongthecircumferenceoftheloadedring,explainingthedivorcementanddisplacementofsingularitypointsatinnerandouterboundaries.

简介：Incomparisonwiththenormalpeoplegroup,valuesofbloodCD2+andCD4+inpa-tientswithmallgnanttumorstreatedwithradiotherapyandchemotherapyweresignificantlylowerandtheratioofCD助+andCD8+decreasedobviously（allP<0.001）;CD8+hadnoapparentchange（P>0.05）.Followingacupuncturaltreatment,valuesofCD2+,CD4+andtheratioofCD4+toCD8+increasedobviously（allP<0.001）;whilethoseofthemedicinalcontrolgrouphadnosignificantchangeaftertreatment（P>0.05）.ValuesofIgG,IgAandIgMinpatients’serumpresentedanabnormalde-creasingorincreasingtendency,andC3inminorityofpatientswereraised.ResultsindicatedthattherewasabiphasicregulatoryeffectofacupunctureonthedisturbanceofhumoralimmunityandcouldcorrectthedeviationofC3level;anditseffectwasbetterthanorsimilartothatofthemedicinecontrolgroup.Itdemonstratesthatacupuncturecanenhanceandregulate.theimmunefunctionofpa-tientstreatedwithradiotherapya

简介：Inthispaper,thedefinitionsofBayesestimator,minimaxestimator,minimumriskequivariantestimatorandadmissibleestimatorunderthegeneralmatrixlossfunctionaregiven.Severalresultsonestimationofparameterswiththeordinarylossfunctionareextendedtothecaseofthematrixlossfunction.

简介：Hormonesandtheirreceptorsregulatecellgrowth,differentiationandapoptosisandalsoplayimportantrolesinimmunefunction.Recentstudiesonthesubfamilyoftheorphannuclearreceptorsknownasretinoid-acidrelatedorphanreceptors(ROR)haveshedimportantinsightsontherolesofthisgroupofnuclearproteinsinthedevelopmentandfunctionoftheimmunesystem.RORαregulatesinflammatorycytokineproductioninbothinnateandadaptiveimmunesystemwhileRORγregulatesthenormaldevelopmentofTlymphocyterepertoireandsecondarylymphoidorgans.Cellular&MolecularImmunology.2004;1(6):401-407.

简介：AbstractKeratinocytes, located in the outer part of human skin, are the main epidermal cell type and play an essential role in skins defense against infection. Besides creating a physical barrier between the environment and the internal body, keratinocytes exert powerful immune function in anti-pathogen infection in the skin. At the recognition stage, pattern recognition receptors (PRRs) expressed by keratinocytes sense pathogen-associated molecular patterns (PAMPs) existing in pathogens. Toll like receptors (TLRs) are the most important PRRs in keratinocytes. Other PRRs such as dectin-1 and nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) are also found to participate in this process. Activated PRRs enhance the secretion of cytokines, chemokines and the production of antimicrobial peptides (AMPs). Proinflammatory cytokines tumor necrosis factor-α, interleukin (IL)-1α, IL-6, IL-1β and IL-18, chemokines (C-X-Cmotif) ligand (CXCL) 1, CXCL2, CCL20, CCL2 and IL-8, AMPs human β-defensin (HBD) 2, HBD3 and LL37 are the main molecules expressed in this procedure. Thymic stromal lymphopoietin (TSLP), IL-36γ, IL-17 family member IL- 17C and anti-inflammatory cytokine IL-10 can also be secreted. Some molecules produced by keratinocytes such as ribonuclease 5 and 7, S100 proteins own antimicrobial properties. Keratinocytes defense responses can be regulated by internal and external factors. This review summarizes recent advances on the innate immune function of keratinocytes against infection, promoting the finding of a new direction for avoiding severe skin infection as well as the potential treatment of keratinocyte-associated inflammatory dermatosis.

简介：Theconceptofconvextypefunctionisintroducedinthispaper,fromwhichakindofconvex-decompositionapproachisproposed.Asoneofapplicationsofthisapproach,theapproximationoftheconvextypefunctionbythepartialsumofitsFourierseriesisinvestigated.Moreover,theorderofapproximationisdescribedwiththe2thcontinuousmodulus.

简介：Anewsmoothgapfunctionfortheboxconstrainedvariationalinequalityproblem(VIP)isproposedbasedonanintegralglobaloptimalitycondition.Thesmoothgapfunctionissimpleandhassomegooddifferentiableproperties.TheboxconstrainedVIPcanbereformulatedasadifferentiableoptimizationproblembytheproposedsmoothgapfunction.Theconditions,underwhichanystationarypointoftheoptimizationproblemisthesolutiontotheboxconstrainedVIP,arediscussed.Asimplefrictionalcontactproblemisanalyzedtoshowtheapplicationsofthesmoothgapfunction.Finally,thenumericalexperimentsconfirmthegoodtheoreticalpropertiesofthemethod.

简介：Anaccuratecracksurfaceopeningdisplacementformulaforedgecracksinfinitebodieshasbeenderived,andwassubsequentlyusedtodevelopwide-rangeclosed-formweightfunctionsforedgecracks.Theanalyticalweightfunctionisgeneralandcanbeeasilyusedtodetermineaccuratestressintensityfactorsandcracksurfaceopeningdisplacementsforarbitrarilyloadededgecrackswithhighefficiency.Exampleshavebeengivenforproblemsofedgecrack(s)withanumberoftypicalloadconditionsforillustration.

简介：钾(K)在植物影响生理的过程的一个范围并且是控制庄稼生产率和收益质量的一个关键因素。很少信息都不有关切割花植物的功能上的K营养的效果是可得到的。现在的学习被执行调查在K和N营养之间的相互作用，在花数量和毛莨属asiaticusL的质量上。植物与Kfertigation的三个层次被供应(60，120，或180mgKL−；1)不到50mgNL−；1应用，并且在120mgKL−的中间的水平；1，到N应用的三个层次(50，100，或150mgNL−；1)。二最低K治疗和最低N治疗由于更低的发生在花生产为佼佼者倒下茎，在很快扩展花茎的纸巾与局部性的Ca缺乏联系的混乱。有害效果在180mgKL−的供应下面已经以收益质量是明显的；1和50mgNL−；1，并且没在渗透的潜在的、相对的水内容或植物织物的膜稳定性与变化被联系，或与在除在高N申请下面的减少的Ca以外的叶子的矿物质内容的变化。我们的结果建议R的一个低营养的要求。asiaticusL。为K和N，在在K和N的高集中的申请下面的减少的花质量的织物水关系的参与的缺乏，和茎由Ca的减少的可获得性在N和K的高申请下面倒下到花的膨胀织物的正式就职起源。

简介：被动tracer的概率分布函数(PDF)，由“一个吝啬的坡度”强迫了，被学习。首先，我们采取二条理论途径，Lagrangian和有条件的闭合形式体系，到学习如此的外部地强迫的被动示踪物的PDF。然后，我们在一个范围上并且为测试吝啬坡度的模型是否能被用于学习在中间的纬度混合的同温层的tracer的同温层的风遨游的中等范围的天气预报(ECMWF)的欧洲中心为理想化的随机的流动执行数字模拟地区，在哪个，并且是否一弱并且杆病房带平均数的坡度被示踪物漏通过极、热带的混合障碍维持在中间的纬度的示踪物变化的PDF与理论预言一致。数字模拟证明当散开的驱散被吝啬坡度的强迫平衡时，在随机的PDF流动，在ECMWF风中的南部半球的PDF显示出时间不变的指数的尾巴，与理论预言一致。在北半球，PDF展出non-Gaussian尾巴。然而，PDF尾巴不与理论期望一致。强迫的示踪物的PDF尾巴的长期的行为与腐烂的tracer的相比。腐烂的示踪物的PDF尾巴是时间依赖者，这被发现，并且演变向恭维比指数。

简介：Recently,IattendedaconferenceorganisedbytheEuropeanFoodSafetyAuthorityinthebeautifulandprosperousItaliancityofParma.Theoveralltopicoftheconferencewasriskassessment,andtheprogramincludedasectiononaspectsofenvironmentalriskassessment.Invariousareas,includingtheevalutionoftheeffectsofpesticideapplications,invasiveorganismsorgeneticallymodifiedplants(Arpaiaetal.,2014)preparinganenvironmentalriskassessmentisanobviouslyrelevantexercise.